Abstract:
:Avian myelocytomatosis virus MC29 inoculated into the wing web of 1-day-old Brown Leghorn chickens causes a high incidence of tumors, predominantly endotheliomas that are apparently induced directly by the action of the viral myc gene. Mutants of MC29, in which portions of the v-myc gene have been deleted and which have reduced ability to transform macrophages in vitro, induce few tumors, among which lymphomas and osteopetrosis predominate. Analysis of lymphomas from birds infected with mutant MC29 suggested that they were a result of helper virus action rather than the mutant MC29.
journal_name
Virologyjournal_title
Virologyauthors
Enrietto PJ,Hayman MJ,Ramsay GM,Wyke JA,Payne LNdoi
10.1016/0042-6822(83)90300-8subject
Has Abstractpub_date
1983-01-15 00:00:00pages
164-72issue
1eissn
0042-6822issn
1096-0341journal_volume
124pub_type
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