Characterization of a MH2 mutant lacking the v-myc oncogene.

abstract：:CD8 T cells contribute to effective clearance of mouse adenovirus type 1 (MAV-1) and to virus-induced pulmonary inflammation. We characterized effects of a CD8 T cell effector, TNF, on MAV-1 pathogenesis. TNF inhibited MAV-1 replication in vitro. TNF deficiency or immunoneutralization had no effect on lung viral loads...

journal_title：Virology

authors： Pant K,Chandrasekaran A,Chang CJ,Vageesh A,Popkov AJ,Weinberg JB

更新日期：2020-08-01 00:00:00

abstract：:New sequences have been obtained by successive overlapping RT-PCR extensions from the pol region of a retroviral RNA (multiple sclerosis-associated retroviral element, MSRV) amplified in retrovirus-like particles from patients with multiple sclerosis. gag and pol sequences are related to type C oncoviruses, whereas th...

journal_title：Virology

authors： Komurian-Pradel F,Paranhos-Baccala G,Bedin F,Ounanian-Paraz A,Sodoyer M,Ott C,Rajoharison A,Garcia E,Mallet F,Mandrand B,Perron H

更新日期：1999-07-20 00:00:00

abstract：:Virus-host interactions essential for alphavirus pathogenesis are poorly understood. To address this shortcoming, we coupled retrovirus insertional mutagenesis and a cell survival selection strategy to generate clonal cell lines broadly resistant to Sindbis virus (SINV) and other alphaviruses. Resistant cells had sign...

journal_title：Virology

authors： Kolokoltsova OA,Domina AM,Kolokoltsov AA,Davey RA,Weaver SC,Watowich SJ

更新日期：2008-07-20 00:00:00

abstract：:Long-term non-progressive HIV infection, characterized by low but detectable viral load and stable CD4 counts in the absence of antiviral therapy, is observed in about 5% of HIV-infected patients. Here we identified four therapy naïve individuals who are strongly seropositive for HIV-1 but who lack evidence of detecta...

journal_title：Virology

authors： Kloosterboer N,Groeneveld PH,Jansen CA,van der Vorst TJ,Koning F,Winkel CN,Duits AJ,Miedema F,van Baarle D,van Rij RP,Brinkman K,Schuitemaker H

更新日期：2005-08-15 00:00:00

abstract：:We described a simple method to introduce site-specific mutations into region E3 of adenovirus (Ad). Mutations are made in cloned Ad2 EcoRI-D (map position 76-83), then ligated between Ad5 EcoRI-A (map position 0-76) and EcoRI-B (map position 83-100) to complete the viral genome. We have used this method to isolate a ...

journal_title：Virology

authors： Wold WS,Deutscher SL,Takemori N,Bhat BM,Magie SC

更新日期：1986-01-15 00:00:00

abstract：:The spike (S) and hemagglutinin/esterase (HE) of bovine coronavirus (BCV) are the two envelope proteins that recognize the same receptor-determinant of 9-O-acetylneuraminic acid on host cells. However, the precise and relative roles of the two proteins in BCV infectivity remain elusive. To unequivocally determine thei...

journal_title：Virology

authors： Popova R,Zhang X

更新日期：2002-03-01 00:00:00

abstract：:The ability of some Sendai virus stocks to strongly activate IFNbeta has long been known to be associated with defective-interfering (DI) genomes. We have compared SeV stocks containing various copyback and internal deletion DI genomes (and those containing only nondefective (ND) genomes) for their ability to activate...

journal_title：Virology

authors： Strahle L,Garcin D,Kolakofsky D

更新日期：2006-07-20 00:00:00

abstract：:The nucleotide sequence of the leader and the gene encoding the nucleocapsid protein (NP) of mumps virus Miyahara strain have been determined. The leader sequence is 55 nucleotides in length and the NP gene is 1845 nucleotides in length, exclusive of poly(A). The NP gene codes for a protein of 549 amino acids, with a ...

journal_title：Virology

authors： Tanabayashi K,Takeuchi K,Hishiyama M,Yamada A,Tsurudome M,Ito Y,Sugiura A

更新日期：1990-07-01 00:00:00

abstract：:The HIV-2 viral accessory protein Vpx is related to, but distinct from the Vpr protein of HIV-1. Vpx is packaged into virions and as a component of the viral preintegration complex (PIC) is required for efficient virus replication in non-dividing cells. We have previously reported that the minimal transferable region ...

journal_title：Virology

authors： Belshan M,Mahnke LA,Ratner L

更新日期：2006-03-01 00:00:00

abstract：:In order to investigate the genome organization of the porcine epidemic diarrhea virus (PEDV) further, cDNA clones covering the region between the nucleocapsid and the spike (S) protein genes were independently constructed and sequenced for the two virulent isolates Br1/87 and CV777. Of the three major ORFs identified...

journal_title：Virology

authors： Duarte M,Tobler K,Bridgen A,Rasschaert D,Ackermann M,Laude H

更新日期：1994-02-01 00:00:00

abstract：:The effect of measles virus (MV) infection on mRNA expression and protein synthesis of cytokines in human malignant glioma cell lines (D-54 and U-251) was investigated. Primary MV infections led in both cell lines to the induction of interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), interferon-beta (IFN-beta), and...

journal_title：Virology

authors： Schneider-Schaulies J,Schneider-Schaulies S,Ter Meulen V

更新日期：1993-07-01 00:00:00

abstract：:Poliovirus replicons were constructed which contain the internal ribosome entry site (IRES) of encephalomyocarditis virus (EMCV) substituted for the poliovirus IRES. To monitor gene expression and encapsidation, the gene encoding firefly luciferase was substituted for the P1 gene. Replicons can be encapsidated followi...

journal_title：Virology

authors： Johansen LK,Morrow CD

更新日期：2000-08-01 00:00:00

abstract：:Genotype VI-paramyxovirus (GVI-PMV1) is a major cause of epidemic Newcastle-like disease in Columbiformes. This genotype of avian paramyxovirus type 1 has diversified rapidly since its introduction into the US in 1982 resulting in two extant lineages, which have different population growth properties. Although some GV...

journal_title：Virology

authors： Chong YL,Kim O,Poss M

更新日期：2014-08-01 00:00:00

abstract：:Hepatitis C virus (HCV) causes chronic hepatitis, which often results in the development of liver cirrhosis and hepatocellular carcinoma (HCC) worldwide. In this study, we demonstrated that the non-structural protein NS3 of HCV enhances cyclooxygenase-2 (COX-2) gene promoter activity, COX-2 mRNA expression, COX-2 prot...

journal_title：Virology

authors： Lu L,Wei L,Peng G,Mu Y,Wu K,Kang L,Yan X,Zhu Y,Wu J

更新日期：2008-02-05 00:00:00

abstract：:The human papillomavirus type 8 (HPV8) is associated with skin cancer development. The goal of this study was to investigate the effects of HPV8 oncoproteins on cellular gene expression and the identification of key regulators. We performed affymetrix microarray analyses to identify differentially expressed genes and ...

journal_title：Virology

authors： Kirschberg M,Heuser S,Syed AS,Steger G,Majewski S,Hufbauer M,Akgül B

更新日期：2019-09-01 00:00:00

abstract：:Monoclonal antibodies (MAb) against an O1 Suisse isolate of FMDV were used to identify epitopes on the virus particle and to determine their relative function. Six major antigenic sites containing one or more epitopes were identified using competition ELISA. An epitope relationship is proposed consisting of a trypsin-...

journal_title：Virology

authors： McCullough KC,Crowther JR,Carpenter WC,Brocchi E,Capucci L,De Simone F,Xie Q,McCahon D

更新日期：1987-04-01 00:00:00

abstract：:We have used a yeast two-hybrid system to show that human papillomavirus E7 proteins can form oligomeric complexes in vivo. The carboxyl-terminal cysteine-rich metal-binding domain is critical for this activity although amino-terminal sequences also contribute to oligomerization. Our experiments also reveal that E7 po...

journal_title：Virology

authors： Clemens KE,Brent R,Gyuris J,Münger K

更新日期：1995-12-01 00:00:00

abstract：:A viroid has been purified from avocado leaves infected by sunblotch disease and designated the avocado sunblotch viroid. It is a covalently closed circular RNA molecule with a molecular weight lower than that of chrysanthemum stunt viroid and citrus exocortis viroid while hybridization analysis with 32P-labeled compl...

journal_title：Virology

authors： Palukaitis P,Hatta T,Alexander DM,Symons RH

更新日期：1979-11-01 00:00:00

abstract：:Five revertants of a linker-scanning mutation adjacent to the stem-loop V attenuation determinant (X472) in the 5' noncoding region of poliovirus RNA were independently isolated from neuroblastoma cells and contained RNAs with seven nucleotide changes in the pyrimidine-rich region. Generation of the identical rare sec...

journal_title：Virology

authors： Stewart SR,Semler BL

更新日期：1999-11-25 00:00:00

abstract：:Human gammaherpesvirus 8 (HHV-8) is the etiologic agent of Kaposi's sarcoma, multicentric Castleman's disease and primary effusion lymphoma. Like other herpesviruses, the HHV-8 may exhibit latent or lytic cycle, both regulated by viral and host factors. Regarding host factors, we analysed the association of polymorphi...

journal_title：Virology

authors： Gonçales JP,Silva Júnior JVJ,Lopes TRR,Tozetto-Mendoza TR,de Farias Guimarães D,de Morais VMS,Coêlho MRCD

更新日期：2019-09-01 00:00:00

abstract：:Infected cell protein (ICP) 27 is an essential herpes simplex virus type 1 (HSV-1) phosphoprotein required for optimal viral DNA and early or late gene synthesis. Three slow-migrating immunoreactive species were detected using multiple anti-ICP27 antibodies following HSV-1 infection of HEp-2 and Vero cells in the pres...

journal_title：Virology

authors： Sanfilippo CM,Lombardozzi RC,Chirimuuta FN,Blaho JA

更新日期：2004-07-01 00:00:00

abstract：:Woodchuck hepatitis core antigen (WHcAg) particles purified from the liver of chronically infected animals were used for monoclonal antibody production. Most of the putative clones demonstrated anti-WHc specificity. However, the supernatants from several putative clones bound X antigen sequences from woodchuck hepatit...

journal_title：Virology

authors： Feitelson MA,Clayton MM,Phimister B

更新日期：1990-07-01 00:00:00

abstract：:The hepatitis B virus (HBV) is formed by budding. A stretch of 22 amino acids (aa) (matrix domain, MD, R103 - S124) in the large envelope protein L is crucial for virion formation and probably establishes contact to the nucleocapsid. Here, we assess the impact of sequence variations at numerous individual aa positions...

journal_title：Virology

authors： Schittl B,Bruss V

更新日期：2014-06-01 00:00:00

abstract：:A cDNA clone containing all of the 26 S mRNA coding region of the RNA genome of Venezuelan equine encephalitis (VEE) virus, virulent strain Trinidad donkey (TRD), has been constructed and sequenced. The nucleotide and deduced amino acid sequences of the 26 S RNA of VEE virus conform to the general organization of the ...

journal_title：Virology

authors： Kinney RM,Johnson BJ,Brown VL,Trent DW

更新日期：1986-07-30 00:00:00

abstract：:Tetherin (ST2/CD317) is a cellular protein that restricts the release from cells of some enveloped viruses including HIV-1. To examine if influenza virus is affected by tetherin, MDCK cells constitutively expressing human tetherin and control MDCK cells were infected with influenza virus. No difference was observed in...

journal_title：Virology

authors： Watanabe R,Leser GP,Lamb RA

更新日期：2011-08-15 00:00:00

abstract：:HK97 is a temperate dsDNA bacteriophage of Escherichia coli that is structurally similar to phage lambda, with an icosahedral head of triangulation (7) number 7. Although the capsids of several large dsDNA phages have been studied extensively using a variety of biophysical approaches, no high-resolution structure is a...

journal_title：Virology

authors： Wikoff WR,Duda RL,Hendrix RW,Johnson JE

更新日期：1998-03-30 00:00:00

abstract：:The molecular mechanism(s) by which human immunodeficiency virus (HIV-1) injures a T-cell line was studied. A pathological role for viral env proteins, which are inserted into the plasma membrane, has been previously demonstrated for HIV as well as other retroviruses which are cytopathic. We therefore initiated studie...

journal_title：Virology

authors： Lynn WS,Tweedale A,Cloyd MW

更新日期：1988-03-01 00:00:00

abstract：:Expression of Kaposi's sarcoma herpesvirus vFLIP, a potent activator of NFkB signaling, promotes latency. Inhibition of NFkB signaling promotes lytic reactivation. We previously reported that lytic inducer, RTA, inhibits vFLIP induced NFkB signaling by inducing the degradation of vFLIP via the proteasome. Here we repo...

journal_title：Virology

authors： Chmura JC,Herold K,Ruffin A,Atuobi T,Fabiyi Y,Mitchell AE,Choi YB,Ehrlich ES

更新日期：2017-01-15 00:00:00

abstract：:Priming of the viral glycoprotein (GP) by the cellular proteases cathepsin B and L (CatB, CatL) is believed to be essential for cell entry of filoviruses. However, pseudotyping systems that predominantly produce non-filamentous particles have frequently been used to prove this concept. Here, we report that GP-mediated...

journal_title：Virology

authors： González-Hernández M,Müller A,Hoenen T,Hoffmann M,Pöhlmann S

更新日期：2019-06-01 00:00:00

abstract：:Torque Teno Virus (TTV) has been assigned to the floating genus Anellovirus. TTV ssDNA genomes have a size of 3.6 to 3.8 kb and display up to 30% nucleotide diversity. The pathogenic potential of TTV is under investigation. To address a putative link of pathogenicity with the observed sequence variations, the transcri...

journal_title：Virology

authors： Mueller B,Maerz A,Doberstein K,Finsterbusch T,Mankertz A

更新日期：2008-11-10 00:00:00