Genetic variation in rotavirus serotype 4 subtypes.

abstract：:Oral-gastric delivery of vaccines is a preferred route of immunization and is particularly relevant to the development of vaccine-vector systems. We have investigated the ability of a replication deficient (E1-deleted) adenovirus construct (RAd68), which efficiently expresses the measles virus nucleocapsid (N) protein...

journal_title：Virology

authors： Sharpe S,Fooks A,Lee J,Hayes K,Clegg C,Cranage M

更新日期：2002-02-15 00:00:00

abstract：:Most adenoviral vectors use in gene therapy protocols derive from species C. However, expression of the primary receptor (human Coxsackievirus and Adenovirus receptor, hCAR) for these AdV is variable on cancer cells. In vivo targeting of a therapeutic gene to specific cells has then become a major issue in gene therap...

journal_title：Virology

authors： Renaut L,Colin M,Leite JP,Benko M,D'Halluin JC

更新日期：2004-04-10 00:00:00

abstract：:An antiserum was raised against a synthetic peptide corresponding to the 18 C-terminal amino acids of a putative 16K protein encoded by the 3'-terminal open reading frame of tobacco rattle virus (TRV) RNA-1. This antiserum was used to demonstrate expression of the 16K cistron in vivo. TRV-infected tobacco protoplasts ...

journal_title：Virology

authors： Angenent GC,Verbeek HB,Bol JF

更新日期：1989-04-01 00:00:00

abstract：:A retroviral element (MSRV) defining a family of genetically inherited endogenous retroviruses (HERV-W) has recently been characterized in cell cultures from patients with multiple sclerosis (MS). To address the possible relationship with MS, direct detection of circulating virion RNA was proposed but revealed technic...

journal_title：Virology

authors： Perron H,Jouvin-Marche E,Michel M,Ounanian-Paraz A,Camelo S,Dumon A,Jolivet-Reynaud C,Marcel F,Souillet Y,Borel E,Gebuhrer L,Santoro L,Marcel S,Seigneurin JM,Marche PN,Lafon M

更新日期：2001-09-01 00:00:00

abstract：:Viruses of the family Luteoviridae are ssRNA plant viruses that have particles that exhibit icosahedral symmetry. To identify the residues that might be exposed on the surface of the Potato leafroll virus (PLRV; genus Polerovirus, family Luteoviridae) capsid, and therefore involved in biological interactions, we perfo...

journal_title：Virology

authors： Terradot L,Souchet M,Tran V,Giblot Ducray-Bourdin D

更新日期：2001-07-20 00:00:00

abstract：:Lysolecithin permeabilization of vaccinia virus-infected cells was employed to prepare extracts that support faithful transcription initiation in vitro on plasmids possessing early, intermediate, and late viral gene promoters. Conditions which optimize transcription from each promoter were defined. The in vitro system...

journal_title：Virology

authors： Condit RC,Lewis JI,Quinn M,Christen LM,Niles EG

更新日期：1996-04-01 00:00:00

abstract：:It was recently proposed that HIV RT mutations that decrease RNase H activity increase zidovudine (AZT) resistance by delaying the degradation of the RNA template, allowing more time for AZTMP excision from the 3' end of the viral DNA. This predicts that suboptimal concentrations of an RNase H Inhibitor (RNHI), which ...

journal_title：Virology

authors： Davis CA,Parniak MA,Hughes SH

更新日期：2011-10-25 00:00:00

abstract：:Geminiviruses are small, ssDNA-containing plant viruses. Bean golden mosaic virus (BGMV) and tomato golden mosaic virus (TGMV) have bipartite genomes, the components of which are designated A and B. Although they are closely related, BGMV and TGMV nevertheless exhibit distinct host-specific phenotypes, with BGMV being...

journal_title：Virology

authors： Gillette WK,Meade TJ,Jeffrey JL,Petty IT

更新日期：1998-11-25 00:00:00

abstract：:It has previously been shown that the genome of RF virus, a variant of the human papovavirus, BK, consists of two DNA species, one (R1a) with a deletion corresponding to the early and the other (R2) with a deletion corresponding to the late region of BKV (A. Pater, M.M. Pater, and G. di Mayorca (1980). J. Virol. 36, 4...

journal_title：Virology

authors： Pater A,Pater MM,Chang LS,Slawin K,Di Mayorca G

更新日期：1983-12-01 00:00:00

abstract：:During viral entry, enveloped viruses require the fusion of their lipid envelope with host cell membranes. For coronaviruses, this critical step is governed by the virally-encoded spike (S) protein, a class I viral fusion protein that has several unique features. Coronavirus entry is unusual in that it is often biphas...

journal_title：Virology

authors： Millet JK,Whittaker GR

更新日期：2018-04-01 00:00:00

abstract：:Foot-and-mouth disease virus (FMDV) shows a remarkable antigenic variability. Like other RNA viruses, this virus has a high rate of mutation. It has been proposed that selection exerted by the host's antibodies could play a major role in the rapid evolution of FMDV. The present work reports the selection of FMDV antib...

journal_title：Virology

authors： Carrillo EC,Rojas ER,Cavallaro L,Schiappacassi M,Campos R

更新日期：1989-08-01 00:00:00

abstract：:Chikungunya virus (CHIKV) is a mosquito-borne RNA virus that causes Chikungunya fever in humans. In this study, we generated two DNA-based CHIKV infectious clones derived from an Indian Ocean Lineage SL11131 strain and a prototype Ross strain. When the replication capabilities of the infectious CHIKV in various cell l...

journal_title：Virology

authors： Suzuki Y,Tanaka A,Maeda Y,Emi A,Fujioka Y,Sakaguchi S,Vasudevan SG,Kobayashi T,Lim CK,Takasaki T,Wu H,Nakano T

更新日期：2021-01-02 00:00:00

abstract：:The cowpea strain of Southern bean mosaic virus (SBMV-C), a T = 3 icosahedral RNA virus, was dissociated to yield a ribonucleoprotein complex (RNPC) composed of the viral RNA and coat protein subunits. To determine if the coat protein subunits were bound to a specific site on the viral RNA, the RNPC was treated with r...

journal_title：Virology

authors： Hacker DL

更新日期：1995-03-10 00:00:00

abstract：:We analyzed various mutants of tomato leaf curl virus-India to investigate the role of ORFs AV3, AV2, and coat protein (CP) in viral replication, movement, and symptom development. The results of these studies indicate that ORF AV3 does not encode a protein. Plants inoculated with infectious DNA which contained deleti...

journal_title：Virology

authors： Padidam M,Beachy RN,Fauquet CM

更新日期：1996-10-15 00:00:00

abstract：:Prior genetic analysis suggests that there may exist an interaction between the products of the vaccinia virus genes A18R, a putative negative transcription elongation factor, and G2R, a putative positive transcription elongation factor. In addition, affinity purification of polyhistidine-tagged G2R protein overexpres...

journal_title：Virology

authors： Black EP,Moussatche N,Condit RC

更新日期：1998-06-05 00:00:00

abstract：:Mammalian orthoreoviruses (reoviruses) are highly useful models for studies of double-stranded RNA virus replication and pathogenesis. We previously developed a strategy to recover prototype reovirus strain T3D from cloned cDNAs transfected into murine L929 fibroblast cells. Here, we report the development of a second...

journal_title：Virology

authors： Kobayashi T,Ooms LS,Ikizler M,Chappell JD,Dermody TS

更新日期：2010-03-15 00:00:00

abstract：:Mutations disrupting helicase domain motifs of the Tobacco mosaic virus 126/183-kDa proteins were investigated for their effect on replicase function and assembly. These mutations inhibited virus replication but did not affect 126-kDa induced N gene resistance or RNAi suppression. However, in vivo expressed 126-kDa mo...

journal_title：Virology

authors： Wang X,Kelman Z,Culver JN

更新日期：2010-07-05 00:00:00

abstract：:The HPIV2 V protein inhibits type I interferon (IFN) induction and signaling. To manipulate the V protein, whose coding sequence overlaps that of the polymerase-associated phosphoprotein (P), without altering the P protein, we generated an HPIV2 virus in which P and V are expressed from separate genes (rHPIV2-P+V). rH...

journal_title：Virology

authors： Schaap-Nutt A,D'Angelo C,Amaro-Carambot E,Nolan SM,Davis S,Wise SM,Higgins C,Bradley K,Kim O,Mayor R,Skiadopoulos MH,Collins PL,Murphy BR,Schmidt AC

更新日期：2010-10-10 00:00:00

abstract：:It has been shown that the genomes of episomally maintained DNA viruses are tethered to host cell chromosomes during cell division, facilitating maintenance in dividing cells. The papillomavirus E2 protein serves this mechanism of viral genome persistence by simultaneously associating with chromatin and the viral geno...

journal_title：Virology

authors： Feeney KM,Saade A,Okrasa K,Parish JL

更新日期：2011-05-25 00:00:00

abstract：:A dodecapeptide containing the sequence of the C terminus of the nonstructural polyprotein of Sindbis virus has been synthesized and used to immunize rabbits. The antisera obtained precipitated polypeptides from cells infected with the HR strains of Sindbis or with temperature-sensitive mutants ts11 or ts18. Four diff...

journal_title：Virology

authors： Lopez S,Bell JR,Strauss EG,Strauss JH

更新日期：1985-03-01 00:00:00

abstract：:While the C-terminal domain of HIV-1 Vpu is critical for CD4 degradation, the transmembrane domain (TM) mediates ion channel activity, enhances virus release and is essential for counteracting CD317/Bst-2/Tetherin. Here we analyzed whether the ion channel activity of Vpu is required to antagonize CD317-mediated restri...

journal_title：Virology

authors： Bolduan S,Votteler J,Lodermeyer V,Greiner T,Koppensteiner H,Schindler M,Thiel G,Schubert U

更新日期：2011-07-20 00:00:00

abstract：:Here we address the role of RIG-I and TLR3 in differential cytokine responses against Simian Virus 5 (SV5) and two distinct cytokine inducing SV5 mutants. IFN-beta and IL-6 secretion was induced by infection with P/V-CPI-, an SV5 mutant with P/V substitutions, and were reduced by either siRNA-mediated knockdown of RIG...

journal_title：Virology

authors： Manuse MJ,Parks GD

更新日期：2010-02-05 00:00:00

abstract：:The infectivity in vivo, replication competence in vitro, and expression of viral genes of several molecularly cloned duck hepatitis B virus (DHBV) genomes were investigated. In addition, replication competence, core protein expression, and secretion of viral proteins were investigated for a grey heron hepatitis B vir...

journal_title：Virology

authors： Wildner G,Fernholz D,Sprengel R,Schneider R,Will H

更新日期：1991-11-01 00:00:00

abstract：:The behavior of two genetically different molecular clones of visna virus KV1772-kv72/67 and LV1-1KS1 was compared in vivo and in vitro. On intracerebral inoculation, clone KV1772-kv72/67 induced a similar response in five sheep as has already been reported with neurovirulent derivates of visna virus. Virus was freque...

journal_title：Virology

authors： Torsteinsdóttir S,Agnarsdóttir G,Matthíasdóttir S,Rafnar B,Andrésdóttir V,Andrésson OS,Staskus K,Pétursson G,Pálsson PA,Georgsson G

更新日期：1997-03-17 00:00:00

abstract：:Feline panleukopenia virus (FPV) is a pathogen whose canine-adapted form (canine parvovirus (CPV)) emerged in 1978. These viruses infect by binding host transferrin receptor type-1 (TfR), but also hemagglutinate erythrocytes. We show that hemagglutination involves selective recognition of the non-human sialic acid N-g...

journal_title：Virology

authors： Löfling J,Lyi SM,Parrish CR,Varki A

更新日期：2013-05-25 00:00:00

abstract：:It has been demonstrated in a number of systems that CD8+ T cells (T CD8+) can be induced by peptides encoded in alternative reading frames (ARFs) that do not appear to code for bona fide proteins. The biological relevance of ARF peptides remains to be firmly established, however. With this as a goal, we systematicall...

journal_title：Virology

authors： Chen W,Bennink JR,Yewdell JW

更新日期：2003-01-05 00:00:00

abstract：:Simian-human immunodeficiency virus encoding both reverse transcriptase (RT) and envelope genes of HIV-1 (RT Env SHIV) is important for evaluating biomedical prevention modalities for HIV/AIDS. We describe virological characterization of a clade B RT Env SHIV following infection of macaques via multiple routes. In viv...

journal_title：Virology

authors： Pal R,Galmin L,Pereira LE,Li B,Zhang J,Li D,Francis J,McNicholl JM,Weiss DE,Smith JM

更新日期：2012-10-10 00:00:00

abstract：:The location of the cistron encoding the genome-linked protein (VPg) in the potyvirus tobacco vein mottling virus (TVMV) was investigated. Precipitation of 125I-labeled VPg with anti-tobacco etch virus 49K nuclear inclusion protein antiserum (which reacts with the NIa nuclear inclusion protein of TVMV) indicated that ...

journal_title：Virology

authors： Shahabuddin M,Shaw JG,Rhoads RE

更新日期：1988-04-01 00:00:00

abstract：:Human adenovirus (HAdV) is a cause of significant morbidity and mortality in immunocompromised patients, especially after stem cell transplantation (SCT). Viral clearance has been attributed to CD4(+) T-cell responses against the Hexon-protein, but the frequency of specific T(HELPER) cells is extremely low or not dete...

journal_title：Virology

authors： Serangeli C,Bicanic O,Scheible MH,Wernet D,Lang P,Rammensee HG,Stevanovic S,Handgretinger R,Feuchtinger T

更新日期：2010-02-20 00:00:00

abstract：:The 64K surface protein of budded Autographa californica nuclear polyhedrosis virus (AcMNPV BV) is known to play a role in the functional entry of AcMNPV BV into Spodoptera frugiperda IPLB-SF-21 cells by adsorptive endocytosis. AcV1, a neutralizing monoclonal antibody, reacts with the 64K protein and in doing so preve...

journal_title：Virology

authors： Volkman LE,Goldsmith PA

更新日期：1988-09-01 00:00:00