Abstract:
:A retroviral element (MSRV) defining a family of genetically inherited endogenous retroviruses (HERV-W) has recently been characterized in cell cultures from patients with multiple sclerosis (MS). To address the possible relationship with MS, direct detection of circulating virion RNA was proposed but revealed technically difficult to perform in standardized conditions, in the face of multiple endogenous HERV-W copies. A parallel approach has evaluated MSRV potential pathogenicity in relation to characteristic features of multiple sclerosis, in particular, T-lymphocyte-mediated immunopathology. We report here that MSRV particles induce T-lymphocyte response with a bias in the Vbeta16 chain usage in surface receptor, whatever the HLA DR of the donor. A recombinant MSRV envelope-but not core-protein reproduced similar nonconventional activation. Molecular analysis of Vbeta CDR3 showed that Vbeta16 expansions are polyclonal. Our results thus provide evidence that MSRV envelope protein can trigger an abnormal immune response with similar characteristics to that of superantigens.
journal_name
Virologyjournal_title
Virologyauthors
Perron H,Jouvin-Marche E,Michel M,Ounanian-Paraz A,Camelo S,Dumon A,Jolivet-Reynaud C,Marcel F,Souillet Y,Borel E,Gebuhrer L,Santoro L,Marcel S,Seigneurin JM,Marche PN,Lafon Mdoi
10.1006/viro.2001.1045subject
Has Abstractpub_date
2001-09-01 00:00:00pages
321-32issue
2eissn
0042-6822issn
1096-0341pii
S0042-6822(01)91045-1journal_volume
287pub_type
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