High-affinity Rep-binding is not required for the replication of a geminivirus DNA and its satellite.

abstract：:It is well established that +ssRNA viruses manipulate cellular lipid homoeostasis and distribution to facilitate efficient replication. Here, we show that the cellular lipid ceramide is redistributed to the West Nile virus strain Kunjin virus (WNVKUN) replication complex (RC) but not to the dengue virus serotype 2 str...

journal_title：Virology

authors： Aktepe TE,Pham H,Mackenzie JM

更新日期：2015-10-01 00:00:00

abstract：:In order to investigate the global and dynamic host microRNAs (miRNAs)/messenger RNAs (mRNAs) expression alteration during in vitro acute HCV infection, a comprehensive microarray analysis was performed using human hepatoma cells. Totally, 108 human miRNAs and 1247 mRNAs were identified whose expression levels changed...

journal_title：Virology

authors： Liu X,Wang T,Wakita T,Yang W

更新日期：2010-03-01 00:00:00

abstract：:A combination of linker scanning mutagenesis and deletional analyses has been used to determine the role of individual DNA-protein binding sites on expression from the hepatitis B virus (HBV) enhancer I-X promoter (map position (mp) 1042-1354, HBV adw2). Linker scanning mutation of the EF-C site caused a 67.5% drop in...

journal_title：Virology

authors： Gustin K,Shapiro M,Lee W,Burk RD

更新日期：1993-04-01 00:00:00

abstract：:The parvovirus-encoded nonstructural (NS) proteins have been implicated in the cytopathogenicity of these agents. Although protein NS-1 of minute virus of mice (MVM) has been shown to be toxic, little is known about the role of NS-2 in this process. In order to determine the contribution of NS-1 and NS-2 to cytotoxici...

journal_title：Virology

authors： Legrand C,Rommelaere J,Caillet-Fauquet P

更新日期：1993-07-01 00:00:00

abstract：:The enteric adenovirus type 40 strain Dugan (Ad40) cannot be passaged in HeLa cells, but will grow in 293 cells, which express Ad5 E1 functions. To determine the reason for this limited host range, KB cell lines expressing Ad2 E1A, E1B, or E1A + E1B (L. E. Babiss, C. S. H. Young, P. B. Fisher, and H. S. Ginsberg, 1983...

journal_title：Virology

authors： Mautner V,Mackay N,Steinthorsdottir V

更新日期：1989-08-01 00:00:00

abstract：:Tombusviruses are small, plus-sense, single-stranded RNA viruses of plants. RNA-dependent RNA polymerases (RdRp) of two tombusviruses, Tomato bushy stunt virus (TBSV) and Cucumber necrosis virus (CNV), have been partially purified from infected Nicotiana benthamiana plants. The obtained RdRp complexes are capable of d...

journal_title：Virology

authors： Nagy PD,Pogany J

更新日期：2000-10-25 00:00:00

abstract：:To gain new insights regarding the role of Ku, the DNA-PK DNA-binding component, during lentiviral DNA integration, we have investigated the HIV-1 replication in Ku80-depleted human cells. CEM4fx cells underexpressing the Ku80 factor were selected after transduction by a retroviral vector expressing the Ku80 full-leng...

journal_title：Virology

authors： Jeanson L,Subra F,Vaganay S,Hervy M,Marangoni E,Bourhis J,Mouscadet JF

更新日期：2002-08-15 00:00:00

abstract：:The monoclonal antibody 2D5 neutralized vaccinia virus by preventing penetration of the virus and reacting with VP23-29K. The conformation of the VP23-29K was maintained by a disulfide bond(s), and the 2D5mAb reacted stronger with the nonreduced 23-kDa form than with the reduced 29-kDa form. We selected several escape...

journal_title：Virology

authors： Ichihashi Y,Oie M

更新日期：1996-06-15 00:00:00

abstract：:Marek's disease (MD) infection has been controlled effectively by vaccination using nononcogenic and/or attenuated oncogenic Marek's disease virus (MDV) vaccines. Thus far, there is little knowledge on the role of cell-mediated immune (CMI) responses during MDV infection or vaccination. To elucidate the importance of ...

journal_title：Virology

authors： Omar AR,Schat KA

更新日期：1996-08-01 00:00:00

abstract：:The binding of monoclonal antibodies to antigenic site 3 on the hemagglutinin-neuraminidase (HN) glycoprotein of Newcastle disease virus neutralizes viral infectivity and prevents syncytium formation by a mechanism other than the prevention of viral attachment. The virus can escape neutralization by these antibodies b...

journal_title：Virology

authors： Deng R,Wang Z,Glickman RL,Iorio RM

更新日期：1994-10-01 00:00:00

abstract：:Coronaviruses have a marked tropism for epithelial cells. Entry and release of the porcine transmissible gastroenteritis virus (TGEV) is restricted to apical surfaces of polarized epithelial cells, as we have recently shown (J. W. A. Rossen, C. P. J. Bekker, W. F. Voorhout, G. J. A. M. Strous, A. van der Ende, and P. ...

journal_title：Virology

authors： Rossen JW,Voorhout WF,Horzinek MC,van der Ende A,Strous GJ,Rottier PJ

更新日期：1995-06-20 00:00:00

abstract：:The amino-terminal domain of influenza A virus matrix protein (residues 1-164) was crystallized at pH 7 into a new crystal form in space group P1. This packing of the protein implies that M1(1-164) was monomeric in solution when it crystallized. Otherwise, the structure of the M1 fragment in the pH 7 crystals was the ...

journal_title：Virology

authors： Arzt S,Baudin F,Barge A,Timmins P,Burmeister WP,Ruigrok RW

更新日期：2001-01-20 00:00:00

abstract：:Primary varicella-zoster virus (VZV) infection of humans may result in latent infection of sensory neurons in the peripheral nervous system. To examine the interaction of VZV with the sensory neuron we infected immunochemically defined human neurons with cell-associated VZV. Utilizing double-label immunofluorescence t...

journal_title：Virology

authors： Wigdahl B,Rong BL,Kinney-Thomas E

更新日期：1986-07-30 00:00:00

abstract：:HIV-1 transcytosis has been proposed as a potential mechanism allowing the virus to cross the epithelium during mucosal transmission. Epitopes of the HIV-1 envelope involved in this process have not been identified yet. Here, we assessed a large panel of HIV neutralizing antibodies recognizing well-characterized epito...

journal_title：Virology

authors： Chomont N,Hocini H,Gody JC,Bouhlal H,Becquart P,Krief-Bouillet C,Kazatchkine M,Bélec L

更新日期：2008-01-20 00:00:00

abstract：:Structure-guided approaches to HIV-1 vaccine design depend on knowledge of the presentation of neutralizing epitopes on gp120, such as the epitope for the broadly neutralizing mAb b12. Here, we characterized predicted three-dimensional structures of functionally diverse gp120 proteins in their b12-bound conformation, ...

journal_title：Virology

authors： Sterjovski J,Churchill MJ,Ellett A,Wesselingh SL,Ramsland PA,Gorry PR

更新日期：2012-10-25 00:00:00

abstract：:We have characterized capsids made by seven temperature-sensitive (ts) mutants of HSV-1 previously shown to be defective in viral DNA processing and packaging at the nonpermissive temperature (NPT). The empty capsids isolated from mutant-infected cells at the NPT were devoid of DNA, cosedimented in sucrose with wt B c...

journal_title：Virology

authors： Sherman G,Bachenheimer SL

更新日期：1988-04-01 00:00:00

abstract：:The influenza PA-X protein is translated from the PA open reading frame from frameshifting and suppresses cellular gene expression due to its ribonuclease activity. We further defined the functional roles of PA-X by comparing PA-X proteins from two related viruses - equine influenza (EIV) and canine influenza (CIV) H3...

journal_title：Virology

authors： Feng KH,Sun M,Iketani S,Holmes EC,Parrish CR

更新日期：2016-09-01 00:00:00

abstract：:In our in vitro model for HPV16-mediated transformation, HPV16-immortalized human keratinocytes (HKc/HPV16) give rise to differentiation resistant, premalignant cells (HKc/DR). HKc/DR, but not HKc/HPV16, are resistant to growth inhibition by transforming growth factor beta (TGF-β), due to a partial loss of TGF-β recep...

journal_title：Virology

authors： Kowli S,Velidandla R,Creek KE,Pirisi L

更新日期：2013-12-01 00:00:00

abstract：:We have applied the procedure of Agrobacterium-mediated inoculation to develop a simple, efficient, and reproducible assay for the infectivity of the leafhopper-transmitted geminivirus, beet curly top virus (BCTV). This assay system was used to show that a coat protein mutant of BCTV is not infectious, but could be co...

journal_title：Virology

authors： Briddon RW,Watts J,Markham PG,Stanley J

更新日期：1989-10-01 00:00:00

abstract：:A mutant strain of polyoma virus encoding a truncated middle T protein has been studied for its ability to replicate and induce tumors following inoculation into newborn mice. Virus replication in the acute period prior to expected onset of tumors as well as persistence of virus in older animals were followed. The mut...

journal_title：Virology

authors： Freund R,Sotnikov A,Bronson RT,Benjamin TL

更新日期：1992-12-01 00:00:00

abstract：:To determine if sequence variations observed in cosmopolitan HTLV-I interfered with viral recognition by neutralizing antibodies, we evaluated the neutralization potential of sera from persons infected by HTLV-I of this clade selected for amino acid changes in their eny glycoproteins. Each serum was used to neutralize...

journal_title：Virology

authors： Blanchard S,Astier-Gin T,Moynet D,Edouard E,Guillemain B

更新日期：1998-05-25 00:00:00

abstract：:Varicella Zoster virus (VZV) productively infects humans causing varicella upon primary infection and herpes zoster upon reactivation from latency in neurons. In vitro studies using cell-associated VZV infection have demonstrated productive VZV-infection, while a few recent studies of human neurons derived from stem c...

journal_title：Virology

authors： Sloutskin A,Kinchington PR,Goldstein RS

更新日期：2013-09-01 00:00:00

abstract：:Plant virus-encoded movement protein(s) (MP), and for many viruses the coat protein (CP), is required to mediate viral spread between plant cells via plasmodesmata (PD). Most probably, the genomic RNA of potexviruses moves through PD as assembled virions and/or as ribonucleoprotein complexes containing the CP and 25-k...

journal_title：Virology

authors： Atabekov JG,Rodionova NP,Karpova OV,Kozlovsky SV,Poljakov VY

更新日期：2000-06-05 00:00:00

abstract：:Human herpesvirus-8 (HHV-8) variants have been found heterogeneously distributed among human populations living in diverse geographic regions, but their differential pathogenicity in Kaposi's sarcoma development remains controversial. In the present study, HHV-8 variant distribution has been analyzed in classic, iatro...

journal_title：Virology

authors： Tornesello ML,Biryahwaho B,Downing R,Hatzakis A,Alessi E,Cusini M,Ruocco V,Katongole-Mbidde E,Loquercio G,Buonaguro L,Buonaguro FM

更新日期：2010-03-15 00:00:00

abstract：:Hepatitis B virus (HBV) clone 4B replicated much more efficiently than clone 2A of the same genotype. Introduction of its T1753C, A1762T, G1764A, and C1766T core promoter mutations into the 2A genome greatly enhanced genome replication and suppressed HBeAg expression. Here we show that these effects are mediated by tr...

journal_title：Virology

authors： Tsai A,Kawai S,Kwei K,Gewaily D,Hutter A,Tong DR,Li J,Wands JR,Tong S

更新日期：2009-05-10 00:00:00

abstract：:The phosphorylation and transcriptional competence of the free cytoplasmic form and the virion form of NS protein of vesicular stomatitis virus (VSV-Indiana/Mudd-Summers) were compared. NS protein is known to exist in two distinct phosphorylated states, NS1 and NS2, that are resolvable by gel electrophoresis. In vitro...

journal_title：Virology

authors： Masters PS,Banerjee AK

更新日期：1986-10-30 00:00:00

abstract：:Particles purified from the liver of hepatitis B virus-infected patients were previously shown by us to incorporate 32P-deoxynucleotides into viral DNA and DNA-RNA hybrid molecules when incubated in a DNA polymerase reaction mixture. In this investigation, similar particles from duck and ground squirrel livers infecte...

journal_title：Virology

authors： Miller RH,Marion PL,Robinson WS

更新日期：1984-11-01 00:00:00

abstract：:Previous research has indicated that the adenovirus protein complex named RID, derived from the E3 transcription unit, functions to remove the receptors named Fas/Apo1/CD95 (Fas) and epidermal growth factor receptor (EGFR) from the surface of cells. (The RID complex is composed of the RIDalpha and RIDbeta polypeptides...

journal_title：Virology

authors： Toth K,Kuppuswamy M,Doronin K,Doronina O,Lichtenstein D,Tollefson A,Wold W

更新日期：2002-09-15 00:00:00

abstract：:Measles virus transcription generates multiple P/C gene-specific mRNAs by a process which has been termed editing. In one of these mRNAs, the cotranscriptional addition of a single nontemplated G residue allows translational access to the V protein reading frame. The protein translated from this mRNA has been called V...

journal_title：Virology

authors： Liston P,Briedis DJ

更新日期：1994-01-01 00:00:00

abstract：:A novel virus isolated from the feather follicles of cockatoos diagnosed as having psittacine beak and feather disease was characterized by electron microscopy, nucleic acid content, and polypeptide composition. Purified virions displayed an icosahedral symmetry, were nonenveloped, and had a mean diameter of 14 to 16 ...

journal_title：Virology

authors： Ritchie BW,Niagro FD,Lukert PD,Steffens WL 3rd,Latimer KS

更新日期：1989-07-01 00:00:00