Abstract:
:A mutant strain of polyoma virus encoding a truncated middle T protein has been studied for its ability to replicate and induce tumors following inoculation into newborn mice. Virus replication in the acute period prior to expected onset of tumors as well as persistence of virus in older animals were followed. The mutant virus proved to be defective in replication and persistence and failed to induce tumors. These results demonstrated that middle T plays an essential role in productive viral infection in the animal. Since the mutant virus encodes normal large and small T proteins, the results also indicate that functions associated with these T antigens, including large T binding of the retinoblastoma tumor suppressor gene product and the ability to immortalize, are insufficient to cause development of tumors in this system.
journal_name
Virologyjournal_title
Virologyauthors
Freund R,Sotnikov A,Bronson RT,Benjamin TLdoi
10.1016/0042-6822(92)90247-msubject
Has Abstractpub_date
1992-12-01 00:00:00pages
716-23issue
2eissn
0042-6822issn
1096-0341journal_volume
191pub_type
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