Abstract:
:The effects of P2 prophage on lambda-mediated depression of host metabolism, and on lambda macromolecular synthesis have been studied. Experiments employing certain lambdabio deletion mutants and lambda-related phages suggest that the same gene products are involved in inhibition of host metabolism (Hin+ function) and susceptibility to P2 inhibition (Spi+ function). Synthesis of early lambda mRNA and protein occurs normally during the first 10 min after lambda infection of P2 lysogens, but subsequent expression of early and late lambda genes is interfered with by the combined actions of the P2 old gene and lambda Hin+ (Spi+) function. In addition, the P2 old+ product enhances the inhibitory effects of lambda Hin+ function on host metabolism, and can substitute for a component of this function lacking in lambdabio 72 and lambdabio 69.
journal_name
Virologyjournal_title
Virologyauthors
Cohen SN,Chang ACsubject
Has Abstractpub_date
1971-11-01 00:00:00pages
397-406issue
2eissn
0042-6822issn
1096-0341pii
0042-6822(71)90041-9journal_volume
46pub_type
杂志文章相关文献
VIROLOGY文献大全abstract::The propensity of retroviruses to rapidly establish persistent infections poses a formidable problem in vaccination strategies. In the current study, we use a live attenuated vaccine to study protection against acute and persistent Friend virus infections in mice. Adoptive transfers of immune CD8(+) T cells combined w...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2000.0356
更新日期:2000-06-20 00:00:00
abstract::Infectious bronchitis has remained one of the most difficult to control diseases in poultry since it was first described in 1931. Previous studies demonstrated that primary CD8(+) T lymphocytes collected at 10 days post-infection (p.i.) are important in controlling acute infection. To further investigate the role of m...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/s0042-6822(02)00059-4
更新日期:2003-02-15 00:00:00
abstract::We previously described a thymus-tropic HIV-1 envelope (R3A Env) from a rapid progressor obtained at the time of transmission. An HIV-1 molecular recombinant with the R3A Env supported extensive replication and pathogenesis in the thymus and did not require Nef. Another Env from the same patient did not display the sa...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2005.03.032
更新日期:2005-06-05 00:00:00
abstract::Human papillomavirus (HPV) is a family of viruses divided into five genera: alpha, beta, gamma, mu, and nu. There is an ongoing discussion about whether beta genus HPVs (β-HPVs) contribute to cutaneous squamous cell carcinoma (cSCC). The data presented here add to this conversation by determining how a β-HPV E6 protei...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2020.07.016
更新日期:2020-10-01 00:00:00
abstract::We have studied the assembly of human immunodeficiency virus (HIV-1) Gag-B-galactosidase (Gag-B-gal; GBG) fusion proteins into HIV particles in the presence of HIV Gag proteins. Release of fusion proteins from cells was measured by assay of media versus cellular B-gal activities and was dependent on co-expression of u...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1994.1215
更新日期:1994-05-01 00:00:00
abstract::The caprine arthritis-encephalitis (CAEV) and ovine maedi-visna (MVV) viruses are resistant to antibody neutralization, a feature shared with all other lentiviruses. Whether the CAEV gp135 receptor binding site(s) (RBS) in the functional surface envelope glycoprotein (Env) is protected from antibody binding, allowing ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2005.05.028
更新日期:2005-09-01 00:00:00
abstract::The relationship between the cell cycle and the presence of the nuclear T antigen in simian virus 40-transformed rat cells independently derived from FR 3T3 cells has been investigated using a fluorescence-activated cell sorter and a combination of stainings for cellular DNA (4',6-diamidine-2-phenylindole dihydrochlor...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/s0042-6822(83)80028-2
更新日期:1983-04-30 00:00:00
abstract::A dodecapeptide containing the sequence of the C terminus of the nonstructural polyprotein of Sindbis virus has been synthesized and used to immunize rabbits. The antisera obtained precipitated polypeptides from cells infected with the HR strains of Sindbis or with temperature-sensitive mutants ts11 or ts18. Four diff...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(85)90254-5
更新日期:1985-03-01 00:00:00
abstract::Three SV40 escape mutants were identified by selection in the presence of monoclonal antibodies with neutralizing activity. The VP1 amino acid alterations in these mutants were: (1) K73-->E (in loop BC); (2) D77-->E (in loop BC); (3) K171-->R (in loop EF); and (4) Q175-->H (in loop EF). These residues are clustered in...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2008.07.032
更新日期:2008-11-10 00:00:00
abstract::The sequence of the 5'-end of the genome of dengue 2 (Jamaica genotype) virus has been previously reported (V. Deubel, R. M. Kinney, and D. W. Trent, 1986, Virology 155, 365-377). We have now cloned and sequenced the remaining 75% of the genomic RNA that encodes the nonstructural proteins. The complete genome is 10,72...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(88)90677-0
更新日期:1988-07-01 00:00:00
abstract::Human rotaviruses (Wa, KUN, MO) showed hemagglutination (HA) only with fixed 1-day-old chicken erythrocytes, and their HA activities were completely destroyed by trypsin activation of virions. Simian SA-11 and bovine NCDV had HA activities not only against fixed erythrocytes but also against fresh erythrocytes from va...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(89)90121-9
更新日期:1989-09-01 00:00:00
abstract::Avian influenza A viruses of the H5 and H7 subtypes periodically cause severe outbreaks of disease in poultry. The question we wished to address in this study is whether these highly pathogenic strains constitute unique lineages or whether they and related nonpathogenic viruses are derived from common ancestors in the...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1995.1301
更新日期:1995-06-01 00:00:00
abstract::We have cloned an infectious genome of the Junonia coenia densonucleosis virus (JcDNV) into the bacterial plasmid pBR322. The viral genome could be rescued from the recombinant plasmid pBRJ by transfection of pBRJ DNA to sensitive Spodoptera littoralis larvae. pBRJ DNA produced a typical viral infection and a comparab...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(90)90308-e
更新日期:1990-11-01 00:00:00
abstract::HPV16 E6 deregulates G1/S cell cycle progression through p53 degradation preventing transcription of the CDK inhibitor p21(WAF1). However, additional mechanisms independent of p53 inactivation appear to exist. Here, we report that HPV16 E6 targets the cellular factor p150(Sal2), which positively regulates p21(WAF1) tr...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.05.016
更新日期:2011-09-01 00:00:00
abstract::HIV-1 transmission is usually initiated by a single viral strain called transmitted/ founder (T/F) virus. In in vitro models, HIV-1 can efficiently spread via cell-free and virological synapse (VS)-mediated cell-to-cell infection. Both modes of infection require the viral glycoprotein Envelope (Env). The efficiency wi...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.10.016
更新日期:2019-01-02 00:00:00
abstract::Tombusviruses, of which tomato bushy stunt virus (TBSV) is the type member, spontaneously generate defective interfering RNAs (DIs) that are known to interfere with viral accumulation and symptom development. We show that co-infection with TBSV and DIs causes a dramatic reduction in accumulation of TBSV subgenomic RNA...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1995.1410
更新日期:1995-08-01 00:00:00
abstract::Expression of the SV40 large T-antigen allows primary cells to escape senescence and thereby become immortalized. Immortalization occurs in two steps, extension of life span and acquisition of unlimited cell division potential. By following the increase in expression of a senescence-associated marker with increased ce...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1998.9056
更新日期:1998-04-10 00:00:00
abstract::Synthesis of unintegrated retroviral DNA via reverse transcription is thought to involve two separate template switches. Minus-strand strong-stop DNA, a major product of in vitro reactions using detergent-treated virions, is synthesized prior to the first template switch. Plus-strand strong-stop DNA, which is found ba...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1993.1237
更新日期:1993-05-01 00:00:00
abstract::Sequence variants of the Epstein-Barr virus (EBV)-encoded latent membrane protein-1 (LMP1) have been reported in association with EBV-linked malignancies but little is known about their effects on signalling pathways and phenotype. We have examined the ability of the nasopharyngeal carcinoma (NPC)-derived variant, CAO...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2001.0828
更新日期:2001-04-10 00:00:00
abstract::Many antiviral drugs must be metabolized to their active form by cellular enzymes. Their antiviral activity may therefore be limited by an inefficient metabolism, leading to low intracellular concentration of the active form or to the accumulation of toxic intermediate metabolites. Gene transfer might be used to overc...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1997.8706
更新日期:1997-09-01 00:00:00
abstract::Coronavirus small envelope protein E has two known biological functions: it plays a pivotal role in virus envelope formation, and the murine coronavirus E protein induces apoptosis in E protein-expressing cultured cells. The E protein is an integral membrane protein. Its C-terminal region extends cytoplasmically in th...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2001.0818
更新日期:2001-03-15 00:00:00
abstract::Currently, little is known about the ankyrin/F-box protein B4. Here, we report that B4R-null viruses exhibited reduced plaque size in tissue culture, and decreased ability to spread, as assessed by multiple-step growth analysis. Electron microscopy indicated that B4R-null viruses still formed mature and extracellular ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.03.019
更新日期:2014-05-01 00:00:00
abstract::The phosphorylated protein pp65 of human Cytomegalovirus (HCMV) is the predominant virion protein and the major tegument constituent. It plays important roles in HCMV infection and virion assembly. Live cell imaging and fluorescence recovery after photobleaching (FRAP) analysis showed that HCMV pp65 accumulated dynami...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2009.06.021
更新日期:2009-09-30 00:00:00
abstract::Cucumber Mosaic Virus (CMV) is a plant infecting tripartite positive-strand RNA virus. In addition to three genomic and two known subgenomic RNAs, CMV strains of subgroup II (e.g. Q-CMV), but not subgroup I (e.g. Fny-CMV), produce and package a redundant RNA5 encompassing the 3' 304-307 nucleotides of RNAs 2 and 3. Th...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2008.10.023
更新日期:2009-02-05 00:00:00
abstract::Seven structural component proteins of a paramyxovirus simian virus 41 (SV41) were identified with the aid of monoclonal antibodies prepared against SV41 and human parainfluenza type 2 virus (PIV2). The nucleoprotein is antigenically very close to that of PIV2, while it is comparatively far from that of simian virus 5...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(90)90141-d
更新日期:1990-12-01 00:00:00
abstract::The protein p10 that forms the connector of phage phi 29, has been produced in Escherichia coli harboring a plasmid that carried the gene coding for this protein. The connector protein is assembled in a 13.4-S oligomer that has an apparent molecular weight of 460,000, suggesting that it is a dodecamer. The purified ol...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(85)90251-x
更新日期:1985-03-01 00:00:00
abstract::The E7 transforming protein of Human Papillomavirus type 16 (HPV16) is expressed in the skin of a line of FVB mice transgenic for the E6 and E7 open reading frames of HPV16 driven from the alpha A crystallin promoter (FVB alpha AcryHPV16E6E7). We have transferred skin from FVB alpha AcryHPV16E6E7 mice to naive or E7-p...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1997.8650
更新日期:1997-08-18 00:00:00
abstract::It has been widely demonstrated that the human immunodeficiency virus type 1 (HIV-1) envelope, specifically the V3 loop of the gp120 spike, evolves to facilitate adaptation to different cellular populations within an infected host. Less energy has been directed at determining whether the viral promoter, designated the...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2000.0476
更新日期:2000-09-01 00:00:00
abstract::The complete DNA sequence of a new lytic T7-like bacteriophage phiKMV is presented. It is the first genome sequence of a member of the Podoviridae that infects Pseudomonas aeruginosa. The linear G + C-rich (62.3%) double-stranded DNA genome of 42,519 bp has direct terminal repeats of 414 bp and contains 48 open readin...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/s0042-6822(03)00123-5
更新日期:2003-07-20 00:00:00
abstract::Antigenic variation among influenza B viruses is different from that of influenza A in several ways. Antigenic shift has not been observed, distinct antigenic variants of influenza B cocirculate, and antigenically similar viruses have been isolated many years apart. To study the mechanism of antigenic drift in influen...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(84)90384-2
更新日期:1984-12-01 00:00:00