Abstract:
:Although rodents are important reservoirs for RNA viruses, to date only one species of rodent coronavirus (CoV) has been identified. Herein, we describe a new CoV, denoted Lucheng Rn rat coronavirus (LRNV), and novel variants of two Betacoronavirus species termed Longquan Aa mouse coronavirus (LAMV) and Longquan Rl rat coronavirus (LRLV), that were identified in a survey of 1465 rodents sampled in China during 2011-2013. Phylogenetic analysis revealed that LAMV and LRLV fell into lineage A of the genus Betacoronavirus, which included CoVs discovered in humans and domestic and wild animals. In contrast, LRNV harbored by Rattus norvegicus formed a distinct lineage within the genus Alphacoronavirus in the 3CL(pro), RdRp, and Hel gene trees, but formed a more divergent lineage in the N and S gene trees, indicative of a recombinant origin. Additional recombination events were identified in LRLV. Together, these data suggest that rodents may carry additional unrecognized CoVs.
journal_name
Virologyjournal_title
Virologyauthors
Wang W,Lin XD,Guo WP,Zhou RH,Wang MR,Wang CQ,Ge S,Mei SH,Li MH,Shi M,Holmes EC,Zhang YZdoi
10.1016/j.virol.2014.10.017subject
Has Abstractpub_date
2015-01-01 00:00:00pages
19-27eissn
0042-6822issn
1096-0341pii
S0042-6822(14)00472-3journal_volume
474pub_type
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