当前位置： SCI文献检索 > VIROLOGY期刊下所有文献 > Changing sensitivity to broadly neutralizing antibodies b12, 2G12, 2F5, and 4E10 of primary subtype B human immunodeficiency virus type 1 variants in the natural course of infection.

Changing sensitivity to broadly neutralizing antibodies b12, 2G12, 2F5, and 4E10 of primary subtype B human immunodeficiency virus type 1 variants in the natural course of infection.

Abstract：

:The conserved nature of the epitopes of the four broadly neutralizing antibodies (BNAbs), b12, 2G12, 2F5, and 4E10, may imply that the sensitivity of HIV-1 for these BNAbs remains fairly constant over the course of infection. Here, we demonstrate that viruses isolated early during the course of infection were mostly sensitive to HIVIg and antibody neutralization, although variation was observed in neutralization sensitivity of coexisting viruses to the different antibodies as well as between viruses from different patients. HIV-1 resistance to HIVIg developed relatively early during follow-up in three out of five patients, while early, b12 sensitive viruses in three out of five patients were replaced by b12 resistant variants relatively late in infection. In contrast, viruses generally remained sensitive to 2F5 and 4E10 neutralization over the course of infection, although 2F5 and/or 4E10 resistant variants did emerge later in infection in four out of five patients. In most patients, HIV-1 resistance to 2F5 or 4E10 did not correlate with mutations at critical amino acid positions in their defined epitopes. Viruses resistant to 2G12-mediated neutralization were present throughout the course of infection. As viral resistance against BNAb-mediated neutralization generally developed when autologous serum neutralizing activity had faded, it seems unlikely that these changes are driven by escape from autologous humoral immunity.

journal_name

Virology

journal_title

Virology

authors

Bunnik EM,van Gils MJ,Lobbrecht MS,Pisas L,van Nuenen AC,Schuitemaker H

doi

10.1016/j.virol.2009.05.028

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

348-55

issue

2

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(09)00335-3

journal_volume

390

pub_type

杂志文章

相关文献

VIROLOGY文献大全
  • Comparing the functions of equine and canine influenza H3N8 virus PA-X proteins: Suppression of reporter gene expression and modulation of global host gene expression.

    abstract：:The influenza PA-X protein is translated from the PA open reading frame from frameshifting and suppresses cellular gene expression due to its ribonuclease activity. We further defined the functional roles of PA-X by comparing PA-X proteins from two related viruses - equine influenza (EIV) and canine influenza (CIV) H3...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2016.06.001

    authors： Feng KH,Sun M,Iketani S,Holmes EC,Parrish CR

    更新日期：2016-09-01 00:00:00

  • Maize chlorotic mottle machlomovirus and wheat streak mosaic rymovirus concentrations increase in the synergistic disease corn lethal necrosis.

    abstract：:Corn lethal necrosis (CLN) is caused by the synergistic interaction between maize chlorotic mottle machlomovirus (MCMV) and any potyvirus which infects cereals. Interactions between MCMV and wheat streak mosaic rymovirus (WSMV) in N28Ht corn produced MCMV concentrations that averaged 3.3- to 11.2-fold higher in doubly...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1997.8989

    authors： Scheets K

    更新日期：1998-03-01 00:00:00

  • The herpes simplex virus immediate-early protein ICP27 shuttles between nucleus and cytoplasm.

    abstract：:ICP27 is an essential herpes simplex virus type 1 (HSV-1) nuclear protein which regulates viral early and late genes during infection. The exact mechanism by which ICP27 modulates viral gene expression is unknown, but considerable evidence suggests that it functions posttranscriptionally. In this study, we have asked ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1997.9006

    authors： Mears WE,Rice SA

    更新日期：1998-03-01 00:00:00

  • Assembly of viroplasm and virus-like particles of rotavirus by a Semliki Forest virus replicon.

    abstract：:In this study we have used an expression system based on Semliki Forest virus (SFV) to study assembly and intracellular localization of certain capsid proteins of rotavirus in neurons and mammalian epithelial cells. The complete genes of vp2 (vp2A) and vp6 (vp6A) of group A rotavirus (SA-11) and gene 5 encoding vp6 (v...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1997.8987

    authors： Nilsson M,von Bonsdorff CH,Weclewicz K,Cohen J,Svensson L

    更新日期：1998-03-15 00:00:00

  • Evidence for a continued requirement for CD40/CD40 ligand (CD154) interactions in the progression of LP-BM5 retrovirus-induced murine AIDS.

    abstract：:In genetically susceptible C57BL/6 mice the LP-BM5 isolate of murine retroviruses causes profound splenomegaly, lymphadenopathy, hypergammaglobulinemia, and an immunodeficiency syndrome bearing many similarities to the pathologies seen in AIDS. Because of these similarities, which also include terminal B cell lymphoma...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1997.8970

    authors： Green KA,Noelle RJ,Green WR

    更新日期：1998-02-15 00:00:00

  • Phenotypic and functional characterization of CD8(+) T cell clones specific for a mouse cytomegalovirus epitope.

    abstract：:A series of CD8(+) T cell clones, specific for the IE1 epitope YPHFMPTNL, of the immediate-early protein 1 of the murine cytomegalovirus (MCMV) were generated in order to determine their protective activity against this infection and correlate their phenotypic markers with antiviral activity. We found that the adoptiv...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1998.9575

    authors： Fernandez JA,Zavala F,Tsuji M

    更新日期：1999-03-01 00:00:00

  • Umbravirus-encoded proteins both stabilize heterologous viral RNA and mediate its systemic movement in some plant species.

    abstract：:The proteins encoded by open reading frame 3 (ORF3) of the umbraviruses pea enation mosaic virus-2 and tobacco mottle virus, like that of groundnut rosette virus, mediated the movement of viral RNA through the phloem of infected Nicotiana benthamiana or N. clevelandii plants when they were expressed from chimeric toba...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2001.1078

    authors： Ryabov EV,Robinson DJ,Taliansky M

    更新日期：2001-09-30 00:00:00

  • A physical map of caprine arthritis-encephalitis provirus.

    abstract：:Terminally redundant linear proviral DNA of approximately 9.5 kb was the major unintegrated species recovered in the Hirt supernatant fraction of caprine synovial membrane cells infected with strain 75-G63 caprine arthritis-encephalitis virus. A physical map based on the cleavage sites of 13 restriction endonucleases ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(84)90318-0

    authors： Roberson SM,Cheevers WP

    更新日期：1984-04-30 00:00:00

  • Natural variants of human adenovirus type 3 provide evidence for relative genome stability across time and geographic space.

    abstract：:Human adenovirus type 3 (HAdV-B3) has an apparently stable genome yet remains a major circulating and problematic respiratory pathogen. Comparisons of the prototype genome to genomes from three current field strains, including two isolated from epidemics, and a laboratory strain, yielded small-scale nucleotide variati...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2009.10.052

    authors： Mahadevan P,Seto J,Tibbetts C,Seto D

    更新日期：2010-02-05 00:00:00

  • Endoplasmic reticulum export and vesicle formation of the movement protein of Chinese wheat mosaic virus are regulated by two transmembrane domains and depend on the secretory pathway.

    abstract：:The 37K protein of Chinese wheat mosaic virus (CWMV) belongs to the 30K superfamily of plant virus movement proteins. CWMV 37K trans-complemented the cell-to-cell spread of a movement-defective Potato virus X. CWMV 37K fused to enhanced green fluorescent protein localized to plasmodesmata and formed endoplasmic reticu...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2012.10.024

    authors： Andika IB,Zheng S,Tan Z,Sun L,Kondo H,Zhou X,Chen J

    更新日期：2013-01-20 00:00:00

  • Combined results from solution studies on intact influenza virus M1 protein and from a new crystal form of its N-terminal domain show that M1 is an elongated monomer.

    abstract：:The amino-terminal domain of influenza A virus matrix protein (residues 1-164) was crystallized at pH 7 into a new crystal form in space group P1. This packing of the protein implies that M1(1-164) was monomeric in solution when it crystallized. Otherwise, the structure of the M1 fragment in the pH 7 crystals was the ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2000.0727

    authors： Arzt S,Baudin F,Barge A,Timmins P,Burmeister WP,Ruigrok RW

    更新日期：2001-01-20 00:00:00

  • Activation of both Wnt-1 and Fgf-3 by insertion of mouse mammary tumor virus downstream in the reverse orientation: a reappraisal of the enhancer insertion model.

    abstract：:In retrovirus-induced tumors, proviral DNA is commonly found next to or within a cellular proto-oncogene such that transcription of the gene is influenced by the viral promoter or enhancer. Extensive surveys of naturally occurring tumors reveal that proviruses integrated on the 3' side of the gene are usually in the s...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1993.1245

    authors： Clausse N,Baines D,Moore R,Brookes S,Dickson C,Peters G

    更新日期：1993-05-01 00:00:00

  • An Autographa californica nucleopolyhedrovirus lef-2 mutant: consequences for DNA replication and very late gene expression.

    abstract：:In order to define factors involved in very late Autographa californica nucleopolyhedrovirus (AcMNPV) gene function, random mutagenesis of a baculovirus recombinant (AcUW1.lacZ) by 5'-bromodeoxyuridine treatment was performed. Five viruses were selected with deficiencies in very late gene expression. These were charac...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1996.0121

    authors： Merrington CL,Kitts PA,King LA,Possee RD

    更新日期：1996-03-01 00:00:00

  • Construction of an infectious DNA clone of the full-length human spumaretrovirus genome and mutagenesis of the bel 1 gene.

    abstract：:An infectious and full-length molecular clone of genomic human spumaretrovirus (HSRV) DNA was constructed. The infectivity of the pHSRV13 clone was demonstrated after transfection into susceptible cells by passage of HSRV-specific cytopathic effects as a cell-free culture supernatant, by electron microscopy of HSRV pa...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(91)90820-2

    authors： Löchelt M,Zentgraf H,Flügel RM

    更新日期：1991-09-01 00:00:00

  • Effects of mutations in the C-terminal region of NIa protease on cis-cleavage between NIa and NIb.

    abstract：:Mutational analyses were carried out to investigate whether the nuclear inclusion protein a (NIa) C-terminal amino acids of turnip mosaic potyvirus play any roles in the cis-cleavage between NIa and NIb. The processing rate of the NIa-NIb junction sequence was decreased significantly by either V240D or Q243A mutation ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1997.8938

    authors： Kim DH,Han JS,Lew J,Kim SS,Kang BH,Hwang DC,Jang DS,Kim W,Song BD,Choi KY

    更新日期：1998-02-01 00:00:00

  • Mapping of the red clover necrotic mosaic virus subgenomic RNA.

    abstract：:The red clover necrotic mosaic dianthovirus capsid protein is expressed in vivo from a subgenomic RNA (sgRNA) identical to the 3'-terminal 1.5 kb of RNA-1. The 5' leader sequence of the capsid protein sgRNA is 62 nucleotides, contains a 14-nucleotide putative promoter sequence homologous to the RNA-1 5' terminus, and ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1996.0076

    authors： Zavriev SK,Hickey CM,Lommel SA

    更新日期：1996-02-15 00:00:00

  • ParAB-mediated intermolecular association of plasmid P1 parS sites.

    abstract：:The P1 plasmid partition system depends on ParA-ParB proteins acting on centromere-like parS sites for a faithful plasmid segregation during the Escherichia coli cell cycle. In vivo we placed parS into host E. coli chromosome and on a Sop(+) F plasmid and found that the stability of a P1 plasmid deleted for parA-parB ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2011.09.027

    authors： Kaur T,Al Abdallah Q,Nafissi N,Wettig S,Funnell BE,Slavcev RA

    更新日期：2011-12-20 00:00:00

  • The non-nucleoside reverse transcriptase inhibitor efavirenz stimulates replication of human immunodeficiency virus type 1 harboring certain non-nucleoside resistance mutations.

    abstract：:We measured the effects of non-nucleoside reverse transcriptase (RT) inhibitor-resistant mutations K101E+G190S, on replication fitness and EFV-resistance of HIV(NL4-3). K101E+G190S reduced fitness in the absence of EFV and increased EFV resistance, compared to either single mutant. Unexpectedly, K101E+G190S also repli...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2010.03.018

    authors： Wang J,Liang H,Bacheler L,Wu H,Deriziotis K,Demeter LM,Dykes C

    更新日期：2010-07-05 00:00:00

  • Antigenic variation in the hemagglutinin-neuraminidase protein of human parainfluenza type 3 virus.

    abstract：:Sixteen monoclonal antibodies directed to the hemagglutinin-neuraminidase (HN) protein of a 1957 isolate of parainfluenza type 3 virus (PIV3) were produced and used to examine antigenic variation in clinical strains. Analysis of hemagglutination-inhibition reactivity patterns of antigenic variants selected in vitro in...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(85)90395-2

    authors： van Wyke Coelingh KL,Winter C,Murphy BR

    更新日期：1985-06-01 00:00:00

  • Structure of the M2 protein gene of sonchus yellow net virus.

    abstract：:The nucleotide sequence of the gene immediately following the nucleocapsid protein gene of sonchus yellow net virus (SYNV), a plant rhabdovirus, is presented. Serological reactions of SYNV proteins with antibodies elicited by a fusion protein constructed from the sequenced gene indicate that this gene encodes an SYNV ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(87)90190-5

    authors： Heaton LA,Zuidema D,Jackson AO

    更新日期：1987-11-01 00:00:00

  • Viral fitness implications of variation within an immunodominant CD8+ T-cell epitope of HIV-1.

    abstract：:Cytotoxic T-lymphocyte (CTL) epitopes within the HIV genome are subject to negative and positive selective pressures, the balance of which influences CTL escape at a given epitope. We investigated whether viral fitness requirements dictate conservation of the HLA-A2 restricted immunodominant epitope SLYNTVATL (SL9). V...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2009.03.003

    authors： Christie NM,Willer DO,Lobritz MA,Chan JK,Arts EJ,Ostrowski MA,Cochrane A,Luscher MA,MacDonald KS

    更新日期：2009-05-25 00:00:00

  • Homologous and heterologous complementation of HBV and WHV capsid and polymerase functions in RNA encapsidation.

    abstract：:Successful encapsidation of hepadnaviral pregenomic RNA requires the orchestrated interaction of the viral capsid and polymerase proteins with each other and with the RNA packaging substrate. The early steps of this process involve binding of the polymerase to the encapsidation signal, epsilon, and are already underst...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1996.0260

    authors： Ziermann R,Ganem D

    更新日期：1996-05-15 00:00:00

  • Differentiation of acid-pH-dependent and -nondependent entry pathways for mouse hepatitis virus.

    abstract：:Early events of infection of MHV were studied in comparison with those of VSV, which is known to enter cells by an endocytic pathway. Treatment of mouse L-2 fibroblasts with ammonium chloride, chloroquine, or dansylcadaverine inhibited infection of MHV to a much lesser degree than that of VSV, suggesting a relatively ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(91)90014-3

    authors： Kooi C,Cervin M,Anderson R

    更新日期：1991-01-01 00:00:00

  • A conserved leucine that constricts the pore through the capsid fivefold cylinder plays a central role in parvoviral infection.

    abstract：:The atomic structure of the DNA-containing T = 1 particle of the parvovirus minute virus of mice (MVM) reveals cylindrical projections at each fivefold symmetry axis, each containing an 8 Angstrom pore through which runs 10 amino acids of a single VP2 N-terminus. The tightest constriction of this pore is formed at its...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2004.03.006

    authors： Farr GA,Tattersall P

    更新日期：2004-06-01 00:00:00

  • The coat protein of beet curly top virus is essential for infectivity.

    abstract：:We have applied the procedure of Agrobacterium-mediated inoculation to develop a simple, efficient, and reproducible assay for the infectivity of the leafhopper-transmitted geminivirus, beet curly top virus (BCTV). This assay system was used to show that a coat protein mutant of BCTV is not infectious, but could be co...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(89)90205-5

    authors： Briddon RW,Watts J,Markham PG,Stanley J

    更新日期：1989-10-01 00:00:00

  • Essential role of the unordered VP2 n-terminal domain of the parvovirus MVM capsid in nuclear assembly and endosomal enlargement of the virion fivefold channel for cell entry.

    abstract：:The unordered N-termini of parvovirus capsid proteins (Nt) are translocated through a channel at the icosahedral five-fold axis to serve for virus traffick. Heterologous peptides were genetically inserted at the Nt of MVM to study their functional tolerance to manipulations. Insertion of a 5T4-single-chain antibody at...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2012.05.025

    authors： Sánchez-Martínez C,Grueso E,Carroll M,Rommelaere J,Almendral JM

    更新日期：2012-10-10 00:00:00

  • Selection and partial characterization of dengue 2 virus mutants that induce fusion at elevated pH.

    abstract：:Two types of dengue (DEN) 2 virus mutants were selected either by repeated exposure to acidic pH (acid mutant, AM), or by the addition of ammonium chloride to Aedes albopictus C6/36 cells prior to and during viral infection (fusion mutant, FM). Both mutants grew more slowly than the parent strain and induced smaller p...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1993.1252

    authors： Guirakhoo F,Hunt AR,Lewis JG,Roehrig JT

    更新日期：1993-05-01 00:00:00

  • Geographic distribution and evolution of Ross River virus in Australia and the Pacific Islands.

    abstract：:We examined the molecular epidemiology and evolution of Ross River (RR) virus in Australia and the Pacific Islands. Nucleotide sequences of the E2 and E3 genes of five RR virus strains revealed remarkable conservation between 1959 and 1989 with a maximum divergence of only 3.3%. Sequence data from a 505-base pair frag...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1995.1449

    authors： Sammels LM,Coelen RJ,Lindsay MD,Mackenzie JS

    更新日期：1995-09-10 00:00:00

  • Plasticity of a critical antigenic determinant in the West Nile virus NY99 envelope protein domain III.

    abstract：:West Nile virus (WNV) is a mosquito-borne flavivirus that causes febrile illness, encephalitis, and occasionally death in humans. The envelope protein is the main component of the WNV virion surface, and domain III of the envelope protein (EIII) is both a putative receptor binding domain and a target of highly specifi...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2016.05.024

    authors： Plante JA,Torres M,Huang CY,Beasley DWC

    更新日期：2016-09-01 00:00:00

  • Characterization of Frog Virus 3 knockout mutants lacking putative virulence genes.

    abstract：:To identify ranavirus virulence genes, we engineered Frog Virus 3 (FV3) knockout (KO) mutants defective for a putative viral caspase activation and recruitment domain-containing (CARD) protein (Δ64R-FV3) and a β-hydroxysteroid dehydrogenase homolog (Δ52L-FV3). Compared to wild type (WT) FV3, infection of Xenopus tadpo...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2015.07.011

    authors： Andino Fde J,Grayfer L,Chen G,Chinchar VG,Edholm ES,Robert J

    更新日期：2015-11-01 00:00:00