Abstract:
:West Nile virus (WNV) is a mosquito-borne flavivirus that causes febrile illness, encephalitis, and occasionally death in humans. The envelope protein is the main component of the WNV virion surface, and domain III of the envelope protein (EIII) is both a putative receptor binding domain and a target of highly specific, potently neutralizing antibodies. Envelope E-332 (E-332) is known to have naturally occurring variation and to be a key determinant of neutralization for anti-EIII antibodies. A panel of viruses containing all possible amino acid substitutions at E-332 was constructed. E-332 was found to be highly tolerant of mutation, and almost all of these changes had large impacts on antigenicity of EIII but only limited effects on growth or virulence phenotypes.
journal_name
Virologyjournal_title
Virologyauthors
Plante JA,Torres M,Huang CY,Beasley DWCdoi
10.1016/j.virol.2016.05.024subject
Has Abstractpub_date
2016-09-01 00:00:00pages
97-105eissn
0042-6822issn
1096-0341pii
S0042-6822(16)30133-7journal_volume
496pub_type
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