Abstract:
:Circoviruses are relatively novel pathogens with increased importance in canids. In this study, we first screened the presence of dog circovirus (DogCV) by molecular methods from a total number of 389 internal organ samples originating from 277 individuals of domestic dogs and wild animals including wolves, foxes and badgers. All the animals originated from Central-Southern Italy, specifically from Abruzzi and Molise regions, areas hosting several natural parks. DogCV was detected in 9/34 wolves (P=26.4%; IC 95%: 14.6-43.1%), 8/209 dogs (P=3.8%; IC 95%: 1.9-7.3%), 0/24 foxes (P=0%; IC 95%: 0-13.8%), 1/10 badgers (P=10%; IC 95%: 1.79-40.4%). However, all DogCV positive animals were shown to be infected at least by an additional key pathogen, including canine distemper virus (CDV) and canine parvovirus type 2. All wolves, but one, presenting DogCV in the internal tissues suffered from CDV infection. The DNA purified from 17 DogCV infected organs was used for whole genome sequencing and phylogenetic analysis.
journal_name
Virologyjournal_title
Virologyauthors
Zaccaria G,Malatesta D,Scipioni G,Di Felice E,Campolo M,Casaccia C,Savini G,Di Sabatino D,Lorusso Adoi
10.1016/j.virol.2016.01.007subject
Has Abstractpub_date
2016-03-01 00:00:00pages
69-74eissn
0042-6822issn
1096-0341pii
S0042-6822(16)00010-6journal_volume
490pub_type
杂志文章相关文献
VIROLOGY文献大全abstract::Polyomavirus (PyV) infection induces protective T-cell-independent (TI) IgM and IgG responses in T-cell-deficient (TCR beta x delta-/-) mice. In this study, we show that PyV is a TI -2 antigen: B cells with a mutated Bruton's tyrosine kinase (Xid mutants) do not respond to PyV with antibody secretion in the absence of...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2000.0766
更新日期:2001-02-15 00:00:00
abstract::Open reading frames identified on the four genomic RNAs of beet necrotic yellow vein virus were cloned into bacterial expression vectors and resulting cl-fusion proteins expressed in Escherichia coli were used to raise polyclonal antibodies. This set of antisera was used to show the presence of 7 of 9 predicted viral ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(90)90378-5
更新日期:1990-09-01 00:00:00
abstract::Infection of mice with coxsackievirus B4 results within days in a severe acute necrotizing pancreatitis, which resolves completely within weeks. Gelatinase B or matrix metalloproteinase 9 (MMP-9) has previously been shown to be involved in several models of pancreatitis, but its role in virus-induced pancreatitis has ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2008.08.046
更新日期:2008-12-05 00:00:00
abstract::Geminiviruses constitute one of the largest groups of plant viruses, having characteristic twinned geminate particles encapsidating small circular single-stranded DNA molecules. Geminiviral promoters are generally located within the intergenic region, although promoters have also been detected within the genes. Simila...
journal_title:Virology
pub_type: 杂志文章,评审
doi:10.1016/j.virol.2016.04.033
更新日期:2016-08-01 00:00:00
abstract::Ubiquitin C-terminal Hydrolase L1 (UCH-L1) has oncogenic properties and is highly expressed during malignancies. We recently documented that Epstein-Barr virus (EBV) infection induces uch-l1 expression. Here we show that Kaposi's Sarcoma-associated herpesvirus (KSHV) infection induced UCH-L1 expression, via cooperatio...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.10.018
更新日期:2014-01-05 00:00:00
abstract::The protruding (P) domain of norovirus VP1 is responsible for immune recognition and host receptor interaction. Our previous studies have demonstrated that a modification of the ends of the P domain affects the conformation and/or function of the P protein. An expression of the P domain with or without the hinge, or w...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2010.11.017
更新日期:2011-02-20 00:00:00
abstract::Hantaan virus, the prototype virus of hemorrhagic fever with renal syndrome, was examined for nucleic acid characteristics which would support its previously proposed inclusion in the virus family Bunyaviridae. Nucleocapsid RNA from Hantaan virions and a control bunyavirus were examined for ribonuclease A (RNase A) se...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(83)90514-7
更新日期:1983-12-01 00:00:00
abstract::Two types of dengue (DEN) 2 virus mutants were selected either by repeated exposure to acidic pH (acid mutant, AM), or by the addition of ammonium chloride to Aedes albopictus C6/36 cells prior to and during viral infection (fusion mutant, FM). Both mutants grew more slowly than the parent strain and induced smaller p...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1993.1252
更新日期:1993-05-01 00:00:00
abstract::The identification of mechanisms that prevent infection with human immunodeficiency virus (HIV) or simian immunodeficiency virus (SIV) would facilitate the development of an effective AIDS vaccine. In time-course experiments, protection against detectable superinfection with homologous wild-type SIV was achieved withi...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2004.09.026
更新日期:2004-12-05 00:00:00
abstract::The cellular protein MDM2 can bind to the tumor suppressor gene product p53 and abrogate its transcriptional activity. In addition, p53 can regulate expression of the mdm2 gene. We and others have previously shown that p53 is present at high levels in adenovirus-transformed cells which express the larger E1B protein. ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1995.1349
更新日期:1995-07-10 00:00:00
abstract::G1/S transition of the cell cycle is blocked when cells are cultured without cell adhesion, even if nutrients and serum are present. Shift experiments involving transfer from adhesion to suspension cultures have revealed that cell adhesion in the early half of G1 phase is required for induction of DNA synthesis. We fo...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1996.0591
更新日期:1996-11-01 00:00:00
abstract::Hypervariable region 1 (HVR1) proteins of hepatitis C virus (HCV) have been reported to react broadly with sera of patients with HCV infection. However, the variability of the broad reactivity of individual HVR1 proteins has not been elucidated. We assessed the reactivity of 25 different HVR1 proteins (genotype 1b) wi...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1999.0004
更新日期:1999-11-10 00:00:00
abstract::GV1B is one of five viroids that have recently been purified from grapevines. GV1B has now been sequenced and its 363 nucleotide residues can potentially form the typical rod-like structure of viroids with 67% of nucleotides base-paired. GV1B has highest sequence similarity with grapevine yellow speckle viroid (GYSV; ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(89)90450-9
更新日期:1989-06-01 00:00:00
abstract::We produced the putative protease 3C of human rhinovirus 1A (HRV-1A), a minor group rhinovirus, by Escherichia coli expression of a segment of HRV-1A cDNA coding for 3A, 3B, 3C, and parts of 2C and 3D (delta 2C3ABC delta 3D). The protease 3C was expected to be processed by intramolecular Q-G cleavages from the virus-s...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(91)90429-f
更新日期:1991-10-01 00:00:00
abstract::Based on our previous analysis of HIV-1 isolates from Cameroon, we constructed a full-length infectious molecular clone from a primary isolate belonging to the CRF02.AG group of recombinant viruses which dominate the HIV-epidemic in West and Central Africa. The virus derived by transfection of the proviral clone pBD6-...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/s0042-6822(03)00381-7
更新日期:2003-09-01 00:00:00
abstract::Recent studies have shown enhanced antitumor efficacy with adenoviruses that either lack E1B-19K or overexpress E3-11.6K (also known as adenoviral death protein). E1B-19K is a well-characterized anti-apoptotic protein, and viruses with E1B-19K deletions show increased cytopathicity. However, the mechanism of cell kill...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2004.06.007
更新日期:2004-09-01 00:00:00
abstract::Encephalomyocarditis virus (EMCV) is the prototype member of the cardiovirus genus of picornaviruses. For cardioviruses and the related aphthoviruses, the first protein segment translated from the plus-strand RNA genome is the Leader protein. The aphthovirus Leader (173-201 amino acids) is an autocatalytic papain-like...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2001.1193
更新日期:2001-11-25 00:00:00
abstract::All lepidopteran baculovirus genomes sequenced to date encode a viral fibroblast growth factor homolog (vfgf), suggesting that vfgf may play an important role in the infection cycle of lepidopteran baculoviruses. Here, we describe the characterization of a Bombyx mori nucleopolyhedrovirus (BmNPV) mutant lacking functi...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2006.07.008
更新日期:2006-11-10 00:00:00
abstract::Pseudorabies virus (PRV) China reference strain Ea is genetically closely related to newly emerged variants; however, there is limited information about PRV Ea. Here, we compared PRV Ea with new variant strains by growth kinetics, genome sequencing, and protein expression analysis. Growth analysis showed that strain E...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2017.03.013
更新日期:2017-06-01 00:00:00
abstract::Porcine circovirus 2 (PCV2) has a major impact on the swine industry. Eight PCV2 genotypes (a-h) have been identified using capsid sequence analysis. PCV2d has been designated as the emerging genotype. The cryo-electron microscopy molecular envelope of PCV2d virus-like particles identifies differences between PCV2a, b...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.09.001
更新日期:2019-11-01 00:00:00
abstract::To determine whether infection with HIV-1 strains of different tropisms would influence expression of the mucosa-associated integrins alpha 4 beta 7 and alpha E beta 7 or the lymph node homing receptor L-selectin on peripheral T lymphocytes, cells were infected with the CXCR4-tropic (X4)/syncytium-inducing (SI) HIV-1(...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2000.0781
更新日期:2001-02-15 00:00:00
abstract::Tombusviruses, of which tomato bushy stunt virus (TBSV) is the type member, spontaneously generate defective interfering RNAs (DIs) that are known to interfere with viral accumulation and symptom development. We show that co-infection with TBSV and DIs causes a dramatic reduction in accumulation of TBSV subgenomic RNA...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1995.1410
更新日期:1995-08-01 00:00:00
abstract::We have previously shown that peroxisome proliferator-activated receptor-gamma (PPARgamma) agonists inhibited the inflammatory response of RSV-infected human lung epithelial cells. In this study, we supply evidence that specific PPARgamma agonists (15d-PGJ2, ciglitazone, troglitazone, Fmoc-Leu) efficiently blocked the...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2006.03.008
更新日期:2006-07-05 00:00:00
abstract::Hantaviruses are enveloped RNA viruses that belong to the family Bunyaviridae. They are the causative agents of hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). Hantaviruses show a worldwide distribution with specific rodent species as natural hosts. It is known that rodents can tr...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2003.09.006
更新日期:2004-01-05 00:00:00
abstract::It is well established that the human subgroup C adenovirus type 5 (Ad5) E1B 55 kDa protein can regulate the activity and concentration of the cellular tumor suppressor, p53. However, the contribution(s) of these functions of the E1B protein to viral reproduction remains unclear. To investigate this issue, we examined...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2008.06.016
更新日期:2008-09-01 00:00:00
abstract::During abortive infection of Go/G1-arrested primary baby mouse kidney (BMK) cell cultures with simian virus 40 (SV40), expression of the viral large T antigen is followed by a mitotic host response including the stimulation of host macromolecular synthesis and induction into the cell cycle of Go/G1-arrested cells. We ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(85)90130-8
更新日期:1985-12-01 00:00:00
abstract::In this study, we investigated the autoimmune response in rabbit ovaries following infection with a recombinant myxoma virus expressing rabbit zona pellucida protein B (MV-ZPB). A specific IgG antibody response to ZPB was elicited in the serum of infected rabbits and the antibody strongly bound to the zona pellucida o...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2003.10.021
更新日期:2004-01-20 00:00:00
abstract::The effects of P2 prophage on lambda-mediated depression of host metabolism, and on lambda macromolecular synthesis have been studied. Experiments employing certain lambdabio deletion mutants and lambda-related phages suggest that the same gene products are involved in inhibition of host metabolism (Hin+ function) and...
journal_title:Virology
pub_type: 杂志文章
doi:
更新日期:1971-11-01 00:00:00
abstract::During replication, the lengthy genome of dsDNA viruses is translocated with remarkable velocity into the limited space within the preformed procapsid. We previously found that a viral-encoded RNA (pRNA) played a key role in bacterial virus phi29 DNA translocation. Design of mutant pRNA sets containing two and three i...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2000.0771
更新日期:2001-03-15 00:00:00
abstract::The human papillomavirus type 16 E1--E4 protein is expressed abundantly in cells supporting viral DNA amplification, but its expression is lost during malignant progression. In cell culture, 16E1--E4 causes G2 cell cycle arrest by associating with and preventing the nuclear entry of Cdk1/cyclin B1 complexes. Here, we ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2006.02.024
更新日期:2006-05-25 00:00:00