Abstract:
:Epstein-Barr virus (EBV) is widely spread in the human population. EBV nuclear antigen 1 (EBNA1) is a transcription factor that activates viral genes and is necessary for viral replication and partitioning, which binds the EBV genome cooperatively. We identify similar EBNA1 repeat binding sites in the human genome using a nearest-neighbor positional weight matrix. Previously experimentally verified EBNA1 sites in the human genome are successfully recovered by our approach. Most importantly, 40 novel regions are identified in the human genome, constituted of tandemly repeated binding sites for EBNA1. Genes located in the vicinity of these regions are presented as possible targets for EBNA1-mediated regulation. Among these, four are discussed in more detail: IQCB1, IMPG1, IRF2BP2 and TPO. Incorporating the cooperative actions of EBNA1 is essential when identifying regulatory regions in the human genome and we believe the findings presented here are highly valuable for the understanding of EBV-induced phenotypic changes.
journal_name
Virologyjournal_title
Virologyauthors
d'Hérouël AF,Birgersdotter A,Werner Mdoi
10.1016/j.virol.2010.06.040subject
Has Abstractpub_date
2010-09-30 00:00:00pages
524-9issue
2eissn
0042-6822issn
1096-0341pii
S0042-6822(10)00422-8journal_volume
405pub_type
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