Abstract:
:The 24,000-molecular-weight major internal protein (p24) and the 15,000-molecular-weight nucleic acid binding protein (p15) of human T-cell leukemia virus type II (HTLV-II) were subjected to amino acid composition and amino-terminal amino acid sequence analysis. A comparison of amino acid composition of p24 and p15 of HTLV-II with those of the analogous proteins of HTLV-I revealed that these two proteins share overall similarity. Further, alignment of the amino-terminal amino acid sequence for the first 27 residues of p24 and 34 residues of p15 from HTLV-II showed extensive sequence homology with analogous proteins of HTLV-I. These data suggest that although disease associated with HTLV-I is malignant T-cell leukemia and that associated with HTLV-II is a relatively benign variant of hairy-cell leukemia, HTLV-I and HTLV-II are closely related to each other, at least in their gag-gene-encoded sequences.
journal_name
Virologyjournal_title
Virologyauthors
Devare SG,Kim Y,Fox JL,Getchell J,Cabradilla C,Kalyanaraman VSdoi
10.1016/0042-6822(85)90434-9subject
Has Abstractpub_date
1985-04-15 00:00:00pages
206-10issue
1eissn
0042-6822issn
1096-0341journal_volume
142pub_type
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