Abstract:
:It was previously reported that integrins alpha2beta1, alpha4beta1, and alphaXbeta2 are involved in rotavirus cell infection. In this work we studied the role of integrin subunits alpha2, alpha4, and beta2 on the attachment of rotaviruses RRV and nar3 to MA104 cells. Integrin alpha2beta1 was found to serve as the binding receptor for the neuraminidase-resistant virus nar3, whereas the neuraminidase-sensitive strain RRV interacted with this integrin at a postattachment step. It was shown that nar3 binds alpha2beta1 through the DGE integrin-recognition motif located in the virus surface protein VP5. Integrin subunits alpha4 and beta2 do not seem to be involved in the initial cell binding of either virus.
journal_name
Virologyjournal_title
Virologyauthors
Zárate S,Espinosa R,Romero P,Guerrero CA,Arias CF,López Sdoi
10.1006/viro.2000.0660subject
Has Abstractpub_date
2000-12-05 00:00:00pages
50-4issue
1eissn
0042-6822issn
1096-0341pii
S0042-6822(00)90660-3journal_volume
278pub_type
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