Abstract:
:HIV CRF07 B'/C is a strain circulating mainly in northwest region of China. The gp41 region of CRF07 is derived from a clade C virus. In order to compare the difference of CRF07 gp41 with that of typical clade B virus, we solved the crystal structure of the core region of CRF07 gp41. Compared with clade B gp41, CRF07 gp41 evolved more basic and hydrophilic residues on its helix bundle surface. Based on sequence alignment, a hyper-mutant cluster located in the middle of HR2 heptads repeat was identified. The mutational study of these residues revealed that this site is important in HIV mediated cell-cell fusion and plays critical roles in conformational changes during viral invasion.
journal_name
Virologyjournal_title
Virologyauthors
Du J,Xue H,Ma J,Liu F,Zhou J,Shao Y,Qiao W,Liu Xdoi
10.1016/j.virol.2013.07.024subject
Has Abstractpub_date
2013-11-01 00:00:00pages
86-94issue
1-2eissn
0042-6822issn
1096-0341pii
S0042-6822(13)00444-3journal_volume
446pub_type
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