Homologous recombination between a lactococcal bacteriophage and the chromosome of its host strain.

abstract：:The current antiretroviral therapy (ART) can effectively reduce plasma HIV loads to undetectable levels, but cannot eliminate latently infected resting memory CD4 T cells that persist for the lifetime of infected patients. Therefore, designing new therapeutic approaches to eliminate these latently infected cells or th...

journal_title：Virology

authors： Sahu GK,Sango K,Selliah N,Ma Q,Skowron G,Junghans RP

更新日期：2013-11-01 00:00:00

abstract：:Immunization with heat-inactivated herpes simplex virus type 1 (HSV-1) 2-5 days before ocular infection reduced the frequency of establishment of latent HSV-1 infection in the trigeminal ganglion (TG); this induction of resistance coincided with reduced expression of IFN-gamma mRNA in the TG. Immunization with unrelat...

journal_title：Virology

authors： Halford WP,Veress LA,Gebhardt BM,Carr DJ

更新日期：1997-09-29 00:00:00

abstract：:All lepidopteran baculovirus genomes sequenced to date encode a viral fibroblast growth factor homolog (vfgf), suggesting that vfgf may play an important role in the infection cycle of lepidopteran baculoviruses. Here, we describe the characterization of a Bombyx mori nucleopolyhedrovirus (BmNPV) mutant lacking functi...

journal_title：Virology

authors： Katsuma S,Horie S,Daimon T,Iwanaga M,Shimada T

更新日期：2006-11-10 00:00:00

abstract：:Demyelination of the human peripheral nervous system (PNS) can be caused by diverse mechanisms including viral infection. Despite association of several viruses with the development of peripheral demyelination, animal models of the condition have been limited to disease that is either autoimmune or genetic in origin. ...

journal_title：Virology

authors： Drescher KM,Tracy SM

更新日期：2007-03-01 00:00:00

abstract：:A number of factors that affect genetic interaction during mixed infection with temperature-sensitive mutants of simian rotavirus SA11 have been examined. (1) Statistical analyses of recombination frequency (RF) indicated that (a) the variability noted in RF was not related to variations in experimental conditions and...

journal_title：Virology

authors： Ramig RF

更新日期：1983-05-01 00:00:00

abstract：:The 37K protein of Chinese wheat mosaic virus (CWMV) belongs to the 30K superfamily of plant virus movement proteins. CWMV 37K trans-complemented the cell-to-cell spread of a movement-defective Potato virus X. CWMV 37K fused to enhanced green fluorescent protein localized to plasmodesmata and formed endoplasmic reticu...

journal_title：Virology

authors： Andika IB,Zheng S,Tan Z,Sun L,Kondo H,Zhou X,Chen J

更新日期：2013-01-20 00:00:00

abstract：:Recent reports indicated that vaccinia virus late mRNAs contain a unique 5' poly(A) leader sequence and that the in vitro translation of these mRNAs may be relatively cap-independent. These observations led us to examine the possibility that the mechanism of inhibition of host protein synthesis by vaccinia virus, like...

journal_title：Virology

authors： Schnierle BS,Moss B

更新日期：1992-06-01 00:00:00

abstract：:Infection of Salmonella enterica with lytic mutants of either P22 or SE1 bacteriophages triggers the expression of its DNA damage-inducible SOS response through a lexA-dependent pathway. This induction of the SOS system strictly requires the presence of the bacteriophage kil gene. Accordingly, plasmid overexpression o...

journal_title：Virology

authors： Campoy S,Hervàs A,Busquets N,Erill I,Teixidó L,Barbé J

更新日期：2006-08-01 00:00:00

abstract：:An insertion mutation in the pol gene of Moloney murine leukemia virus (M-MuLV) was found to render the virus temperature-sensitive for replication. A provirus containing a 12-bp insertion at the boundary between the reverse transcriptase (RT) and integrase (IN) domains induced the formation of mutant virions containi...

journal_title：Virology

authors： Tanese N,Roth M,Epstein H,Goff SP

更新日期：1989-06-01 00:00:00

abstract：:We have characterized the fibergenes of adenovirus type 19p (Ad19p), Ad19a, and Ad37 by sequencing. The fiber genes of Ad19a and Ad37 are identical and only five amino acids differ comparing Ad19a/Ad37 with Ad19p. Based on the translated sequences we calculated the isoelectrical points (Ips) and found that the fiber k...

journal_title：Virology

authors： Arnberg N,Mei Yf,Wadell G

更新日期：1997-01-06 00:00:00

abstract：:We have previously demonstrated that the bZIP transcription factor CREB-2, also called ATF-4, trans-activates, in association with the viral protein Tax, the human T-cell leukemia virus type I (HTLV-I) promoter. In this study, we have examined whether CREB-2 acetylation affects transcriptional activation mediated by T...

journal_title：Virology

authors： Gachon F,Devaux C,Mesnard JM

更新日期：2002-08-01 00:00:00

abstract：:Previously a new small subclass of SV40 large T antigen with a high-binding affinity to living target cells was characterized (J. Lange-Mutschler and R. Henning, 1983, Virology 127, 333-344.) In the present study the external binding process, particularly the tight linkage of T antigen to lipid of the target cells, wa...

journal_title：Virology

authors： Lange-Mutschler J,Henning R

更新日期：1984-07-30 00:00:00

abstract：:Bovine herpesvirus 5 (BHV-5) is a neurovirulent alpha-herpesvirus that causes fatal encephalitis in calves. We previously demonstrated that deletion of a glycine-rich epitope in the gE ectodomain dramatically reduced BHV-5 neurovirulence. To investigate the role of gE cytoplasmic tail sequences in the neuropathogenesi...

journal_title：Virology

authors： Al-Mubarak A,Simon J,Coats C,Okemba JD,Burton MD,Chowdhury SI

更新日期：2007-09-01 00:00:00

abstract：:The alphaherpesviruses establish latent infections in sensory neuronal cells, during which a number of latency-associated RNA transcripts (LATs) are produced. The reasons for the production of the LATs, however, and the mechanism by which the LAT region of the genome remains active during latency are unknown. Here we ...

journal_title：Virology

authors： Coffin RS,Howard MK,Latchman DS

更新日期：1995-06-01 00:00:00

abstract：:Small non-coding microRNAs (miRNAs) can modulate the outcome of virus infection. Here we explore the role of miRNAs in insect-virus interactions, in vivo, using the natural Drosophila melanogaster-Drosophila C virus (DCV) model system. Comparison of the miRNA expression profiles in DCV-infected and uninfected flies sh...

journal_title：Virology

authors： Monsanto-Hearne V,Tham ALY,Wong ZS,Asgari S,Johnson KN

更新日期：2017-02-01 00:00:00

abstract：:HPV16 E6 deregulates G1/S cell cycle progression through p53 degradation preventing transcription of the CDK inhibitor p21(WAF1). However, additional mechanisms independent of p53 inactivation appear to exist. Here, we report that HPV16 E6 targets the cellular factor p150(Sal2), which positively regulates p21(WAF1) tr...

journal_title：Virology

authors： Parroche P,Touka M,Mansour M,Bouvard V,Thépot A,Accardi R,Carreira C,Roblot GG,Sylla BS,Hasan U,Tommasino M

更新日期：2011-09-01 00:00:00

abstract：:The v-erb B protein of avian erythroblastosis virus (AEV) possesses an associated protein kinase activity in vitro. Analysis of temperature-sensitive mutants, and nonconditional host range mutants of AEV demonstrated that there was no simple correlation between this autophosphorylation activity and the transformation ...

journal_title：Virology

authors： Hayman MJ,Kitchener G,Knight J,McMahon J,Watson R,Beug H

更新日期：1986-04-15 00:00:00

abstract：:Two cDNA clones, which hybridized in Northern blots to RNA segment 6 of the homologous avian-like group A rotavirus (RV) 993/83 and pigeon RV PO-13, but not to mammalian group A rotaviruses, were sequenced. The gene 6 sequence contained a single long open reading frame encoding a protein of 397 amino acids (total MW 4...

journal_title：Virology

authors： Rohwedder A,Irmak H,Werchau H,Brüssow H

更新日期：1993-08-01 00:00:00

abstract：:The details of intracellular transport pathways for glycosylated proteins remain incompletely described. We previously described a mutant Rous sarcoma virus envelope glycoprotein (gp), mu 26, with an altered membrane-spanning domain that was targeted to lysosomes after traversing the trans-Golgi. This mutant protein w...

journal_title：Virology

authors： Johnston PB,Dong JY,Hunter E

更新日期：1995-01-10 00:00:00

abstract：:Disruption of the perforin gene results in primary immunodeficiency and an increased susceptibility to opportunistic pathogens. Perforin-deficient (PKO) mice fail to clear primary lymphocytic choriomeningitis virus (LCMV) Armstrong, resulting in persistent infection and functional exhaustion of virus-specific CD8+ T c...

journal_title：Virology

authors： Humphreys TD,Khanolkar A,Badovinac VP,Harty JT

更新日期：2008-01-20 00:00:00

abstract：:The mechanism of trans-acting regulation of transcription from the long terminal repeat (LTR) of human immunodeficiency virus (HIV) has been investigated. The roles of the cis-acting elements within HIV LTR, as well as the trans-acting factors present in HIV-infected cells, have been evaluated by an in vitro transcrip...

journal_title：Virology

authors： Okamoto T,Benter T,Josephs SF,Sadaie MR,Wong-Staal F

更新日期：1990-08-01 00:00:00

abstract：:Recently, the product of equine herpesvirus type 1 (EHV-1) ORF1, a homolog to HSV-1 pUL56, was shown to modulate MHC-I expression and innate immunity. Here, we investigated modulation of respiratory epithelial immunity by EHV-1 pUL56 and compared responses to those of PBMCs, which are important target cells that allow...

journal_title：Virology

authors： Soboll Hussey G,Ashton LV,Quintana AM,Van de Walle GR,Osterrieder N,Lunn DP

更新日期：2014-09-01 00:00:00

abstract：:Lymphoid cell lines were derived from three avian leukosis virus (ALV)-induced lymphomas. These cell lines contained proviral DNA sequences integrated upstream from the c-myc proto-oncogene, expressed increased levels of c-myc RNA, and were tumorigenic in syngeneic animals. While cell surface immunoglobulin (IgM) was ...

journal_title：Virology

authors： Baba TW,Giroir BP,Humphries EH

更新日期：1985-07-15 00:00:00

abstract：:Progressive Multifocal Leukoencephalopathy (PML) is caused by lytic replication of JC virus (JCV) in specific cells of the central nervous system. Like other polyomaviruses, JCV encodes a large T-antigen helicase needed for replication of the viral DNA. Here, we report the development of a luciferase-based, quantitati...

journal_title：Virology

authors： Shin J,Phelan PJ,Chhum P,Bashkenova N,Yim S,Parker R,Gagnon D,Gjoerup O,Archambault J,Bullock PA

更新日期：2014-11-01 00:00:00

abstract：:Powassan virus (POWV, Flaviviridae: Flavivirus) is the sole North American member of the tick-borne encephalitis complex and consists of two distinct lineages that are maintained in ecologically discrete enzootic transmission cycles. The underlying genetic mechanisms that lead to niche partitioning in arboviruses are ...

journal_title：Virology

authors： Brackney DE,Brown IK,Nofchissey RA,Fitzpatrick KA,Ebel GD

更新日期：2010-07-05 00:00:00

abstract：:The close association between human papillomavirus type 16 and cervical cancer implies some role for the virus in the development of this cancer. It has been demonstrated that HPV-16 DNA sequences in the presence of activated ras are capable of transforming primary baby rat kidney cells. This communication describes t...

journal_title：Virology

authors： Banks L,Crawford L

更新日期：1988-07-01 00:00:00

abstract：:The complete sequence of the genome of the cherry strain of tomato bushy stunt virus (TBSV), a member of the tombusvirus group, was determined. A full-length clone of the genome containing a bacteriophage T7 RNA polymerase promoter was assembled from partial cDNA clones. In vitro transcripts of the genome, either with...

journal_title：Virology

authors： Hearne PQ,Knorr DA,Hillman BI,Morris TJ

更新日期：1990-07-01 00:00:00

abstract：:Serotype 4 rotavirus strains have been classified into two antigenic "subtypes" by a solid phase immune electron microscopy technique in which cross-absorbed animal polyclonal immune sera are used as the source of antibodies. The sequences of the gene encoding the outer capsid glycoprotein VP7 from a single serotype 4...

journal_title：Virology

authors： Green KY,Sarasini A,Qian Y,Gerna G

更新日期：1992-05-01 00:00:00

abstract：:We previously demonstrated that human parainfluenza virus type 2 (hPIV-2) induces RhoA activation, which promotes its growth. RhoA controls the equilibrium between globular and filamentous actin (F-actin). We found that F-actin formation is induced by wild type (wt) hPIV-2 infection, and that inhibition of F-actin for...

journal_title：Virology

authors： Ohta K,Matsumoto Y,Yumine N,Nishio M

更新日期：2018-11-01 00:00:00

abstract：:H4N8 subtype avian influenza viruses were isolated from shorebirds in eastern Hokkaido. All the isolates shared >99.7% nucleotide homology, and all the viral genes except for PB1 were highly related to those of A/red-necked stint/Australia/1/04. Thus, the isolates were regarded as PB1 reassortants. The most similar PB...

journal_title：Virology

authors： Bui VN,Ogawa H,Xininigen,Karibe K,Matsuo K,Awad SS,Minoungou GL,Yoden S,Haneda H,Ngo LH,Tamaki S,Yamamoto Y,Nakamura K,Saito K,Watanabe Y,Runstadler J,Huettmann F,Happ GM,Imai K

更新日期：2012-02-05 00:00:00