Nucleotide sequence of gene 6 of avian-like group A rotavirus 993/83.

abstract：:The genus Badnavirus is characterized by members that are genetically and serologically heterogeneous which presents challenges for their detection and characterization. The presence of integrated badnavirus-like sequences in some host species further complicates detection using PCR-based protocols. To address these c...

journal_title：Virology

authors： Sukal AC,Kidanemariam DB,Dale JL,Harding RM,James AP

更新日期：2019-03-01 00:00:00

abstract：:Measles virus (MV) inhibits lymphocyte function in patients, as well as in cells infected in vitro. The proliferation of phytohemagglutinin-stimulated T lymphocytes is suppressed by in vitro MV infection, as shown by the diminished incorporation of [3H]thymidine into DNA and the reduced frequency of cells in the S pha...

journal_title：Virology

authors： Yanagi Y,Cubitt BA,Oldstone MB

更新日期：1992-03-01 00:00:00

abstract：:A system to associate specific genome segments with viral phenotypes and to study factors influencing genome reassortment was developed for tomato spotted wilt Tospovirus (TSWV). Reassortant isolates were generated by co-inoculating a TSWV isolate, TSWV-D, with TSWV-10 or TSWV-MD. The parental origin of each genome se...

journal_title：Virology

authors： Qiu WP,Geske SM,Hickey CM,Moyer JW

更新日期：1998-04-25 00:00:00

abstract：:We previously described a thymus-tropic HIV-1 envelope (R3A Env) from a rapid progressor obtained at the time of transmission. An HIV-1 molecular recombinant with the R3A Env supported extensive replication and pathogenesis in the thymus and did not require Nef. Another Env from the same patient did not display the sa...

journal_title：Virology

authors： Meissner EG,Coffield VM,Su L

更新日期：2005-06-05 00:00:00

abstract：:Epstein-Barr virus (EBV) is known to infect B cells and epithelial cells. We and others have shown that EBV can also infect a subset of thymocytes. Infection of thymocytes was accompanied by the appearance of linear EBV genome within 8 hr of infection. Circularization of the EBV genome was not detected. This is in con...

journal_title：Virology

authors： Kelleher CA,Paterson RK,Dreyfus DH,Streib JE,Xu JW,Takase K,Jones JF,Gelfand EW

更新日期：1995-04-20 00:00:00

abstract：:Mapping of the 5' ends of virion-derived hepatitis B virus DNA molecules was carried out after cloning and sequencing linearized genomes made fully double stranded. Of five clones obtained, three of four minus strand termini mapped to the G in position 1826 and one to the T in position 1827. Plus strand 5' ends were m...

journal_title：Virology

authors： Saldanha JA,Qiu H,Thomas HC,Monjardino J

更新日期：1992-05-01 00:00:00

abstract：:Sequence analysis of the mouse hepatitis virus, strain A59 (MHV-A59) genome predicts the presence of two papain-like proteinases encoded within the first open reading frame (ORF 1a) of the replicase gene. The more 5' of these domains, the leader papain-like proteinase, is responsible for the cleavage of the amino term...

journal_title：Virology

authors： Bonilla PJ,Hughes SA,Piñón JD,Weiss SR

更新日期：1995-06-01 00:00:00

abstract：:The 24,000-molecular-weight major internal protein (p24) and the 15,000-molecular-weight nucleic acid binding protein (p15) of human T-cell leukemia virus type II (HTLV-II) were subjected to amino acid composition and amino-terminal amino acid sequence analysis. A comparison of amino acid composition of p24 and p15 of...

journal_title：Virology

authors： Devare SG,Kim Y,Fox JL,Getchell J,Cabradilla C,Kalyanaraman VS

更新日期：1985-04-15 00:00:00

abstract：:The mechanism and machinery of hepatitis C virus (HCV) RNA replication are still poorly characterized. Our previous study has shown that HCV RNA synthesis occurs on a lipid raft membrane structure [J. Virol. 77 (2003) 77 4160]. In this study, we further characterized these replication complexes (RCs) in Huh-7 cells th...

journal_title：Virology

authors： Aizaki H,Lee KJ,Sung VM,Ishiko H,Lai MM

更新日期：2004-07-01 00:00:00

abstract：:The Epstein-Barr virus (EBV) nuclear antigen EBNA-1 is essential for viral genome maintenance in vitro and may be the only EBV protein expressed by the majority of latently infected cells in vivo. EBNA-1 may therefore be critical to the evasion of host immunity which allows persistent infection. EBNA-1 includes a poly...

journal_title：Virology

authors： Wrightham MN,Stewart JP,Janjua NJ,Pepper SD,Sample C,Rooney CM,Arrand JR

更新日期：1995-04-20 00:00:00

abstract：:The 380-kb chlorella virus NY-2A genome is highly methylated; 45% of the cytosines are 5-methylcytosine (5mC) and 37% of the adenines are N6-methyladenine (6mA). Based on the sensitivity/resistance of NY-2A DNA to 80 methylation-sensitive DNA restriction endonucleases, the virus is predicted to encode at least 10 DNA ...

journal_title：Virology

authors： Zhang Y,Nelson M,Nietfeldt J,Xia Y,Burbank D,Ropp S,Van Etten JL

更新日期：1998-01-20 00:00:00

abstract：:Cells infected with a reassortant (113/Ho, H7N2) between A/fowl plague/Rostock/34 (FPV, H7N1) and A/Hong Kong/1/68 (H3N2) carrying RNA segments 1 and 6 of the Hong Kong virus and the residual genes of FPV, synthesized at 40 degrees a neuraminidase (NA) which is enzymatically not active and which is not incorporated in...

journal_title：Virology

authors： Breuning A,Scholtissek C

更新日期：1986-04-15 00:00:00

abstract：:We expressed the carboxy-terminal portion of the E2 open reading frame (ORF)-encoded protein of human papillomavirus type 16 (HPV-16) and purified it to near homogeneity. Using DNase I footprinting techniques, we show that like the homologous protein from bovine papillomavirus type 1 (BPV-1), HPV-18, HPV-11, it binds ...

journal_title：Virology

authors： Bedrosian CL,Bastia D

更新日期：1990-02-01 00:00:00

abstract：:The biological phenotype of HIV-1 isolates from 21 subjects with primary HIV-1 infection was determined in primary lymphocytes and monocyte-derived macrophages as well as in three T-cell lines (MT-2, HUT78, and C8166). Seven isolates (33%) replicated on at least one cell line and were classified as rapid/high (n = 6) ...

journal_title：Virology

authors： Fiore JR,Björndal A,Peipke KA,Di Stefano M,Angarano G,Pastore G,Gaines H,Fenyö EM,Albert J

更新日期：1994-10-01 00:00:00

abstract：:The single open reading frame (ORF) 5 encoding the 50-kDa protein of barley yellow dwarf virus PAV-IL (BYDV-PAV-IL) was expressed in bacteria, purified, and used as an immunogen/antigen to produce/screen antibodies specific to the 50-kDa protein. Two monoclonal antibodies (MAb PAV-IL-22 kDa and MAb PAV-IL-50 kDa) rais...

journal_title：Virology

authors： Cheng SL,Domier LL,D'Arcy CJ

更新日期：1994-08-01 00:00:00

abstract：:We used serial protein misfolding cyclic amplification (sPMCA) to amplify the D10 strain of CWD prions in a linear relationship over two logs of D10 dilutions. The resultant PMCA-amplified D10 induced terminal TSE disease in CWD-susceptible Tg(cerPrP)1536 mice with a survival time approximately 80 days shorter than th...

journal_title：Virology

authors： Meyerett C,Michel B,Pulford B,Spraker TR,Nichols TA,Johnson T,Kurt T,Hoover EA,Telling GC,Zabel MD

更新日期：2008-12-20 00:00:00

abstract：:Few human endogenous retroviruses (HERVs) have been extensively studied in non-human primates. Such investigations have demonstrated that several element classes are primate unique, contain members with important biological function, are conserved in specific primate lineages, and have in some cases expanded in copy n...

journal_title：Virology

authors： Greenwood AD,Stengel A,Erfle V,Seifarth W,Leib-Mösch C

更新日期：2005-04-10 00:00:00

abstract：:In the event of smallpox bioterrorism, widespread vaccination may be required. Vaccinia immune globulin (VIG) has been used to treat complications from the smallpox vaccine. While the potency of VIG was defined by its ability to neutralize intracellular mature virus, a second form of vaccinia called the extracellular ...

journal_title：Virology

authors： Bell E,Shamim M,Whitbeck JC,Sfyroera G,Lambris JD,Isaacs SN

更新日期：2004-08-01 00:00:00

abstract：:Antibodies against the L protein of Sendai virus were made by immunizing rabbits with a synthetic peptide representing a carboxyl-terminal region of the protein predicted from the base sequence of its gene. These antibodies were used to localize the L protein in viral nucleocapsids by electron microscopy. Immunogold l...

journal_title：Virology

authors： Portner A,Murti KG,Morgan EM,Kingsbury DW

更新日期：1988-03-01 00:00:00

abstract：:RSV is a major cause of severe lower respiratory infection in infants and young children. With no vaccine yet available, it is important to clarify mechanisms of disease pathogenesis. Since indoleamine-2,3-dioxygenase (IDO) is an immunomodulatory enzyme and is upregulated with RSV infection, we studied it in vivo duri...

journal_title：Virology

authors： Rajan D,Chinnadurai R,O'Keefe EL,Boyoglu-Barnum S,Todd SO,Hartert TV,Galipeau J,Anderson LJ

更新日期：2017-12-01 00:00:00

abstract：:Although rodents are important reservoirs for RNA viruses, to date only one species of rodent coronavirus (CoV) has been identified. Herein, we describe a new CoV, denoted Lucheng Rn rat coronavirus (LRNV), and novel variants of two Betacoronavirus species termed Longquan Aa mouse coronavirus (LAMV) and Longquan Rl ra...

journal_title：Virology

authors： Wang W,Lin XD,Guo WP,Zhou RH,Wang MR,Wang CQ,Ge S,Mei SH,Li MH,Shi M,Holmes EC,Zhang YZ

更新日期：2015-01-01 00:00:00

abstract：:We measured the effects of non-nucleoside reverse transcriptase (RT) inhibitor-resistant mutations K101E+G190S, on replication fitness and EFV-resistance of HIV(NL4-3). K101E+G190S reduced fitness in the absence of EFV and increased EFV resistance, compared to either single mutant. Unexpectedly, K101E+G190S also repli...

journal_title：Virology

authors： Wang J,Liang H,Bacheler L,Wu H,Deriziotis K,Demeter LM,Dykes C

更新日期：2010-07-05 00:00:00

abstract：:Replication of the satellite RNA of tobacco ringspot virus (sTobRV RNA) has been postulated to require rolling circle transcription. The expected product of rolling circle transcription, multimeric sTobRV RNA, is known to undergo self-cleavage in vitro to release unit-length sTobRV RNA. A spontaneous, efficient, not e...

journal_title：Virology

authors： Van Tol H,Buzayan JM,Bruening G

更新日期：1991-01-01 00:00:00

abstract：:EBNA-1 is the sole virally specified protein required for replication of the Epstein-Barr virus latency origin and also modulates its own expression. Both of these functions are mediated through specific DNA binding. We created a series of amino acid substitutions across the previously identified DNA-binding domain of...

journal_title：Virology

authors： Chen MR,Zong J,Hayward SD

更新日期：1994-12-01 00:00:00

abstract：:Temperate coliphage P2 integrates its genome into the host chromosome upon lysogenization via a site-specific recombination event mediated by an integrase belonging to the complex family of tyrosine recombinases. The host integration site attB (BOB') is localized in the end of the cyaR gene and shares 27 nucleotides w...

journal_title：Virology

authors： Sylwan L,Frumerie C,Haggård-Ljungquist E

更新日期：2010-09-01 00:00:00

abstract：:Whole genome sequences for three Epstein-Barr virus strains (B95-8, GD1 and AG876) were aligned and compared. In addition to known variable loci (including type-specific alleles for the EBNA2, EBNA3A, EBNA3B and EBNA3C genes, plus the EBNA1 and LMP1 genes), seven large-scale regions of lower-level diversity were ident...

journal_title：Virology

authors： McGeoch DJ,Gatherer D

更新日期：2007-03-01 00:00:00

abstract：:This work investigated whether the Escherichia coli RNase III gene, rnc+, could complement vp1080, a mutant vaccinia virus that is deleted of its E3L gene. Like E3L, rnc+ codes for a dsRNA binding protein that contains an additional nucleolytic activity. Rnc genes were cloned into the eukaryotic expression vector pMTV...

journal_title：Virology

authors： Shors T,Jacobs BL

更新日期：1997-01-06 00:00:00

abstract：:Trans-acting regulatory components of Autographa californica nuclear polyhedrosis virus (AcMNPV) were studied in a transient assay system for their ability to activate the p143 gene promoter. A region including 502 nt upstream of the AUG of the p143 gene was linked to the bacterial chloramphenicol acetyltransferase (C...

journal_title：Virology

authors： Lu A,Carstens EB

更新日期：1993-08-01 00:00:00

abstract：:We studied experimental canine oral papillomavirus (COPV) infection by in situ hybridization and immunohistochemistry of weekly biopsies. After 4 weeks, viral DNA in rete ridges suggested a keratinocyte stem cell target. Abundant viral DNA was seen in E4-positive cells only. E4 was predominantly cytoplasmic but also n...

journal_title：Virology

authors： Nicholls PK,Doorbar J,Moore RA,Peh W,Anderson DM,Stanley MA

更新日期：2001-05-25 00:00:00

abstract：:We have used cells infected with the HIV-1 molecular clone HX10 to study the binding of monoclonal antibodies (mAbs) to different epitopes within the extracellular domain of the HIV-1 transmembrane glycoprotein gp41. Gp41 mAb binding to the infected cells at 4 degrees was variable but weaker than the binding of an ant...

journal_title：Virology

authors： Sattentau QJ,Zolla-Pazner S,Poignard P

更新日期：1995-01-10 00:00:00