Abstract:
:Lymphoid cell lines were derived from three avian leukosis virus (ALV)-induced lymphomas. These cell lines contained proviral DNA sequences integrated upstream from the c-myc proto-oncogene, expressed increased levels of c-myc RNA, and were tumorigenic in syngeneic animals. While cell surface immunoglobulin (IgM) was expressed by all three cell lines, only one of the lines secreted IgM into the culture medium. Further, analysis by light microscopy and flow cytometry demonstrated that these cell lines exhibited two distinct morphological and light-scattering profiles. The two nonsecreting lines exhibited a lymphoblastoid phenotype, whereas, the secreting line possessed a more differentiated plasmacytoid phenotype. These findings implicate the activation of c-myc in the pathogenesis of tumors representing two distinct stages of B-cell differentiation within a single animal species.
journal_name
Virologyjournal_title
Virologyauthors
Baba TW,Giroir BP,Humphries EHdoi
10.1016/0042-6822(85)90312-5subject
Has Abstractpub_date
1985-07-15 00:00:00pages
139-51issue
1eissn
0042-6822issn
1096-0341journal_volume
144pub_type
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