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HIV-1 transgenic rats develop T cell abnormalities.

Abstract：

:HIV-1 infection leads to impaired antigen-specific T cell proliferation, increased susceptibility of T cells to apoptosis, progressive impairment of T-helper 1 (Th1) responses, and altered maturation of HIV-1-specific memory cells. We have identified similar impairments in HIV-1 transgenic (Tg) rats. Tg rats developed an absolute reduction in CD4+ and CD8+ T cells able to produce IFN-gamma following activation and an increased susceptibility of T cells to activation-induced apoptosis. CD4+ and CD8+ effector/memory (CD45RC- CD62L-) pools were significantly smaller in Tg rats compared to non-Tg controls, although the converse was true for the naïve (CD45RC+ CD62L+) T cell pool. Our interpretation is that the HIV transgene causes defects in the development of T cell effector function and generation of specific effector/memory T cell subsets, and that activation-induced apoptosis may be an essential factor in this process.

journal_name

Virology

journal_title

Virology

authors

Reid W,Abdelwahab S,Sadowska M,Huso D,Neal A,Ahearn A,Bryant J,Gallo RC,Lewis GK,Reitz M

doi

10.1016/j.virol.2003.12.010

subject

Has Abstract

pub_date

2004-03-30 00:00:00

pages

111-9

issue

1

eissn

0042-6822

issn

1096-0341

pii

S0042682204000054

journal_volume

321

pub_type

杂志文章

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