Lettuce infectious yellows virus (LIYV) RNA 1-encoded P34 is an RNA-binding protein and exhibits perinuclear localization.

abstract：:The amino acid sequence of the fiber from adenovirus type 5 has been deduced from the nucleotide sequence of the fiber gene. This sequence is compared with that of adenovirus type 2, a closely related serotype. We find 69% homology for the fiber protein whereas the known nonstructural proteins of these two serotypes h...

journal_title：Virology

authors： Chroboczek J,Jacrot B

更新日期：1987-12-01 00:00:00

abstract：:Serial passage of Ross River virus in chick embryo fibroblasts selected for virus variants altered in their reactions to neutralizing monoclonal antibodies. The E1 and E2 genes of each antigenic variant were sequenced; single nucleotide changes were found in E2 leading to amino acid substitutions at either residue 4 (...

journal_title：Virology

authors： Kerr PJ,Weir RC,Dalgarno L

更新日期：1993-03-01 00:00:00

abstract：:The pe38 gene product of Autographa californica M nucleopolyhedrovirus (AcMNPV) has been shown to be involved in transcriptionally transactivating viral genes and augmenting viral DNA replication in transient assays. To assess the role of pe38 during infection, we generated a knockout virus, Delta pe38-E9/E9, in which...

journal_title：Virology

authors： Milks ML,Washburn JO,Willis LG,Volkman LE,Theilmann DA

更新日期：2003-06-05 00:00:00

abstract：:Viruses were recovered from HeLa S3 cells and African green monkey kidney (AGMK) cells transfected with an infectious cDNA clone of poliovirus vaccine Sabin 1 strain. The viruses recovered from the different DNA-transfected cells were tested for the biological characteristics of temperature sensitivity (rct marker), p...

journal_title：Virology

authors： Kohara M,Abe S,Kuge S,Semler BL,Komatsu T,Arita M,Itoh H,Nomoto A

更新日期：1986-05-01 00:00:00

abstract：:Transcription of human papillomaviruses (HPV) is regulated by enhancer sequences located in the upstream regulatory region. The factors regulating expression of one of the high risk genital HPV types, HPV 31b, were investigated using transient expression and protein binding assays. A region of 262 base pairs in length...

journal_title：Virology

authors： Kyo S,Tam A,Laimins LA

更新日期：1995-08-01 00:00:00

abstract：:Alternative splicing of pre-mRNAs plays a critical role in maximizing the coding capacity of the small parvovirus genome. The small-intron region of minute virus of mice (MVM) pre-mRNAs undergoes an unusual pattern of overlapping alternative splicing, using two donors, D1 and D2, and two acceptors, A1 and A2, within a...

journal_title：Virology

authors： Haut DD,Pintel DJ

更新日期：1999-05-25 00:00:00

abstract：:Herpesvirus glycoprotein C (gC) functions as a major virus attachment protein. The gC sequence of the neurovirulent bovine herpesvirus type 5 (BHV-5) virus was determined and compared with the gC sequence of the nonneurovirulent BHV-1. Alignment of the predicted amino acid sequences of BHV-1 and BHV-5 gC ORFs showed t...

journal_title：Virology

authors： Chowdhury SI

更新日期：1995-11-10 00:00:00

abstract：:The pr55gag polyprotein of HIV-1 plays a critical role in the formation of immature virus particles in the cell and during the budding process. We investigated the influence of amino acid substitutions in the p24CA- region of the gag polyprotein on the viral assembly process. Deletion of the amino acids 341-352 in the...

journal_title：Virology

authors： von Poblotzki A,Wagner R,Niedrig M,Wanner G,Wolf H,Modrow S

更新日期：1993-04-01 00:00:00

abstract：:Ts1, a temperature-sensitive mutant of Moloney murine leukemia virus-TB (MoMuLV-TB), causes a progressive hindlimb paralytic disease in susceptible strains of mice. Previously, it has been shown that a single amino acid substitution, Val-25----Ile in gPr80env, is responsible for the temperature sensitivity, inefficien...

journal_title：Virology

authors： Kamps CA,Lin YC,Wong PK

更新日期：1991-10-01 00:00:00

abstract：:Herpes simplex virus mutant KG111 contains a nonsense mutation at codon 44 of the viral thymidine kinase (tk) gene and produces low amounts of a truncated tk polypeptide. We tested mutant KG111 and related viruses that specify varying amounts of similar truncated tk polypeptides for their sensitivities to antiviral nu...

journal_title：Virology

authors： Coen DM,Irmiere AF,Jacobson JG,Kerns KM

更新日期：1989-02-01 00:00:00

abstract：:Experiments were undertaken to determine if the sera of avian sarcoma virus-infected 15I5 X 7(2) chickens exhibit antibody reactivity for species of endogenous retroviral envelope glycoprotein expressed in 15I5 X 7(2) fibroblasts. Two viruses were used for infection of the 15I5 X 7(2) chickens, Pr-A and cl. 85; the en...

journal_title：Virology

authors： Halpern MS,Deery DT,Flores LJ,Fujita DJ,Mason WS

更新日期：1983-01-30 00:00:00

abstract：:Polyomavirus (PyV) infection induces protective T-cell-independent (TI) IgM and IgG responses in T-cell-deficient (TCR beta x delta-/-) mice. In this study, we show that PyV is a TI -2 antigen: B cells with a mutated Bruton's tyrosine kinase (Xid mutants) do not respond to PyV with antibody secretion in the absence of...

journal_title：Virology

authors： Szomolanyi-Tsuda E,Brien JD,Dorgan JE,Garcea RL,Woodland RT,Welsh RM

更新日期：2001-02-15 00:00:00

abstract：:A cytopathic infectious agent was isolated from the kidneys of an apparently healthy tree shrew (Tupaia belangeri) that had been captured in the area around Bangkok. The infectivity was propagated in Tupaia fibroblast and kidney cell cultures. Paramyxovirus-like pleomorphic enveloped particles and helical nucleocapsid...

journal_title：Virology

authors： Tidona CA,Kurz HW,Gelderblom HR,Darai G

更新日期：1999-06-05 00:00:00

abstract：:We previously described a thymus-tropic HIV-1 envelope (R3A Env) from a rapid progressor obtained at the time of transmission. An HIV-1 molecular recombinant with the R3A Env supported extensive replication and pathogenesis in the thymus and did not require Nef. Another Env from the same patient did not display the sa...

journal_title：Virology

authors： Meissner EG,Coffield VM,Su L

更新日期：2005-06-05 00:00:00

abstract：:Bovine respiratory disease (BRD) is the costliest disease affecting the cattle industry globally. Orthomyxoviruses, influenza C virus (ICV) and influenza D virus (IDV) have recently been implicated to play a role in BRD. However, there are contradicting reports about the association of IDV and ICV to BRD. Using the la...

journal_title：Virology

authors： Nissly RH,Zaman N,Ibrahim PAS,McDaniel K,Lim L,Kiser JN,Bird I,Chothe SK,Bhushan GL,Vandegrift K,Neibergs HL,Kuchipudi SV

更新日期：2020-12-01 00:00:00

abstract：:The incidence of head and neck squamous cell carcinomas (HNSCCs) is rising in developed countries. This is driven by an increase in HNSCCs caused by high-risk human papillomavirus (HPV) infections or HPV + HNSCCs. Compared to HNSCCs not caused by HPV (HPV- HNSCCs), HPV + HNSCCs are more responsive to therapy and assoc...

journal_title：Virology

authors： Holcomb AJ,Brown L,Tawfik O,Madan R,Shnayder Y,Thomas SM,Wallace NA

更新日期：2020-09-01 00:00:00

abstract：:JC virus (JCV) Agnoprotein (Agno) plays critical roles in successful completion of the viral replication cycle. Understanding its regulatory roles requires a complete map of JCV-host protein interactions. Here, we report the first Agno interactome with host cellular targets utilizing "Two-Strep-Tag" affinity purificat...

journal_title：Virology

authors： Saribas AS,Datta PK,Safak M

更新日期：2020-01-15 00:00:00

abstract：:Human cytomegalovirus (HCMV) was recently shown to encode a large number of spliced mRNAs. While the nuclear export of unspliced viral transcripts has been extensively studied, the role of host mRNA export factors in HCMV mRNA trafficking remains poorly defined. We found that the eIF4AIII RNA helicase, a component of ...

journal_title：Virology

authors： Ziehr B,Lenarcic E,Cecil C,Moorman NJ

更新日期：2016-02-01 00:00:00

abstract：:Many antiviral drugs must be metabolized to their active form by cellular enzymes. Their antiviral activity may therefore be limited by an inefficient metabolism, leading to low intracellular concentration of the active form or to the accumulation of toxic intermediate metabolites. Gene transfer might be used to overc...

journal_title：Virology

authors： Guettari N,Loubière L,Brisson E,Klatzmann D

更新日期：1997-09-01 00:00:00

abstract：:Interferon gamma (IFNγ) has complex immunomodulatory and antiviral properties. While IFNγ is detected in the airways in response to infection with the pneumovirus pathogen, pneumonia virus of mice (PVM; Family Paramyxoviridae), its role in promoting disease has not been fully explored. Here, we evaluate PVM infection ...

journal_title：Virology

authors： Glineur SF,Bowen AB,Percopo CM,Garcia-Crespo KE,Dyer KD,Ochkur SI,Lee NA,Lee JJ,Domachowske JB,Rosenberg HF

更新日期：2014-11-01 00:00:00

abstract：:Cell-to-cell and long-distance transport of some plant viruses requires coordinated action of three movement proteins encoded by triple gene block (TGB). The largest of TGB proteins, TGBp1, is a member of the superfamily I of DNA/RNA helicases and possesses a set of conserved helicase sequence motifs necessary for vir...

journal_title：Virology

authors： Kalinina NO,Rakitina DV,Solovyev AG,Schiemann J,Morozov SY

更新日期：2002-05-10 00:00:00

abstract：:Herpes simplex virus mutant strains that fail to encode a functional ICP27 polypeptide show a reduction in their ability to replicate viral DNA compared to wild-type virus. To define the nature of this defect, we examined the formation of viral DNA replication structures in the nucleus of cells infected with these mut...

journal_title：Virology

authors： Curtin KD,Knipe DM

更新日期：1993-09-01 00:00:00

abstract：:Sequence analysis of the murine gamma-herpesvirus 68 (gammaHV68) genome previously identified several open reading frames (ORFs) located at the left end of the viral genome that do not share homology with other known herpesvirus or cellular genes. Here, we show that one of these ORFs, M4, encodes a secreted glycoprote...

journal_title：Virology

authors： Evans AG,Moorman NJ,Willer DO,Speck SH

更新日期：2006-01-20 00:00:00

abstract：:Hepatitis A virus infection and growth in cultured cells is protracted, cell-type restricted, and generally not accompanied by the appearance of a cytopathic effect, with the exception of some culture-adapted strains. We demonstrate that the non-cytopathic HAV strain HM175/clone 1 can be induced to exhibit a cytopathi...

journal_title：Virology

authors： Wales SQ,Ngo D,Hida K,Kulka M

更新日期：2012-08-15 00:00:00

abstract：:Coronaviruses have a marked tropism for epithelial cells. Entry and release of the porcine transmissible gastroenteritis virus (TGEV) is restricted to apical surfaces of polarized epithelial cells, as we have recently shown (J. W. A. Rossen, C. P. J. Bekker, W. F. Voorhout, G. J. A. M. Strous, A. van der Ende, and P. ...

journal_title：Virology

authors： Rossen JW,Voorhout WF,Horzinek MC,van der Ende A,Strous GJ,Rottier PJ

更新日期：1995-06-20 00:00:00

abstract：:We compared the levels of the Ski oncoprotein, an inhibitor of transforming growth factor-beta (TGF-β) signaling, in normal human keratinocytes (HKc), HPV16 immortalized HKc (HKc/HPV16), and differentiation resistant HKc/HPV16 (HKc/DR) in the absence and presence of TGF-β. Steady-state Ski protein levels increased in ...

journal_title：Virology

authors： Chen Y,Pirisi L,Creek KE

更新日期：2013-09-01 00:00:00

abstract：:This work investigated whether the Escherichia coli RNase III gene, rnc+, could complement vp1080, a mutant vaccinia virus that is deleted of its E3L gene. Like E3L, rnc+ codes for a dsRNA binding protein that contains an additional nucleolytic activity. Rnc genes were cloned into the eukaryotic expression vector pMTV...

journal_title：Virology

authors： Shors T,Jacobs BL

更新日期：1997-01-06 00:00:00

abstract：:Flaviviruses are single-stranded positive RNA viruses that replicate through double stranded RNA (dsRNA) intermediates. These dsRNA may be recognized as pathogen-associated molecular patterns by cellular receptors including membrane-bound Toll-like receptor 3 (TLR3) and cytosolic helicases RIG-I and MDA5. dsRNA stimul...

journal_title：Virology

authors： Baronti C,Sire J,de Lamballerie X,Quérat G

更新日期：2010-09-01 00:00:00

abstract：:Two forms of JC virus (JCV) have been isolated from its human host, an archetype found in kidney tissue and urine of nonimmunocompromised individuals and a rearranged type detected in lymphocytes and brain tissue of patients with and without progressive multifocal leukoencephalopathy. To investigate the hypothesis tha...

journal_title：Virology

authors： Daniel AM,Swenson JJ,Mayreddy RP,Khalili K,Frisque RJ

更新日期：1996-02-01 00:00:00

abstract：:We mutagenized and characterized a 41-kilobase-pair subgenomic cloned fragment from the unique long (UL) region of pseudorabies virus (PRV). Forty mutant clones, each carrying a single inserted oligonucleotide, were used for cotransfection with overlapping cloned viral DNA fragments. More than half of these transfecti...

journal_title：Virology

authors： De Wind N,Peeters BP,Zuderveld A,Gielkens AL,Berns AJ,Kimman TG

更新日期：1994-05-01 00:00:00