Abstract:
:The induction of autoimmunity by viruses has been hypothesized to occur by a number of mechanisms. Coxsackievirus B4 (CB4) induces hyperglycemia in SJL mice resembling diabetes in humans. While virus is effectively cleared within 2 weeks, hyperglycemia does not appear until about 8-12 weeks postinfection at a time when replicative virus is no longer detectable. In SJL mice, reinfection with CB4 enhanced the development of hyperglycemia. As predicted, the immune system responded more rapidly to the second infection and virus was cleared more swiftly. However, while infiltrating T cells were found within the pancreas, depletion of the CD4 T cell population prior to secondary infection or use of CD8 knock-out mice had no effect on the development of virus-mediated hyperglycemia. In conclusion, enhanced hyperglycemia induced by CB4 occurs independent of the T cell response.
journal_name
Virologyjournal_title
Virologyauthors
Horwitz MS,Ilic A,Fine C,Rodriguez E,Sarvetnick Ndoi
10.1016/s0042-6822(03)00462-8subject
Has Abstractpub_date
2003-09-30 00:00:00pages
510-20issue
2eissn
0042-6822issn
1096-0341pii
S0042682203004628journal_volume
314pub_type
杂志文章相关文献
VIROLOGY文献大全abstract::Alpha human papillomaviruses (HPVs) are among the most common sexually transmitted agents of which a subset causes cervical neoplasia and cancer in humans. Alpha-PVs have also been identified in non-human primates although few studies have systematically characterized such types. We cloned and characterized 10 distinc...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2009.07.012
更新日期:2009-10-25 00:00:00
abstract::Neutralizing antibodies (Nabs) are thought to play an important role in prevention and control of HIV-1 infection and should be targeted by an AIDS vaccine. It is critical to understand how HIV-1 induces Nabs by analyzing viral sequences in both tested viruses and sera. Neutralization susceptibility to antibodies in a...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2010.09.031
更新日期:2011-01-20 00:00:00
abstract::Coat protein-protected fragments of alfalfa mosaic virus RNA (AlMV-RNA) and tobacco streak virus RNA (TSV-RNA), which were isolated as described [D. Zuidema, M. F. A. Bierhuizen, B. J. C. Cornelissen, J. F. Bol, and E. M. J. Jaspars (1983)Virology, 125, 361-369], were tested for their ability to rebind AlMV coat prote...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(84)90165-x
更新日期:1984-07-30 00:00:00
abstract::Gene transfer into human hematopoietic stem cells using Ad5 is inefficient due to lack of the primary receptor CAR and the secondary receptors alphavbeta3 integrin and alphavbeta5 integrin, and due to the high seroprevalence of Ad5 antibodies in most adults, resulting in diminished gene transduction. In the present st...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2004.07.018
更新日期:2004-10-25 00:00:00
abstract::Human infections with highly pathogenic H5N1 avian influenza viruses continue to occur in many parts of the world and pose a considerable public health threat. With the use of animal models, the identification of virulence determinants has been instrumental in improving our understanding of how these viruses cause sev...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.02.005
更新日期:2011-05-10 00:00:00
abstract::Major efforts have been put forth for the development of effective rotavirus vaccines including transgenic plant vaccines. Previous studies have reported that rotavirus VP7 maintains its neutralizing immunity when it is transformed into the potato genome. The present study was aimed at investigating the hereditary sta...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2006.07.045
更新日期:2006-12-05 00:00:00
abstract::Mouse hepatitis virus (MHV) JHMV and its soluble receptor-resistant (srr) mutants, srr7, srr11, and srr18, grew and induced syncytia equally well in BHK-R1 cells expressing the MHVR1 receptor derived from MHV-susceptible BALB/c mice. In contrast, srr growth and syncytia formations were drastically reduced relative to ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2000.0409
更新日期:2000-07-20 00:00:00
abstract::Alpacas develop diminished disease following bovine viral diarrhea virus (BVDV) infection compared to cattle. We hypothesized that alpaca and bovine cells have differential permissiveness and responses to BVDV infection. To characterize alpaca testicular (AT) and bovine turbinate (BT) cells BVDV infection permissivene...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.02.006
更新日期:2011-04-25 00:00:00
abstract::Recently, cases of severe respiratory illness in military and civilian populations have been associated with a new genomic variant of adenovirus (Ad) serotype 14, designated Ad14a. Compared to the Ad14 reference strain (de Wit), this new virus had a deletion of two amino acid residues in the fiber protein knob. Here w...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2009.02.034
更新日期:2009-05-10 00:00:00
abstract::The circular single-stranded viral DNA (ssDNA) of filamentous phage is oriented in the virus with a hairpin forming sequence called mos at the leading end of the virion-the end that emerges from the cell first. In the experiments that originally defined mos it was also found to enhance virion production 100-fold, thou...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(88)90066-9
更新日期:1988-11-01 00:00:00
abstract::A quantitative analysis of Epstein-Barr virus (EBV)-induced early antigen (EA) and viral capsid antigen (VCA) syntheses was carried out in Raji cells superinfected with purified, concentrated P3HR-1 EBV. When the cells were exposed to the virus and assessed by immunofluorescence and immunoprecipitation, EA induction o...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(83)90276-3
更新日期:1983-07-30 00:00:00
abstract::Human cytomegalovirus (HCMV) lytic DNA replication is initiated at the cis-acting oriLyt region and requires six core replication proteins along with UL84 and IE2. Although UL84 is thought to be the replication initiator protein, little is known about its interaction with oriLyt. We have now performed chromatin immuno...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2009.06.035
更新日期:2009-09-15 00:00:00
abstract::Genotype VI-paramyxovirus (GVI-PMV1) is a major cause of epidemic Newcastle-like disease in Columbiformes. This genotype of avian paramyxovirus type 1 has diversified rapidly since its introduction into the US in 1982 resulting in two extant lineages, which have different population growth properties. Although some GV...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.06.007
更新日期:2014-08-01 00:00:00
abstract::The primary cell types that sustain polyomavirus (Py) replication following intranasal infection as well as the nature of the host cellular response to Py were unknown. As this is an essential and specific site for virus entry, it seems likely that viral gene function must be adapted to these mucosal tissues. Using im...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1999.0030
更新日期:2000-01-05 00:00:00
abstract::Insertion of nucleotide sequences encoding "tags" that can be expressed in specific viral proteins during an infection is a useful strategy for purifying viral proteins and their functional complexes from infected cells and/or for visualizing the dynamics of their subcellular location over time. To identify regions in...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2010.09.028
更新日期:2011-01-05 00:00:00
abstract::We characterized three subsets of NK cells in blood, and two subsets in mucosal tissues. SIVmac251 infection increased total and CD16(+) NK cells in the blood. In the rectum, we observed a significant increase in total and NKG2A(+) NK cells during SIV infection. In contrast, the NKp44(+) subset significantly depleted ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.12.003
更新日期:2014-02-01 00:00:00
abstract::Rabies continues to poses serious threats to the public health in many countries. The development of novel inexpensive, safe and effective vaccines has become a high priority for rabies control worldwide. We previously generated a novel recombinant rabies vaccine by cloning rabies virus glycoprotein into a chimpanzee ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.07.022
更新日期:2019-10-01 00:00:00
abstract::Multiple RNA species (ASV(1-5)) ranging in size from about 61,000 to 185,000 daltons have been detected in association with sunblotch disease of avocado. The predominant species, ASV(5), with a molecular weight of 61,000 accumulates to concentration approaching 5 S RNA. All RNA species are detected in extracts from sy...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(80)90370-0
更新日期:1980-07-15 00:00:00
abstract::Frog virus 3 (FV3) is the type species member of the genus Ranavirus (family Iridoviridae). To better understand the molecular mechanisms involved in the replication of FV3, including transcription of its highly methylated DNA genome, we have determined the complete nucleotide sequence of the FV3 genome. The FV3 genom...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2004.02.019
更新日期:2004-05-20 00:00:00
abstract::Toscana (TOS) virus stocks strongly interfering with standard virus replication were obtained by sequential passages of virus in suckling mouse brain. Characterization of viral RNAs in these stocks showed the presence of a heterogeneous population of defective RNA molecules derived from the L genomic segment, in both ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1998.9195
更新日期:1998-06-20 00:00:00
abstract::Multiple RNA species which hybridize to a cloned cDNA probe of the turnip crinkle virus satellite RNA (S-TCV) are found both in virions and in plants infected with virus particles containing S-TCV. At least six of these RNAs appear to be multimeric forms of the satellite RNA based on their migration in denaturing gels...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(84)90273-3
更新日期:1984-04-15 00:00:00
abstract::The RNA dependent RNA polymerase of Sendai virus consists of a complex of the large (L) and phosphoprotein (P) subunits where L is thought to be responsible for all the catalytic activities necessary for viral RNA synthesis. We previously showed that the L protein forms an oligomer [Smallwood, S., Cevik, B., Moyer, S....
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2007.01.032
更新日期:2007-06-20 00:00:00
abstract::Of five globally important VP7 (G) serotypes (G1-4 and 9) of group A rotaviruses (the single most important etiologic agents of infantile diarrhea worldwide), G9 continues to attract considerable attention because of its unique natural history. Serotype G9 rotavirus was isolated from a child with diarrhea first in the...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2004.11.006
更新日期:2005-02-05 00:00:00
abstract::Sensitivity of a library of rat cells transformed in vitro with viable recombinant adenoviruses to natural killer (NK) cells and allogeneic cytotoxic T cells has been studied and correlated with their oncogenic potential in syngeneic rats. All cell lines transformed with the sub370-12E1AB virus (containing E1A and E1B...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(85)90143-6
更新日期:1985-12-01 00:00:00
abstract::CD8(+) T-lymphocytes from HIV-1 infected individuals express unidentified factors that suppress viral replication by inhibiting HIV-1 gene expression. We examined the role of epigenetics in modulating the HIV-1 suppressive factors expressed by primary CD8(+) T cells from subjects naturally controlling virus replicatio...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2010.06.001
更新日期:2010-09-15 00:00:00
abstract::Previous work (C.F. Spiropoulou and S.T. Nichol, 1993, J. Virol. 67, 3103-3110) has demonstrated the existence in cells infected with the New Jersey serotype of vesicular stomatitis virus (VSV) of two small carboxy-coterminal proteins encoded by the P mRNA. These proteins have been named C' and C. We are interested in...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1996.0202
更新日期:1996-04-15 00:00:00
abstract::To elucidate the mechanism of formation of cowpea mosaic virus (CPMV) particles, RNA-2-encoded precursor proteins were expressed in Spodoptera frugiperda cells. Processing of the 105K and 95K polyproteins in trans to give the mature Large (L) and Small (S) coat proteins required both the 32K proteinase cofactor and th...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2009.08.023
更新日期:2009-10-25 00:00:00
abstract::The effect of murine cytomegalovirus (MCMV) infection on interleukin 1 (IL-1) secretion was assessed using the macrophage cell lines P388D1 and J774A.1. The former proved to be nonpermissive for MCMV in that infectious virus and viral immediate early protein (pp89) were not expressed in these cells. MCMV infection of ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(90)90342-o
更新日期:1990-10-01 00:00:00
abstract::The sequence of the 5'-end of the genome of dengue 2 (Jamaica genotype) virus has been previously reported (V. Deubel, R. M. Kinney, and D. W. Trent, 1986, Virology 155, 365-377). We have now cloned and sequenced the remaining 75% of the genomic RNA that encodes the nonstructural proteins. The complete genome is 10,72...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(88)90677-0
更新日期:1988-07-01 00:00:00
abstract::The nucleotide sequence of the env gene of a previously described human provirus (ERV3) has been determined beginning near the 3'-end of the pol gene and continuing through the 3'-LTR. Analysis of the nucleotide sequence revealed the presence of a long open reading frame of 1944 nucleotides that is capable of encoding...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(85)90147-3
更新日期:1985-12-01 00:00:00