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Antiretroviral therapy partly reverses the systemic and mucosal distribution of NK cell subsets that is altered by SIVmac₂₅₁ infection of macaques.

Abstract：

:We characterized three subsets of NK cells in blood, and two subsets in mucosal tissues. SIVmac251 infection increased total and CD16(+) NK cells in the blood. In the rectum, we observed a significant increase in total and NKG2A(+) NK cells during SIV infection. In contrast, the NKp44(+) subset significantly depleted in acute infection and continued to decline in frequency during chronic phase. During SIV infection, blood CD16 and mucosal NKG2A(+) subsets had increased cytotoxic potential. Intriguingly, the NKp44(+) NK cell subtype that likely mediates mucosal homeostasis via the production of cytokines, acquired cytotoxicity. Antiretroviral therapy significantly increased the frequency of mucosal NKG2A(+) NK cells and peripheral CD16(+) NK cells. However, it failed to restore the normal frequency of NKp44(+) NK cells in the rectum. Thus, SIVmac251 infection causes changes in the distribution and function of NK cells and antiretroviral therapy during chronic infection only partially restores NK homeostasis and function.

journal_name

Virology

journal_title

Virology

authors

Liyanage NP,Gordon SN,Doster MN,Pegu P,Vaccari M,Shukur N,Schifanella L,Pise-Masison CA,Lipinska D,Grubczak K,Moniuszko M,Franchini G

doi

10.1016/j.virol.2013.12.003

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

359-68

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(13)00666-1

journal_volume

450-451

pub_type

杂志文章

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