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Mouse xenotropic viruses can inhibit cell transformation.

Abstract：

:Mammalian type C retroviruses can be detected by their induction of foci of cell transformation in S+I - cells. We have noted that certain subtypes of the mouse xenotropic type C retrovirus (MuLV) inhibit this cell alteration. This inhibition, associated with intact virions, is irreversible and gives the infected cells a phenotype of uninfected cells. In comparison to the transformed cells, the inhibited cultures showed primarily a decrease in murine sarcoma virus (MSV) progeny production concomitant with a reduction in the MSV mos RNA expression. No difference in beta-actin RNA production was observed between the inhibited and transformed cultures. This selective effect of mouse xenotropic MuLV on MSV and mos RNA production in these cells focuses attention on the mechanism of transformation in this system.

journal_name

Virology

journal_title

Virology

authors

Hoffman AD,Levy JA

doi

10.1016/0042-6822(87)90044-4

subject

Has Abstract

pub_date

1987-09-01 00:00:00

pages

60-5

issue

1

eissn

0042-6822

issn

1096-0341

journal_volume

160

pub_type

杂志文章

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