Abstract:
:Respiratory syncytial virus is a major cause of bronchiolitis in infants and pneumonia virus of mice (PVM) causes similar disease in mice. The impact of PVM infection in BALB/c and C57BL/6 neonates, and upon re-infection as elderly mice, was compared. As previously shown for adult mice, PVM caused more disease in BALB/c than in C57BL/6 neonates. After PVM-15 infection BALB/c neonates showed higher production of inflammatory mediators, more influx of plasmacytoid dendritic cells and higher IFN-α expression, and more IgA in the lungs than C57BL/6 neonates. After re-infection as elderly, BALB/c mice developed virus neutralizing antibodies in serum and lung, and were protected from clinical disease, whereas C57BL/6 mice did not develop an anamnestic response and were not protected. These results suggest that an effective local innate response, as well as priming of mucosal adaptive responses in neonates after PVM-15 infection is correlated to decreased susceptibility and protection upon re-infection.
journal_name
Virologyjournal_title
Virologyauthors
Shrivastava P,Atanley E,Sarkar I,Watkiss E,Gomis S,van Drunen Littel-van den Hurk Sdoi
10.1016/j.virol.2015.07.019subject
Has Abstractpub_date
2015-11-01 00:00:00pages
233-43eissn
0042-6822issn
1096-0341pii
S0042-6822(15)00338-4journal_volume
485pub_type
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