Abstract:
:Section of the sciatic nerve during the period of herpes simplex virus (HSV) latent infection was performed to evaluate residual latency in mouse dorsal root ganglion. In control mice without sciatic neurectomy, latency was present in 90-100%, while in those which underwent a neurectomy procedure, latent infection was surprisingly decreased to 28-50%. To investigate the hypothesis that the decrease of latency resulted from HSV reactivation and replication (with subsequent neuron destruction), groups of mice were treated with acyclovir to inhibit HSV reactivation, after having undergone a neurectomy procedure. Acyclovir treatment largely prevented the neurectomy-related elimination of latency and supported the hypothesized mechanism.
journal_name
Virologyjournal_title
Virologyauthors
Tenser RB,Edris WA,Hay KAdoi
10.1016/0042-6822(88)90085-2subject
Has Abstractpub_date
1988-11-01 00:00:00pages
302-5issue
1eissn
0042-6822issn
1096-0341journal_volume
167pub_type
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