A transcriptional map of the bacteriophage SP01 genome: II. The major early transcription units.

abstract：:Viruses exploit phosphorylation of both viral and host proteins to support viral replication. In this study, we demonstrate that porcine reproductive and respiratory syndrome virus replicase nsp2, and two nsp2-related -2/-1 frameshifting products, nsp2TF and nsp2N, are hyper-phosphorylated. By mapping phosphorylation ...

journal_title：Virology

authors： Shang P,Yuan F,Misra S,Li Y,Fang Y

更新日期：2020-04-01 00:00:00

abstract：:The Autographa californica multiple nucleopolyhedrovirus (AcMNPV) occlusion-derived virus (ODV) envelope protein ODV-E56 is essential for oral infection of larvae of Heliothis virescens. Bioassays with recombinant clones of AcMNPV lacking a functional odv-e56 gene showed that ODV-E56 was required for infectivity of bo...

journal_title：Virology

authors： Sparks WO,Harrison RL,Bonning BC

更新日期：2011-01-05 00:00:00

abstract：:Binding of simian virus 40 (SV40) large T antigen to human and calf thymus topoisomerase I (topo I) was readily detected by using modified enzyme-linked immunosorbent assays and immunoblots. In addition to WT T antigen, binding could also be readily demonstrated with T antigen fragments from the amino-terminal region ...

journal_title：Virology

authors： Simmons DT,Melendy T,Usher D,Stillman B

更新日期：1996-08-15 00:00:00

abstract：:Virulence markers to distinguish high from low virulence bovine viral diarrhea virus genotype 2 isolates have not been previously reported. The objective of this study was to identify virulence markers by evaluating the primary and secondary structures of the 5'-untranslated region of low and high virulence bovine vir...

journal_title：Virology

authors： Topliff CL,Kelling CL

更新日期：1998-10-10 00:00:00

abstract：:The location of nucleotide sequences important in determining the extent of cowpea mosaic virus M-RNA accumulation in cowpea protoplasts has been analyzed by deletion mutagenesis of full-length cDNA clones from which infectious transcripts can be produced in vitro. The results suggest that cis-acting sequences which d...

journal_title：Virology

authors： Rohll JB,Holness CL,Lomonossoff GP,Maule AJ

更新日期：1993-04-01 00:00:00

abstract：:Transient expression studies using a Nicotiana benthamiana suspension cell-derived protoplast system have identified a minimal sequence that is necessary and sufficient for activation of the tomato golden mosaic virus coat protein (CP) promoter by the viral TrAP protein (also called AL2). The sequence has a bipartite ...

journal_title：Virology

authors： Sunter G,Bisaro DM

更新日期：2003-01-20 00:00:00

abstract：:We report the isolation and characterization of HEp-2c cell clones obtained after two successive persistent poliovirus (PV) infections. Once cured, some of the cell clones displayed selective permissivity toward the wild-type Mahoney strain and partial resistance to particular mutants of this strain, including the Sab...

journal_title：Virology

authors： Calvez V,Pelletier I,Couderc T,Pavio-Guédo N,Blondel B,Colbère-Garapin F

更新日期：1995-10-01 00:00:00

abstract：:Nonspecific anti-inflammatory drugs have been purported to reduce the burden of severe influenza disease. We demonstrate that, unlike oseltamivir administration, simvastatin administration did not reduce morbidity, mortality, or viral load of mice infected with H1N1 or H5N1 viruses. No added benefit to the efficacy of...

journal_title：Virology

authors： Belser JA,Szretter KJ,Katz JM,Tumpey TM

更新日期：2013-04-25 00:00:00

abstract：:Characterization of the regions of human papillomaviruses (HPVs) that elicit neutralizing immune responses supports studies on viral infectivity and provides insight for the development and evaluation of prophylactic vaccines. HPV11 is a major etiologic agent of genital warts and a likely vaccine candidate. A conforma...

journal_title：Virology

authors： Ludmerer SW,McClements WL,Wang XM,Ling JC,Jansen KU,Christensen ND

更新日期：2000-01-20 00:00:00

abstract：:The complete RNA sequence of the hepatitis delta virus (HDV) obtained from the Nauru Island in the Pacific was determined by cDNA cloning and amplification by polymerase chain reaction (PCR). The sequence showed 14-17% divergence from the two known HDV RNA sequences. There are three highly conserved domains: the regio...

journal_title：Virology

authors： Chao YC,Chang MF,Gust I,Lai MM

更新日期：1990-10-01 00:00:00

abstract：:Tumor-inducing viruses like simian virus 40 or the human adenovirus produce oncoproteins which interfere with the cellular retinoblastoma (Rb) tumor-suppressor protein to create an appropriate molecular environment in the nucleus for viral transcription and replication. Such a strategy has been considered to be restri...

journal_title：Virology

authors： Collin S,Fernández-Lobato M,Gooding PS,Mullineaux PM,Fenoll C

更新日期：1996-05-01 00:00:00

abstract：:Pseudorecombinants produced by exchanging genome components (DNAs A and B) of the geminiviruses African cassava mosaic virus (ACMV) and Indian cassava mosaic virus (ICMV), ACMV, and tomato golden mosaic virus (TGMV), and TGMV and abutilon mosaic virus (AbMV) are not infectious in their common host Nicotiana benthamian...

journal_title：Virology

authors： Frischmuth T,Roberts S,von Arnim A,Stanley J

更新日期：1993-10-01 00:00:00

abstract：:The 121,752-bp genome sequence of bacteriophage T5 was determined; the linear, double-stranded DNA is nicked in one of the strands and has large direct terminal repeats of 10,139 bp (8.3%) at both ends. The genome structure is consistently arranged according to its lytic life cycle. Of the 168 potential open reading f...

journal_title：Virology

authors： Wang J,Jiang Y,Vincent M,Sun Y,Yu H,Wang J,Bao Q,Kong H,Hu S

更新日期：2005-02-05 00:00:00

abstract：:Torque Teno Virus (TTV) has been assigned to the floating genus Anellovirus. TTV ssDNA genomes have a size of 3.6 to 3.8 kb and display up to 30% nucleotide diversity. The pathogenic potential of TTV is under investigation. To address a putative link of pathogenicity with the observed sequence variations, the transcri...

journal_title：Virology

authors： Mueller B,Maerz A,Doberstein K,Finsterbusch T,Mankertz A

更新日期：2008-11-10 00:00:00

abstract：:Pseudorabies virus (PRV) China reference strain Ea is genetically closely related to newly emerged variants; however, there is limited information about PRV Ea. Here, we compared PRV Ea with new variant strains by growth kinetics, genome sequencing, and protein expression analysis. Growth analysis showed that strain E...

journal_title：Virology

authors： Wang X,Wu CX,Song XR,Chen HC,Liu ZF

更新日期：2017-06-01 00:00:00

abstract：:Maturation of T4 can proceed in the presence of 5-methyltryptophan or puromycin. Puromycin inhibits phage protein synthesis within a few seconds, thus limiting the amount of phage precursor material available for maturation. After the arrest of protein synthesis, maturation continues unabated until the limiting protei...

journal_title：Virology

authors： Piechowski MM,Susman M

更新日期：1966-03-01 00:00:00

abstract：:Influenza A H1N2 viruses, which emerged during 2001, are genetic reassortants between H1N1 and H3N2 subtype viruses which have cocirculated in the human population since 1977. They possess a H1 hemagglutinin antigenically and genetically similar to contemporary A/New Caledonia/20/99 (H1N1)-like viruses and seven genes...

journal_title：Virology

authors： Gregory V,Bennett M,Orkhan MH,Al Hajjar S,Varsano N,Mendelson E,Zambon M,Ellis J,Hay A,Lin YP

更新日期：2002-08-15 00:00:00

abstract：:The papillomavirus (PV) E2 protein activates transcription and replication by recruiting cellular proteins and the E1 DNA helicase to their binding sites in the viral genome. We recently demonstrated that phosphorylation of tyrosine 102 in the bovine papillomavirus (BPV-1) E2 protein restricts these activities and tha...

journal_title：Virology

authors： DeSmet M,Kanginakudru S,Jose L,Xie F,Gilson T,Androphy EJ

更新日期：2018-08-01 00:00:00

abstract：:cDNAs of beet necrotic yellow vein virus RNAs 3 and 4 could be rendered biologically active when they were placed under the control of the cauliflower mosaic virus 35S promoter and polyadenylation signal. Although the 35S in vivo transcripts should have contained up to forty 5' and several hundred 3' nonviral nucleoti...

journal_title：Virology

authors： Commandeur U,Jarausch W,Li Y,Koenig R,Burgermeister W

更新日期：1991-11-01 00:00:00

abstract：:The V protein of Sendai virus (SeV) is nonessential for virus replication in cell culture but indispensable for viral pathogenicity in mice. At the C terminus of the V protein, there are amino acid residues conserved among the members of the Paramyxovinae subfamily that are clustered in three regions: region I, just d...

journal_title：Virology

authors： Fukuhara N,Huang C,Kiyotani K,Yoshida T,Sakaguchi T

更新日期：2002-08-01 00:00:00

abstract：:The Rta (R transactivator) protein plays an essential role in the Epstein-Barr viral (EBV) lytic cascade. Rta activates viral gene expression by several mechanisms including direct and indirect binding to target viral promoters, synergy with EBV ZEBRA protein, and stimulation of cellular signaling pathways. We previou...

journal_title：Virology

authors： Chen LW,Raghavan V,Chang PJ,Shedd D,Heston L,Delecluse HJ,Miller G

更新日期：2009-04-10 00:00:00

abstract：:Mutational analyses were carried out to investigate whether the nuclear inclusion protein a (NIa) C-terminal amino acids of turnip mosaic potyvirus play any roles in the cis-cleavage between NIa and NIb. The processing rate of the NIa-NIb junction sequence was decreased significantly by either V240D or Q243A mutation ...

journal_title：Virology

authors： Kim DH,Han JS,Lew J,Kim SS,Kang BH,Hwang DC,Jang DS,Kim W,Song BD,Choi KY

更新日期：1998-02-01 00:00:00

abstract：:The Epstein-Barr virus (EBV) nuclear antigen EBNA-1 is essential for viral genome maintenance in vitro and may be the only EBV protein expressed by the majority of latently infected cells in vivo. EBNA-1 may therefore be critical to the evasion of host immunity which allows persistent infection. EBNA-1 includes a poly...

journal_title：Virology

authors： Wrightham MN,Stewart JP,Janjua NJ,Pepper SD,Sample C,Rooney CM,Arrand JR

更新日期：1995-04-20 00:00:00

abstract：:The splice acceptor site of pX gene of HTLV-I has been determined to be at base position 7301 using S1 nuclease protection analysis. This splice acceptor site is used in all HTLV-I immortalized T-cell clones studied despite variation in the abundance levels of pX mRNA. Our results confirmed the proposal by Haseltine e...

journal_title：Virology

authors： Okamoto T,Josephs SF,Kawanishi M,Wong-Staal F

更新日期：1985-06-01 00:00:00

abstract：:Human parainfluenza virus type 2 phosphoprotein (P) is an essential component of viral polymerase. The P gene encodes both P and accessory V proteins by a specific gene editing mechanism. Therefore, the N-terminal 164 amino acids of P protein are common to V protein. Interestingly, while P protein is located in the cy...

journal_title：Virology

authors： Ohtsuka J,Matsumoto Y,Ohta K,Fukumura M,Tsurudome M,Nosaka T,Nishio M

更新日期：2019-02-01 00:00:00

abstract：:Central African tropical forests are home to several species of non-human primates (NHPs), infected by Simian Immunodeficiency Virus (SIV). It is well-known that HIV-1 epidemic is due to cross-transmission and adaptation of SIV to humans. The main goal of this work was to investigate if a NHP bite is a risk factor for...

journal_title：Virology

authors： Filippone C,de Oliveira F,Betsem E,Schaeffer L,Fontanet A,Lemée V,Gessain A,Plantier JC

更新日期：2017-03-01 00:00:00

abstract：:In a previous study on the replication of Kunjin virus using immunoelectron microscopy (E. G. Westaway, J. M. Mackenzie, M. T. Kenney, M. K. Jones, and A. A. Khromykh, 1997, J. Virol. 71, 6650-6661), NS1 and NS3 were found associated with double-stranded RNA (dsRNA) within vesicle packets (VP) in infected Vero cells, ...

journal_title：Virology

authors： Mackenzie JM,Khromykh AA,Jones MK,Westaway EG

更新日期：1998-06-05 00:00:00

abstract：:The preS(21-47) sequence of the hepatitis B virus (HBV) envelope protein is involved in binding of the virus to cell receptors. A protein similarity search revealed a partial homology between this sequence and a segment of the human immunoglobulin A (IgA) heavy chain constant region, suggesting that the cell attachmen...

journal_title：Virology

authors： Neurath AR,Strick N

更新日期：1990-10-01 00:00:00

abstract：:Polyomavirus (PyV) infection induces protective T-cell-independent (TI) IgM and IgG responses in T-cell-deficient (TCR beta x delta-/-) mice. In this study, we show that PyV is a TI -2 antigen: B cells with a mutated Bruton's tyrosine kinase (Xid mutants) do not respond to PyV with antibody secretion in the absence of...

journal_title：Virology

authors： Szomolanyi-Tsuda E,Brien JD,Dorgan JE,Garcea RL,Woodland RT,Welsh RM

更新日期：2001-02-15 00:00:00

abstract：:Replication of hepatitis B virus (HBV) proceeds by reverse transcription of an RNA intermediate inside the viral nucleocapsid formed by the core protein. This protein contains four Cys residues which occur at equivalent positions in the core proteins of all known mammalian hepadnaviruses, suggesting that they might be...

journal_title：Virology

authors： Nassal M

更新日期：1992-09-01 00:00:00