Differences in signal peptide processing between GP3 glycoproteins of Arteriviridae.

abstract：:To better understand the origin of human T-cell leukemia virus type l (HTLV-l) in South America, we conducted a phylogenetic study on 27 new HTLV-ls in Brazil. These were obtained from Brazilians of various ethnic origins, such as Japanese immigrants, whites, blacks and mulattos. We amplified and sequenced proviral DN...

journal_title：Virology

authors： Yamashita M,Veronesi R,Menna-Barreto M,Harrington WJ Jr,Sampio C,Brites C,Badaro R,Andrade-Filho AS,Okhura S,Igarashi T,Takehisa J,Miura T,Chamone D,Bianchini O,Jardim C,Sonoda S,Hayami M

更新日期：1999-08-15 00:00:00

abstract：:A crucial step in the arenavirus life cycle is the proteolytic processing of the viral envelope glycoprotein precursor (GPC) by the cellular proprotein convertase (PC) subtilisin kexin isozyme-1 (SKI-1)/site-1 protease (S1P). Here we conducted a systematic and quantitative analysis of SKI-1/S1P processing of peptides ...

journal_title：Virology

authors： Pasquato A,Burri DJ,Traba EG,Hanna-El-Daher L,Seidah NG,Kunz S

更新日期：2011-08-15 00:00:00

abstract：:The interferon sensitivity of the expression of an influenza-virus hemagglutinin (HA) gene cloned into the thymidine kinase (TK) gene of vaccinia virus was studied in chick embryo fibroblasts (CEF) and Madin-Darby bovine kidney (MDBK) cells. In CEF, the expression of the HA gene is inhibited by pretreatment of cells w...

journal_title：Virology

authors： Degen HJ,Blum D,Grün J,Jungwirth C

更新日期：1992-05-01 00:00:00

abstract：:Transcriptionally targeted MLV-based ProCon vectors allow expression of the transduced gene in a promoter-specific manner by replacement of the viral U3 region with a heterologous promoter. In order to evaluate the effects of sequence elements present in ProCon vectors on transgene expression (enhanced green fluoresce...

journal_title：Virology

authors： Hlavaty J,Portsmouth D,Stracke A,Salmons B,Günzburg WH,Renner M

更新日期：2004-12-05 00:00:00

abstract：:Primate lentiviruses are composed of several distinct lineages, including human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus SIVagm. HIV-1 and HIV-2 have significant differences in the mechanisms of viral RNA encapsidation. Therefore, the RNA packaging mechanisms of SIVagm cannot be ...

journal_title：Virology

authors： Fu W,Prasad VV,Chen J,Nikolaitchik O,Hu WS

更新日期：2007-06-20 00:00:00

abstract：:Hematopoietic malignant cells of various types were isolated from ICFW mice inoculated as newborn or adult with F-MuLV and grafted into recipient mice. After repeated in vivo cell transplants, several recombinant polytropic viruses (also termed MCF or dualtropic viruses) were isolated from tumors by limiting dilution....

journal_title：Virology

authors： Della-Valle V,Wendling F,Sitbon M,Varlet P,Mathieu-Mahul D,Larsen CJ

更新日期：1990-10-01 00:00:00

abstract：:Two HLA-A*02-restricted epitopes have been identified within the VP1 polypeptide of a human polyomavirus, BK virus, which is associated with polyomavirus-associated nephropathy in kidney transplant patients. Immunization of transgenic mice with recombinant modified vaccinia Ankara expressing BKV VP1 (rMVA-BKV VP1) eli...

journal_title：Virology

authors： Sharma MC,Zhou W,Martinez J,Krymskaya L,Srivastava T,Haq W,Diamond DJ,Lacey SF

更新日期：2006-06-20 00:00:00

abstract：:Two minor proteins with molecular masses of 8.5 and 15.5 kDa were identified in feline calicivirus (FCV) virions. Direct sequence analysis showed that the N-terminal sequence of the 8.5-kDa protein was identical to that of the predicted protein encoded by open reading frame 3 (ORF3) of the FCV genome. The N-terminal s...

journal_title：Virology

authors： Sosnovtsev SV,Green KY

更新日期：2000-11-10 00:00:00

abstract：:Rat 3Y1 cells were infected by AKR virus through microinjection of molecularly cloned proviral DNA. Based on a strong immunofluorescence using anti-p30 as an antiserum a cell clone (RESA-2) was selected that had a high expression of viral antigens. Subsequent restriction analysis of its DNA revealed that the RESA-2 cl...

journal_title：Virology

authors： van der Hoorn FA,Saris CJ,Bloemers HP

更新日期：1983-01-30 00:00:00

abstract：:A central, yet unresolved issue in the pathogenesis of HIV disease is the mechanism of antibody perturbation. In this study, HIV-specific memory B-cells were quantified in groups of infected subjects and compared with memory responses to other antigens and antibody titers. HIV-specific memory B-cell responses were vig...

journal_title：Virology

authors： Bussmann BM,Reiche S,Bieniek B,Krznaric I,Ackermann F,Jassoy C

更新日期：2010-02-05 00:00:00

abstract：:Persistent infection with the Edmonston strain of measles virus (MV) has been established in IC-21 cells, an immortalized murine macrophage cell line. Persistence was established immediately without syncytia formation or cytopathic effects. MV was expressed in the majority of the cells as evidenced by immunofluorescen...

journal_title：Virology

authors： Goldman MB,Buckthal DJ,Picciotto S,O'Bryan TA,Goldman JN

更新日期：1995-02-20 00:00:00

abstract：:Several VV structural proteins are produced by the removal of amino-terminal peptides from their cognate precursors. In the experiments reported here, directed genetic approaches were used to investigate the possible role of these terminal peptides in protein processing. As a model system, the FLAG epitope-tagged P25K...

journal_title：Virology

authors： Lee P,Hruby DE

更新日期：1995-02-20 00:00:00

abstract：:Viroids are small, nontranslatable pathogenic RNAs that replicate autonomously and traffic systemically in their host plants. We have used in situ hybridization to analyze the trafficking pattern of Potato spindle tuber viroid (PSTVd) in tomato and Nicotiana benthamiana. When PSTVd was inoculated onto the stem of a pl...

journal_title：Virology

authors： Zhu Y,Green L,Woo YM,Owens R,Ding B

更新日期：2001-01-05 00:00:00

abstract：:As porcine endogenous retroviruses (PERV) productively infect human cells in vitro, they pose a serious risk in xenotransplantation and xenogeneic cell therapies. We have analyzed the prevalence of six well-characterized full-length PERV, five of them being replication-competent and four of them being chromosomally as...

journal_title：Virology

authors： Niebert M,Tönjes RR

更新日期：2003-09-01 00:00:00

abstract：:The single-cell ELISPOT assay was used to determine the frequency and isotype commitment of virus-specific antibody-forming cells (AFC) at different anatomical locations following intranasal Sendai virus infection of C57BL/6 and 129/Sv mice. AFC responses in the mediastinal and cervical lymph nodes showed sharp increa...

journal_title：Virology

authors： Sangster M,Hyland L,Sealy R,Coleclough C

更新日期：1995-02-20 00:00:00

abstract：:The measles virus (MV) phosphoprotein (P) and V proteins block the interferon (IFN) response by impeding phosphorylation of the signal transducer and activator of transcription 1 (STAT1) by the Janus kinase 1 (JAK1). We characterized how STAT1 mutants interact with P and JAK1 phosphorylation. Certain mutants of the li...

journal_title：Virology

authors： Devaux P,Priniski L,Cattaneo R

更新日期：2013-09-01 00:00:00

abstract：:Proviral sequences encoding defective HIV-1 regulatory genes have been detected previously in infected individuals; however, the role of these defective genomes in pathogenesis is unclear. The hypothesis that such replication-defective genomes might induce downregulation of the cellular receptor for HIV-1 (CD4) was te...

journal_title：Virology

authors： Little SJ,Riggs NL,Chowers MY,Fitch NJ,Richman DD,Spina CA,Guatelli JC

更新日期：1994-12-01 00:00:00

abstract：:Understanding the mechanism of HIV-1 latency is crucial to the viral reservoir eradication. Human cellular miRNAs can modulate HIV-1 expression by targeting of viral RNAs or host gene transcripts. To identify miRNAs modulating HIV-1 latency, we determined the miRNA expression profiles of HIV-1 latently infected and pr...

journal_title：Virology

authors： Wang P,Qu X,Zhou X,Shen Y,Ji H,Fu Z,Deng J,Lu P,Yu W,Lu H,Zhu H

更新日期：2015-12-01 00:00:00

abstract：:Hemagglutination is an established method but has not been used previously to determine the efficacy of virus binding to a specific cellular receptor. Here we have utilized CD46-expressing erythrocytes from a transgenic mouse to establish whether and to what extent the species B adenoviruses (Ads) as well as Ad37 and ...

journal_title：Virology

authors： Andersson EK,Mei YF,Wadell G

更新日期：2010-06-20 00:00:00

abstract：:Mannose binding lectin (MBL) is a collagenous C-type lectin, which plays an important role in innate immunity. It can bind to carbohydrates on the surface of a wide range of pathogens, including viruses. Here we studied the antiviral effect of recombinant chicken (rc)MBL against Infectious Bronchitis Virus (IBV), a hi...

journal_title：Virology

authors： Zhang W,Bouwman KM,van Beurden SJ,Ordonez SR,van Eijk M,Haagsman HP,Verheije MH,Veldhuizen EJA

更新日期：2017-09-01 00:00:00

abstract：:Proinflammatory cytokines and chemokines are often detected in brain tissue of patients with neurological diseases such as multiple sclerosis (MS), HIV-associated dementia (HAD) and Alzheimer's disease (AD). We have utilized a mouse model of retrovirus-induced neurological disease to examine how these proinflammatory ...

journal_title：Virology

authors： Peterson KE,Evans LH,Wehrly K,Chesebro B

更新日期：2006-10-10 00:00:00

abstract：:The details of intracellular transport pathways for glycosylated proteins remain incompletely described. We previously described a mutant Rous sarcoma virus envelope glycoprotein (gp), mu 26, with an altered membrane-spanning domain that was targeted to lysosomes after traversing the trans-Golgi. This mutant protein w...

journal_title：Virology

authors： Johnston PB,Dong JY,Hunter E

更新日期：1995-01-10 00:00:00

abstract：:The protein p10 that forms the connector of phage phi 29, has been produced in Escherichia coli harboring a plasmid that carried the gene coding for this protein. The connector protein is assembled in a 13.4-S oligomer that has an apparent molecular weight of 460,000, suggesting that it is a dodecamer. The purified ol...

journal_title：Virology

authors： Carrascosa JL,Carazo JM,Ibañez C,Santisteban A

更新日期：1985-03-01 00:00:00

abstract：:Activation of interferon regulatory factors (IRFs) 3 and 7 is essential for the induction of Type I interferons (IFN) and innate antiviral responses, and herpesviruses have evolved mechanisms to evade such responses. We previously reported that Epstein-Barr virus BZLF1, an immediate-early (IE) protein, inhibits the fu...

journal_title：Virology

authors： Bentz GL,Liu R,Hahn AM,Shackelford J,Pagano JS

更新日期：2010-06-20 00:00:00

abstract：:The pathogenesis of Venezuelan equine encephalitis virus (VEE) was examined in the mouse model using V3000, a virus derived from a molecular clone of the Trinidad donkey strain of VEE. These results were compared in parallel experiments with avirulent mutants of VEE derived by site-directed mutagenesis of the clone. A...

journal_title：Virology

authors： Grieder FB,Davis NL,Aronson JF,Charles PC,Sellon DC,Suzuki K,Johnston RE

更新日期：1995-02-01 00:00:00

abstract：:Segmented genomes of RNA viruses are thought to evolve and be maintained in analogy to sexual recombination and reassortment in eukaryotic systems. If reassortment among genomes is an important event in cucumoviral evolution, then such events should be detectable among extant viruses. In this study, phylogenetic analy...

journal_title：Virology

authors： White PS,Morales F,Roossinck MJ

更新日期：1995-02-20 00:00:00

abstract：:We examined nine dengue virus-specific human CD4+ CD8- cytotoxic T lymphocyte (CTL) clones for protein recognition, using recombinant vaccinia viruses which contain genes coding for dengue virus proteins. These clones were established from peripheral blood mononuclear cells of a donor previously immunized with a live-...

journal_title：Virology

authors： Green S,Kurane I,Pincus S,Paoletti E,Ennis FA

更新日期：1997-08-04 00:00:00

abstract：:Cellular activation plays an important role in retroviral replication. Previously, we have shown that CD4(+)CD25(+) T cells by the virtue of their partially activated phenotype represent ideal candidates for a productive feline immunodeficiency virus (FIV) infection. In the present study, we extended our previous obse...

journal_title：Virology

authors： Joshi A,Garg H,Tompkins MB,Tompkins WA

更新日期：2005-05-10 00:00:00

abstract：:To celebrate the sixtieth anniversary of Virology a survey is made of the plant viruses, virologists and their institutions, and tools and technology described in the first decade of plant virus publications in Virology. This was a period when plant viruses increasingly became tools of discovery as epistemic objects a...

journal_title：Virology

authors： Scholthof KB

更新日期：2015-05-01 00:00:00

abstract：:The sequence of gene VI from figwort mosaic virus (FMV) clone x4 was determined and compared with that previously published for FMV clone DxS. Both clones originated from the same virus isolation, but the virus used to clone DxS was propagated extensively in a host of a different family prior to cloning whereas that u...

journal_title：Virology

authors： Sanger M,Daubert S,Goodman RM

更新日期：1991-06-01 00:00:00