Temperature-sensitive mutants in the vaccinia virus 4b virion structural protein assemble malformed, transcriptionally inactive intracellular mature virions.

abstract：:The Tat regulatory protein encoded by human immunodeficiency virus type 1 (HIV-1) induces high levels of transcription from the viral long terminal repeat (LTR) promoter element after interacting with a promoter proximal RNA target sequence. In the wild-type HIV-1 LTR, this activation is facilitated by the synergistic...

journal_title：Virology

authors： Madore SJ,Cullen BR

更新日期：1995-02-01 00:00:00

abstract：:It has been widely demonstrated that the human immunodeficiency virus type 1 (HIV-1) envelope, specifically the V3 loop of the gp120 spike, evolves to facilitate adaptation to different cellular populations within an infected host. Less energy has been directed at determining whether the viral promoter, designated the...

journal_title：Virology

authors： McAllister JJ,Phillips D,Millhouse S,Conner J,Hogan T,Ross HL,Wigdahl B

更新日期：2000-09-01 00:00:00

abstract：:Monoclonal antibodies have been produced and used to map the functional topography of the surface proteins of rhesus rotavirus (RRV) that mediate viral neutralization. Ten monoclonal antibodies directed to VP7 were studied in neutralization assays and competitive binding studies. A large neutralization domain with sev...

journal_title：Virology

authors： Shaw RD,Vo PT,Offit PA,Coulson BS,Greenberg HB

更新日期：1986-12-01 00:00:00

abstract：:Infection with many viruses results in the selective shutoff of host protein synthesis. A common target for virus interference with host protein synthesis is the cap-binding protein complex, eIF4F. The large subunit of the complex, eIF4G, is cleaved upon picornavirus (except cardiovirus) infection. Infection with aden...

journal_title：Virology

authors： Gingras AC,Sonenberg N

更新日期：1997-10-13 00:00:00

abstract：:We describe a novel virus, AFV1, of the hyperthermophilic archaeal genus Acidianus. Filamentous virions are covered with a lipid envelope and contain at least five different proteins with molecular masses in the range of 23-130 kDa and a 20.8-kb-long linear double-stranded DNA. The virus has been assigned to the famil...

journal_title：Virology

authors： Bettstetter M,Peng X,Garrett RA,Prangishvili D

更新日期：2003-10-10 00:00:00

abstract：:Very fast sedimenting DNA (VFS DNA) of T4 phage, which is formed by infection with a mutant in gene 49, was examined by electron microscopy after mild treatment with DNase I. It showed Y-shaped, branched strands in addition to linear strands. Each branch contained a single-stranded interruption about 60 nucleotides lo...

journal_title：Virology

authors： Minagawa T,Murakami A,Ryo Y,Yamagishi H

更新日期：1983-04-15 00:00:00

abstract：:Many viruses, including human immunodeficiency virus type 1 (HIV-1), induce apoptosis and are affected by cellular expression of antiapoptotic genes. We sought to examine the effect of antiapoptotic gene expression on HIV replication by transfecting the promyelomonocytic cell line U937 with the bcl-xl gene to obtain c...

journal_title：Virology

authors： Marshall WL,Datta R,Hanify K,Teng E,Finberg RW

更新日期：1999-03-30 00:00:00

abstract：:We investigated the effect of selection pressures on evolution of HIV-1 pol in 51 patients after switching to a new antiretroviral combination reverse transcriptase (RT) inhibitor therapy. Evolution of the protease (PR) and RT reading frames were analysed separately. Pairwise evolutionary distances (ED) were calculate...

journal_title：Virology

authors： Günthard HF,Leigh-Brown AJ,D'Aquila RT,Johnson VA,Kuritzkes DR,Richman DD,Wong JK

更新日期：1999-06-20 00:00:00

abstract：:Experiments with monoclonal antibodies raised against two laboratory strains of Sindbis virus, SB and SIN, suggested the existence of a strain-specific neutralizing antigenic site (E2-b) on the E2 glycoprotein. A comparison of monoclonal antibody binding patterns and E2 glycoprotein gene sequences of six laboratory st...

journal_title：Virology

authors： Davis NL,Pence DF,Meyer WJ,Schmaljohn AL,Johnston RE

更新日期：1987-11-01 00:00:00

abstract：:Reactivation of latent herpes simplex virus 2 (HSV-2) infections can be characterized by episodic recurrent genital lesions and/or viral shedding. We hypothesize that infected (HSV-2(pos)) asymptomatic individuals have acquired T cell responses to specific HSV-2 antigen(s) that may be an important factor in controllin...

journal_title：Virology

authors： Long D,Skoberne M,Gierahn TM,Larson S,Price JA,Clemens V,Baccari AE,Cohane KP,Garvie D,Siber GR,Flechtner JB

更新日期：2014-09-01 00:00:00

abstract：:To address the mechanisms of host-virus adaptation and pathogenesis of lentiviral infections, we compared the evolution of the same isolate of simian immunodeficiency virus (SIVsmm9) in two different situations: nonpathogenic infection of its natural host, the sooty mangabey, and AIDS-inducing infection of a new host,...

journal_title：Virology

authors： Courgnaud V,Saurin W,Villinger F,Sonigo P

更新日期：1998-07-20 00:00:00

abstract：:Nineteen independent temperature-sensitive (ts) mutants were isolated from SA11 following mutagenesis with proflavin or 5-azacytidine. Fourteen of the ts mutants fell into one or another of five mutant groups previously defined by recombination. Five of the ts mutants defined five recombination groups (F, G, H, I, and...

journal_title：Virology

authors： Ramig RF

更新日期：1983-10-30 00:00:00

abstract：:We have developed a sensitive assay for DNA replication in mammalian cells that enables us to detect replicated DNA fragments of human cytomegalovirus. A 1/100 portion of DNA extracted from 1000 microinjected cells was subjected to polymerase chain reaction after digestion with appropriate restriction enzymes to diffe...

journal_title：Virology

authors： Watanabe S,Yamaguchi N

更新日期：1993-01-01 00:00:00

abstract：:Unusual Plum pox virus (PPV) isolates (named Tat isolates) were discovered on sour cherry (Prunus cerasus) in Russia. They failed to be recognized by RT-PCR using commonly employed primers specific to the strains C or CR (the only ones that proved able to infect sour cherry) as well as to the strains M and W. Some of ...

journal_title：Virology

authors： Chirkov S,Ivanov P,Sheveleva A,Zakubanskiy A,Osipov G

更新日期：2017-02-01 00:00:00

abstract：:Purified preparations of the Helminthosporium victoriae 190S (Hv190S) virus contain two sedimenting components that differ in capsid structure. The slower sedimenting component (190S-1) contained p88 and p83 as the major capsid proteins; the faster component (190S-2) contained p88 and p78. Previous peptide-mapping stu...

journal_title：Virology

authors： Ghabrial SA,Havens WM

更新日期：1992-06-01 00:00:00

abstract：:Animal viruses profoundly modify the metabolism of lipids, the synthesis of new membranes, and membrane traffic. These alterations are related to the replication of viral genomes. Addition of oleic acid from the beginning of poliovirus infection inhibits the appearance of virus polypeptides at concentrations that do n...

journal_title：Virology

authors： Guinea R,Carrasco L

更新日期：1991-11-01 00:00:00

abstract：:The function of the 16-kDa protein encoded by tobacco rattle virus (TRV) RNA-1 was investigated by a mutational analysis of the 16-kDa protein gene. Transcripts of TRV RNA-1 produced from a full-length cDNA clone of TRV RNA-1 (SYM strain) remained infectious when the 16-kDa protein gene was disrupted by premature term...

journal_title：Virology

authors： Guilford PJ,Ziegler-Graff V,Baulcombe DC

更新日期：1991-06-01 00:00:00

abstract：:Strong evidence indicates that virions of mammalian reoviruses undergo proteolytic processing by acid-dependent cellular proteinases as an essential step in productive infection. Proteolytic processing takes the form of a series of cleavages of outer-capsid proteins final sigma3 and mu1/mu1C. Previous studies showed a...

journal_title：Virology

authors： Kothandaraman S,Hebert MC,Raines RT,Nibert ML

更新日期：1998-11-25 00:00:00

abstract：:Members of the genus Mastrevirus (family Geminiviridae) produce a complementary-sense (c-sense) transcription unit with the potential to encode two proteins, RepA and Rep. In the present work, we have studied the DNA-protein complexes formed by the Wheat dwarf virus (WDV) RepA protein within the WDV large intergenic r...

journal_title：Virology

authors： Missich R,Ramirez-Parra E,Gutierrez C

更新日期：2000-07-20 00:00:00

abstract：:Little is known about the molecular determinants causing and sustaining viral persistent infections at the cellular level. We found that Drosophila cells persistently infected (PI) with Flock House virus (FHV) invariably harbor defective viral RNAs, which are replicated by the FHV RNA-dependent RNA polymerase. Some de...

journal_title：Virology

authors： Jovel J,Schneemann A

更新日期：2011-10-10 00:00:00

abstract：:Infection with the Tucson strain of coxsackievirus B1 (CVB1T) causes the development of chronic inflammatory myopathy (CIM) and hind limb weakness in susceptible strains of mice. In this study, a panel of six plaque-purified viruses exhibiting either small or large plaque phenotypes was derived from parental CVB1T and...

journal_title：Virology

authors： Tam PE,Messner RP

更新日期：1997-06-23 00:00:00

abstract：:Callitrichid hepatitis (CH) is a highly fatal, rodent-borne zoonosis of New World primates (family Callitrichidae) caused by lymphocytic choriomeningitis virus (LCMV). It is unclear whether virulence in Callitrichidae is associated with specific genetic or phylogenetic markers of the virus as only a partial S RNA sequ...

journal_title：Virology

authors： Asper M,Hofmann P,Osmann C,Funk J,Metzger C,Bruns M,Kaup FJ,Schmitz H,Günther S

更新日期：2001-06-05 00:00:00

abstract：:Hepatitis B virus-infected patients frequently have viral particles with DNA derived from differently spliced RNA. Which factors influence the synthesis of these splice variants is unclear. We analysed the type of splice variants produced from different genotypes and determined whether they are secreted as efficiently...

journal_title：Virology

authors： Sommer G,van Bömmel F,Will H

更新日期：2000-06-05 00:00:00

abstract：:High Plains wheat mosaic virus (HPWMoV, genus Emaravirus; family Fimoviridae), transmitted by the wheat curl mite (Aceria tosichella Keifer), harbors a monocistronic octapartite single-stranded negative-sense RNA genome. In this study, putative proteins encoded by HPWMoV genomic RNAs 2-8 were screened for potential RN...

journal_title：Virology

authors： Gupta AK,Hein GL,Graybosch RA,Tatineni S

更新日期：2018-05-01 00:00:00

abstract：:The tail sheath protein of giant bacteriophage phiKZ Pseudomonas aeruginosa encoded by gene 29 was identified and its expression system was developed. Localization of the protein on the virion was confirmed by immunoelectron microscopy. Properties of gene product (gp) 29 were studied by electron microscopy, immunoblot...

journal_title：Virology

authors： Kurochkina LP,Aksyuk AA,Sachkova MY,Sykilinda NN,Mesyanzhinov VV

更新日期：2009-12-20 00:00:00

abstract：:Tandemers 2MG, 2MG3, 3MG and 4MG are derivatives of the potent anti-HIV-1 microbicide candidate griffithsin (GRFT). We compared these compounds anti-HIV-1 activity to GRFT using the viruses CAP206.08 and CAAN5342.A2 that have decreased sensitivity to this lectin. The 2MG and 2MG3 tandemers had similar activity to GRFT...

journal_title：Virology

authors： Alexandre K,Malatji K,Mulaudzi T

更新日期：2020-05-01 00:00:00

abstract：:The 2009 influenza pandemic originated from a swine-origin H1N1 virus, which, although less pathogenic than anticipated, may acquire additional virulence-associated mutations in the future. To estimate the potential risk, we sequentially passaged the isolate A/Hamburg/04/2009 in A549 human lung epithelial cells. After...

journal_title：Virology

authors： Wörmann X,Lesch M,Welke RW,Okonechnikov K,Abdurishid M,Sieben C,Geissner A,Brinkmann V,Kastner M,Karner A,Zhu R,Hinterdorfer P,Anish C,Seeberger PH,Herrmann A,Meyer TF,Karlas A

更新日期：2016-05-01 00:00:00

abstract：:All lepidopteran baculovirus genomes sequenced to date encode a viral fibroblast growth factor homolog (vfgf), suggesting that vfgf may play an important role in the infection cycle of lepidopteran baculoviruses. Here, we describe the characterization of a Bombyx mori nucleopolyhedrovirus (BmNPV) mutant lacking functi...

journal_title：Virology

authors： Katsuma S,Horie S,Daimon T,Iwanaga M,Shimada T

更新日期：2006-11-10 00:00:00

abstract：:The recent identification of a novel human coronavirus responsible of a SARS-like illness in the Middle-East a decade after the SARS pandemic, demonstrates that reemergence of a SARS-like coronavirus from an animal reservoir remains a credible threat. Because SARS is contracted by aerosolized contamination of the resp...

journal_title：Virology

authors： Escriou N,Callendret B,Lorin V,Combredet C,Marianneau P,Février M,Tangy F

更新日期：2014-03-01 00:00:00

abstract：:Classical swine fever virus (CSFV) nonstructural protein NS5A is a multifunctional protein functioning in regulation of viral genome replication, protein translation and assembly by interaction with viral or host proteins. Here, heat shock protein 27 (Hsp27) has been identified as a novel binding partner of NS5A by us...

journal_title：Virology

authors： Ling S,Luo M,Jiang S,Liu J,Ding C,Zhang Q,Guo H,Gong W,Tu C,Sun J

更新日期：2018-05-01 00:00:00