当前位置： SCI文献检索 > VIROLOGY期刊下所有文献 > Alternative forms of a strain-specific neutralizing antigenic site on the Sindbis virus E2 glycoprotein.

Alternative forms of a strain-specific neutralizing antigenic site on the Sindbis virus E2 glycoprotein.

Abstract：

:Experiments with monoclonal antibodies raised against two laboratory strains of Sindbis virus, SB and SIN, suggested the existence of a strain-specific neutralizing antigenic site (E2-b) on the E2 glycoprotein. A comparison of monoclonal antibody binding patterns and E2 glycoprotein gene sequences of six laboratory strains distinguished three different configurations of E2-b that correlated with specific amino acid substitutions at position 216 of the E2 glycoprotein. Further study of neutralization escape mutants selected with E2-b-specific antibodies confirmed that amino acid 216 is a major determinant of the E2-b antigenic site. Eight of nine mutants showed a coding change at position 216. One neutralization escape mutation created a new glycosylation site at position 213 and resulted in an E2 protein with an altered migration rate in SDS-PAGE. The neutralization escape mutants studied included amino acid substitutions not found in the laboratory strains that revealed differing binding requirements for two E2-b-specific monoclonal antibodies. The E2-b site is contrasted with the E2-c neutralizing antigenic site described previously (R.A. Olmsted, W.J. Meyer, and R.E. Johnston, 1986, Virology 148, 245-254).

journal_name

Virology

journal_title

Virology

authors

Davis NL,Pence DF,Meyer WJ,Schmaljohn AL,Johnston RE

doi

10.1016/0042-6822(87)90175-9

subject

Has Abstract

pub_date

1987-11-01 00:00:00

pages

101-8

issue

1

eissn

0042-6822

issn

1096-0341

journal_volume

161

pub_type

杂志文章

相关文献

VIROLOGY文献大全
  • Replication intermediates of rice tungro bacilliform virus DNA support a replication mechanism involving reverse transcription.

    abstract：:Rice tungro bacilliform virus (RTBV) replication intermediates have been studied in rice plants infected with the virus. Unencapsidated virus-specific molecules were identified which had open circular, linear, supercoiled (SC), strong-stop, single-stranded, linear double-stranded hairpin, and double-stranded with sing...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1994.1577

    authors： Bao Y,Hull R

    更新日期：1994-11-01 00:00:00

  • Liposome-mediated infection of plant protoplasts with tobacco mosaic virus RNA.

    abstract：:Tobacco mosaic virus (TMV) RNA was encapsulated in large unilamellar vesicles (LUV) of phosphatidylserine and was introduced into protoplasts from Vinca rosea suspension cultures. Infection could be effected by brief incubation of protoplasts with the LUV containing TMV-RNA in the presence of either polyethylene glyco...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(81)90203-8

    authors： Fukunaga Y,Nagata T,Takebe I

    更新日期：1981-09-01 00:00:00

  • Overexpression of the HIV-1 gag-pol polyprotein results in intracellular activation of HIV-1 protease and inhibition of assembly and budding of virus-like particles.

    abstract：:Some retroviruses, including HIV-1, regulate the relative amounts of gag and pol gene products by a translational frameshift mechanism. The consequences of altering the ratios of the Gag and Pol proteins were tested using vaccinia virus expression vectors, in which the gag and pol genes were fused by placing them in t...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1993.1174

    authors： Karacostas V,Wolffe EJ,Nagashima K,Gonda MA,Moss B

    更新日期：1993-04-01 00:00:00

  • Myb protein binds to multiple sites in the human T cell lymphotropic virus type 1 long terminal repeat and transactivates LTR-mediated expression.

    abstract：:The members of the c-myb proto-oncogene family encode sequence-specific transcriptional activators. In T cells, expression of c-myb and the related B-myb gene is induced following mitogenic stimulation. Using a purified recombinant protein, we report here that the human T cell lymphotropic virus type 1 (HTLV-1) LTR c...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(92)90044-p

    authors： Bosselut R,Lim F,Romond PC,Frampton J,Brady J,Ghysdael J

    更新日期：1992-02-01 00:00:00

  • The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy.

    abstract：:To accomplish their viral life cycle, lentiviruses such as HIV highjack host proteins, the so-called cellular co-factors of replication. Lens Epithelium-derived Growth factor (LEDGF/p75), a transcriptional co-activator, is a co-factor of HIV-integrase (IN) and is required for the tethering and correct integration of t...

    journal_title：Virology

    pub_type： 杂志文章,评审

    doi：10.1016/j.virol.2012.09.033

    authors： Christ F,Debyser Z

    更新日期：2013-01-05 00:00:00

  • Gag-mos Polyproteins encoded by variants of the Moloney strain of mouse sarcoma virus.

    abstract：:Two revertants of ts110 Moloney murine sarcoma virus (MuSV) with wild-type MuSV phenotype were examined for the presence of mos gene products, ts110 MuSV has a temperature-sensitive defect in a function required to maintain the transformed phenotype. The nonproducer 6m2 cell clone transformed by ts110 produces an 85,0...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(83)90483-x

    authors： Stanker LH,Horn JP,Gallick GE,Kloetzer WS,Murphy EC Jr,Blair DG,Arlinghaus RB

    更新日期：1983-04-15 00:00:00

  • Enhancement of dengue virus translation: role of the 3' untranslated region and the terminal 3' stem-loop domain.

    abstract：:An essential step for a productive infection by the dengue flavivirus (DEN) is translation of the m(7)G-capped, nonpolyadenylated positive-sense RNA genome. We have recently identified sequences within the DEN 3' untranslated region (UTR) that modulate viral translation. Here, we show that the DEN type 2 (DEN2) 3'UTR ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2004.08.004

    authors： Holden KL,Harris E

    更新日期：2004-11-10 00:00:00

  • Polyadenylation function and sequence variability of the long terminal repeats of the human endogenous retrovirus-like family RTVL-H.

    abstract：:The RTVL-H family of human endogenous retrovirus-like sequences consists of approximately 1000 "full-length" elements and at least as many solitary RTVL-H related long terminal repeats (LTRs). We have characterized cDNA clones from two human cell libraries (Hep-2 and normal peripheral blood) and have found three clone...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(89)90570-9

    authors： Mager DL

    更新日期：1989-12-01 00:00:00

  • Inefficient entry of vicriviroc-resistant HIV-1 via the inhibitor-CCR5 complex at low cell surface CCR5 densities.

    abstract：:HIV-1 variants resistant to small molecule CCR5 inhibitors such as vicriviroc (VVC) have modified Env complexes that can use both the inhibitor-bound and -free forms of the CCR5 co-receptor to enter target cells. However, entry via the inhibitor-CCR5 complex is inefficient in some, but not all, cell types, particularl...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2009.02.044

    authors： Pugach P,Ray N,Klasse PJ,Ketas TJ,Michael E,Doms RW,Lee B,Moore JP

    更新日期：2009-05-10 00:00:00

  • The termini of the chlorella virus PBCV-1 genome are identical 2.2-kbp inverted repeats.

    abstract：:The Chlorella virus PBCV-1 genome is a linear nonpermuted 333-kbp dsDNA molecule with covalently closed hairpin termini. The termini (minus the hairpin) are identical inverted repeats of at least 2185 bases after which the sequence diverges. The inverted repeats contain two small potential open reading frames and seve...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(91)90089-t

    authors： Strasser P,Zhang YP,Rohozinski J,Van Etten JL

    更新日期：1991-02-01 00:00:00

  • DNA repair gene expression is increased in HPV positive head and neck squamous cell carcinomas.

    abstract：:The incidence of head and neck squamous cell carcinomas (HNSCCs) is rising in developed countries. This is driven by an increase in HNSCCs caused by high-risk human papillomavirus (HPV) infections or HPV + HNSCCs. Compared to HNSCCs not caused by HPV (HPV- HNSCCs), HPV + HNSCCs are more responsive to therapy and assoc...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2020.07.004

    authors： Holcomb AJ,Brown L,Tawfik O,Madan R,Shnayder Y,Thomas SM,Wallace NA

    更新日期：2020-09-01 00:00:00

  • KSHV LANA and EBV LMP1 induce the expression of UCH-L1 following viral transformation.

    abstract：:Ubiquitin C-terminal Hydrolase L1 (UCH-L1) has oncogenic properties and is highly expressed during malignancies. We recently documented that Epstein-Barr virus (EBV) infection induces uch-l1 expression. Here we show that Kaposi's Sarcoma-associated herpesvirus (KSHV) infection induced UCH-L1 expression, via cooperatio...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2013.10.018

    authors： Bentz GL,Bheda-Malge A,Wang L,Shackelford J,Damania B,Pagano JS

    更新日期：2014-01-05 00:00:00

  • Rapid establishment of stable retroviral packaging cells and recombinant susceptible target cell lines employing novel transposon vectors derived from Sleeping Beauty.

    abstract：:Viral vector particles derived from murine leukemia virus (MLV) mediate highly efficient stable gene transfer used in gene therapeutic approaches and in the generation of transgenic cell lines. However, the establishment of stable viral packaging cells (VPCs) is a time-consuming challenge. To overcome this limitation,...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2019.02.014

    authors： Berg K,Schäfer VN,Bartnicki N,Eggenschwiler R,Cantz T,Stitz J

    更新日期：2019-05-01 00:00:00

  • Two N-terminal regions of the Sendai virus L RNA polymerase protein participate in oligomerization.

    abstract：:The RNA dependent RNA polymerase of Sendai virus consists of a complex of the large (L) and phosphoprotein (P) subunits where L is thought to be responsible for all the catalytic activities necessary for viral RNA synthesis. We previously showed that the L protein forms an oligomer [Smallwood, S., Cevik, B., Moyer, S....

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2007.01.032

    authors： Cevik B,Smallwood S,Moyer SA

    更新日期：2007-06-20 00:00:00

  • Biologically active protease 3C of human rhinovirus 1A is expressed from a cloned cDNA segment in Escherichia coli.

    abstract：:We produced the putative protease 3C of human rhinovirus 1A (HRV-1A), a minor group rhinovirus, by Escherichia coli expression of a segment of HRV-1A cDNA coding for 3A, 3B, 3C, and parts of 2C and 3D (delta 2C3ABC delta 3D). The protease 3C was expected to be processed by intramolecular Q-G cleavages from the virus-s...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(91)90429-f

    authors： Aschauer B,Werner G,McCray J,Rosenwirth B,Bachmayer H

    更新日期：1991-10-01 00:00:00

  • Zoonotic potential of highly pathogenic avian H7N3 influenza viruses from Pakistan.

    abstract：:H5 and H7 avian influenza viruses can become highly pathogenic in chickens after interspecies transmission. These viruses have transmitted directly to humans from birds in Eurasia and Africa (H5N1), the Netherlands (H7N7), and Canada (H7N3). Here we report antigenic, sequence, and phylogenetic analyses of H7N3 viruses...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2009.05.008

    authors： Aamir UB,Naeem K,Ahmed Z,Obert CA,Franks J,Krauss S,Seiler P,Webster RG

    更新日期：2009-08-01 00:00:00

  • Activation of human immunodeficiency virus type 1 provirus in T-cells and macrophages is associated with induction of inducer-specific NF-kappa B binding proteins.

    abstract：:We have analyzed the limiting factors involved in the induction of human immunodeficiency virus type 1 (HIV-1) provirus expression by tumor necrosis factor-alpha (TNF-alpha), phorbol-12-myristate-13-acetate (PMA), and bryostatin-1 in T-cells (ACH-2) and monocytes (U1). We have demonstrated that, while there is a corre...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(92)90295-z

    authors： Vlach J,Pitha PM

    更新日期：1992-03-01 00:00:00

  • Viral cytopathogenicity correlated with integration of ubiquitin-coding sequences.

    abstract：:The RNA genomes of cytopathogenic bovine viral diarrhea virus (BVDV) isolates contain insertions highly homologous to cellular sequences. For two of them the insert was identified as ubiquitin coding sequence. The genome of BVDV Osloss contains exactly one ubiquitin gene monomer. In the case of BVDV CP1 the cellular i...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(91)90074-l

    authors： Meyers G,Tautz N,Dubovi EJ,Thiel HJ

    更新日期：1991-02-01 00:00:00

  • Mutant CD4 molecules with improved binding to HIV envelope protein gp120 selected by phage display.

    abstract：:Phage-display methodology has been used to select variant CD4 proteins exhibiting increased binding to the surface envelope glycoprotein, gp120, of Human Immunodeficiency Virus Type-1. To facilitate the selection, a library of mutant CD4 proteins was constructed by cloning a PCR-generated error prone population of the...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1997.8651

    authors： Krykbaev R,McKeating J,Jones I

    更新日期：1997-08-04 00:00:00

  • Maintenance of human cytomegalovirus genome in human diploid fibroblast cells.

    abstract：:Human embryo lung cells pretreated with a combination of human leukocyte interferon and acyclovir were infected with human cytomegalovirus (HCMV) and treated daily for 14 days with the same inhibitor combination. After removal of the inhibitors, the incubation temperature was maintained at either 37 or 40.5 degrees. I...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(83)90139-3

    authors： Bucher LJ,Wigdahl B,Rapp F

    更新日期：1983-10-15 00:00:00

  • Phosphorylated proteins in cauliflower mosaic virus.

    abstract：:Autoradiography of dodecyl sulfate-impregnated polyacrylamide gels after electrophoresis of the proteins from 32P-labeled cauliflower mosaic virus (CaMV) showed that two of the structural proteins were phosphorylated. These two proteins of 44 and 58 kilodaltons (kd) occur as minor components with some strains of the v...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(80)90294-9

    authors： Hahn P,Shepherd RJ

    更新日期：1980-11-01 00:00:00

  • A new DNA binding protein highly conserved in diverse crenarchaeal viruses.

    abstract：:Sulfolobus turreted icosahedral virus (STIV) infects Sulfolobus species found in the hot springs of Yellowstone National Park. Its 37 open reading frames (ORFs) generally lack sequence similarity to other genes. One exception, however, is ORF B116. While its function is unknown, orthologs are found in three additional...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2007.01.027

    authors： Larson ET,Eilers BJ,Reiter D,Ortmann AC,Young MJ,Lawrence CM

    更新日期：2007-07-05 00:00:00

  • Characterization of modified hepatitis C virus E2 proteins expressed on the cell surface.

    abstract：:The envelope proteins of hepatitis C virus (HCV) are the likely targets of neutralizing antibodies and their molecular and functional characterization is relevant for vaccine development. We previously showed that surface-expressed E2 is a better immunogen than intracellular E2 and, therefore, we were interested in ex...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2000.0419

    authors： Forns X,Allander T,Rohwer-Nutter P,Bukh J

    更新日期：2000-08-15 00:00:00

  • Injection of the sciatic nerve with TMEV: a new model for peripheral nerve demyelination.

    abstract：:Demyelination of the human peripheral nervous system (PNS) can be caused by diverse mechanisms including viral infection. Despite association of several viruses with the development of peripheral demyelination, animal models of the condition have been limited to disease that is either autoimmune or genetic in origin. ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2006.09.009

    authors： Drescher KM,Tracy SM

    更新日期：2007-03-01 00:00:00

  • Changes in the intraisolate genetic structure of Beet necrotic yellow vein virus populations associated with plant resistance breakdown.

    abstract：:The causal agent of rhizomania disease, Beet necrotic yellow vein virus (BNYVV), typically produces asymptomatic root-limited infections in sugar beets (Beta vulgaris) carrying the Rz1-allele. Unfortunately, this dominant resistance has been recently overcome. Multiple cDNA clones of the viral pathogenic determinant p...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2008.03.008

    authors： Acosta-Leal R,Fawley MW,Rush CM

    更新日期：2008-06-20 00:00:00

  • A cytopathic and a cell culture adapted hepatitis A virus strain differ in cell killing but not in intracellular membrane rearrangements.

    abstract：:Aside from a common gene organization shared with other picornaviruses, hepatitis A virus (HAV) is characterized by its slow-growth phenotype, the inability to shut off host macromolecular synthesis, and, in general, lack of cytopathic (cp) effects in permissive cell cultures. Nevertheless, several cp HAV strains have...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1999.0070

    authors： Gosert R,Egger D,Bienz K

    更新日期：2000-01-05 00:00:00

  • Sequences within the early and late promoters of archetype JC virus restrict viral DNA replication and infectivity.

    abstract：:Two forms of JC virus (JCV) have been isolated from its human host, an archetype found in kidney tissue and urine of nonimmunocompromised individuals and a rearranged type detected in lymphocytes and brain tissue of patients with and without progressive multifocal leukoencephalopathy. To investigate the hypothesis tha...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1996.0037

    authors： Daniel AM,Swenson JJ,Mayreddy RP,Khalili K,Frisque RJ

    更新日期：1996-02-01 00:00:00

  • Domain- and nucleotide-specific Rev response element regulation of feline immunodeficiency virus production.

    abstract：:Computational analysis of feline immunodeficiency virus (FIV) RNA sequences indicated that common FIV strains contain a rev response element (RRE) defined by a long unbranched hairpin with 6 stem-loop sub-domains, termed stem-loop A (SLA). To examine the role of the RNA secondary structure of the RRE, mutational analy...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2010.04.009

    authors： Na H,Huisman W,Ellestad KK,Phillips TR,Power C

    更新日期：2010-09-01 00:00:00

  • Genetic variation among dengue 2 viruses of different geographic origin.

    abstract：:Genetic variation in dengue 2 isolates from various geographic areas was examined by oligonucleotide fingerprinting of the 40 S genome RNA. Oligonucleotide maps of geographically isolated and epidemiologically unrelated viruses were very distinct. Direct comparison of the oligonucleotide map of the dengue 2 prototype ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(83)90255-6

    authors： Trent DW,Grant JA,Rosen L,Monath TP

    更新日期：1983-07-30 00:00:00

  • Adenovirus infection inactivates the translational inhibitors 4E-BP1 and 4E-BP2.

    abstract：:Infection with many viruses results in the selective shutoff of host protein synthesis. A common target for virus interference with host protein synthesis is the cap-binding protein complex, eIF4F. The large subunit of the complex, eIF4G, is cleaved upon picornavirus (except cardiovirus) infection. Infection with aden...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1997.8757

    authors： Gingras AC,Sonenberg N

    更新日期：1997-10-13 00:00:00