Abstract:
:Marek' disease virus serotype-1, also know as Gallid herpesvirus 2 (GaHV-2), elicits T-cell lymphomas in chickens. The GaHV-2 genome encodes an oncoprotein, Meq, with similarity to the Jun/Fos family of proteins. We have previously shown that Meq homodimers are not sufficient to induce lymphomas in chickens. In this study, we investigated the role of Meq heterodimers in the pathogenicity of GaHV-2 by generating a chimeric meq gene, which contains the leucine zipper region of Fos (meqFos). A recombinant virus containing the meqFos gene in place of parental meq, rMd5-MeqFos, was not capable of transforming chicken lymphocytes, indicating that heterodimerization of Meq alone is not sufficient for transformation. In addition, the recovery of the oncogenic phenotype by a recombinant virus encoding one copy each of MeqGCN (homodimer) and MeqFos (heterodimer) conclusively demonstrates that both homo and heterodimerization of Meq are required for oncogenesis.
journal_name
Virologyjournal_title
Virologyauthors
Suchodolski PF,Izumiya Y,Lupiani B,Ajithdoss DK,Lee LF,Kung HJ,Reddy SMdoi
10.1016/j.virol.2010.01.006subject
Has Abstractpub_date
2010-04-10 00:00:00pages
312-21issue
2eissn
0042-6822issn
1096-0341pii
S0042-6822(10)00016-4journal_volume
399pub_type
杂志文章相关文献
VIROLOGY文献大全abstract::Ribavirin is the first synthetic, broad-spectrum antiviral nucleoside. Despite its more than 30 year history, the mechanism of action of this compound remains unclear and somewhat controversial. Recent data suggest the possibility that the activity of ribavirin against RNA viruses is a reflection of incorporation of r...
journal_title:Virology
pub_type: 杂志文章,评审
doi:10.1006/viro.2002.1487
更新日期:2002-07-05 00:00:00
abstract::The genome of the Bacillus subtilis phage SP01 contains a 12.6-kilobase-pair terminal redundancy. The transcription units in this region, which are utilized in vitro by B. subtilis RNA polymerase holoenzme, have been mapped. In vitro transcripts were separated and characterized by gel electrophoresis. Since there is s...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(81)90361-5
更新日期:1981-06-01 00:00:00
abstract::Next generation sequence analyses were used to assess virus-derived small RNA (vsRNA) profiles for Homalodisca coagulata virus-1 (HoCV-1), family Dicistroviridae, and Homalodisca vitripennis reovirus (HoVRV), family Reoviridae, from virus-infected H. vitripennis, the glassy-winged sharpshooter. The vsRNA reads were ma...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.04.005
更新日期:2013-07-20 00:00:00
abstract::A subtype of human papillomavirus 5 (HPV-5b) is closely associated with carcinomas in the disease epidermodysplasia verruciformis (EV). The complete genome was cloned from virus particles in benign lesions of a patient with EV and sequenced: it was 7779 nucleotides long and consisted of six open reading frames (ORFs) ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(91)91013-7
更新日期:1991-08-01 00:00:00
abstract::The efficacy of combining immunization with human immunodeficiency vitus type 1 (HIV-1) DNA and HIV-1 recombinant proteins to obtain protection from chimeric simian/human immunodeficiency virus (SHIV) was determined. Four cynomolgus monkeys received four gene-gun immunizations intraepidermally of plasmid DNA encoding ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1998.9379
更新日期:1998-10-25 00:00:00
abstract::Human adenovirus type 5 (Ad5) has been the most popular platform for the development of oncolytic Ads. Alternative Ad serotypes with low seroprevalence might allow for improved anticancer efficacy in Ad5-immune patients. We studied the safety and efficacy of rare serotypes Ad6, Ad11 and Ad35. In vitro cytotoxicity of ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2009.08.038
更新日期:2009-11-25 00:00:00
abstract::Dendrolimus punctatus tetravirus (DpTV) belongs to the genus omegatetravirus of the Alphatetraviridae family. Sequence analysis predicts that DpTV replicase contains a putative helicase domain (Hel). However, the helicase activity in alphatetraviruses has never been formally determined. In this study, we determined th...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.08.045
更新日期:2012-11-25 00:00:00
abstract::We have investigated the interaction of SV40 virions with polarized monkey kidney epithelial cells. Virions were tagged with biotin to facilitate their detection and were found to retain full infectivity. When polarized Vero C1008 cells were incubated with biotinylated virions followed by a strepavidin-rhodamine conju...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(92)91225-j
更新日期:1992-09-01 00:00:00
abstract::Determinants of temperature sensitivity and/or attenuation in Sabin type 1 poliovirus reside in the 5' NTR and coding sequences of the capsid proteins and viral RNA polymerase, 3D(pol). Previous studies have implicated at least two mutations in 3D(pol) of Sabin 1 vaccine strain [PV1(S)], including a Y73H change, as co...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2000.0354
更新日期:2000-06-20 00:00:00
abstract::We report the discovery of Nylanderia fulva virus 1 (NfV-1), the first virus identified and characterized from the ant, Nylanderia fulva. The NfV-1 genome (GenBank accession KX024775) is 10,881 nucleotides in length, encoding one large open reading frame (ORF). Helicase, protease, RNA-dependent RNA polymerase, and jel...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2016.06.014
更新日期:2016-09-01 00:00:00
abstract::We examined the molecular epidemiology and evolution of Ross River (RR) virus in Australia and the Pacific Islands. Nucleotide sequences of the E2 and E3 genes of five RR virus strains revealed remarkable conservation between 1959 and 1989 with a maximum divergence of only 3.3%. Sequence data from a 505-base pair frag...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1995.1449
更新日期:1995-09-10 00:00:00
abstract::Human infections with highly pathogenic H5N1 avian influenza viruses continue to occur in many parts of the world and pose a considerable public health threat. With the use of animal models, the identification of virulence determinants has been instrumental in improving our understanding of how these viruses cause sev...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.02.005
更新日期:2011-05-10 00:00:00
abstract::The replication of vaccinia virus was reduced by 3 logs in cells that had been treated before and during infection with a concentration of N-(phosphonoacetyl)-L-aspartate (PALA) which lowered the UTP and CTP to 5 and 20% of controls, respectively, without affecting cell viability. The antiviral activity of PALA was re...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1997.8735
更新日期:1997-09-15 00:00:00
abstract::We have used a yeast two-hybrid system to identify a baculoviral gene encoding a protein kinase-interacting protein (PKIP). The pkip gene is located at 15.8-16.2 m.u (map units) and represents ORF 24 in the sequence of Ayres et al. (1994) of the Autographa californica nuclear polyhedrosis virus. PKIP is a 19.2-kDa pro...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1997.8944
更新日期:1998-01-20 00:00:00
abstract::Superinfection exclusion (SIE), a phenomenon in which a preexisting viral infection prevents a secondary infection with the same or closely related virus, has been described for different viruses, including important pathogens of humans, animals, and plants. Several mechanisms acting at various stages of the viral lif...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.08.031
更新日期:2014-11-01 00:00:00
abstract::Lysolecithin permeabilization of vaccinia virus-infected cells was employed to prepare extracts that support faithful transcription initiation in vitro on plasmids possessing early, intermediate, and late viral gene promoters. Conditions which optimize transcription from each promoter were defined. The in vitro system...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1996.0177
更新日期:1996-04-01 00:00:00
abstract::In vivo infection with human immunodeficiency virus type 1 (HIV-1) leads to gradual depletion of CD4+ T lymphocytes from the peripheral blood and later from the lymphoid organs. The mechanism of CD4 cell depletion is not known. HIV can only replicate in dividing lymphocytes, but greater than 98% of the lymphocytes in ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1996.8397
更新日期:1997-02-17 00:00:00
abstract::Binding of simian virus 40 (SV40) large T antigen to human and calf thymus topoisomerase I (topo I) was readily detected by using modified enzyme-linked immunosorbent assays and immunoblots. In addition to WT T antigen, binding could also be readily demonstrated with T antigen fragments from the amino-terminal region ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1996.0433
更新日期:1996-08-15 00:00:00
abstract::Propagation of human influenza viruses in embryonated chicken eggs (CE) results in the selection of variants with amino acid substitutions near the receptor-binding site of the hemagglutinin (HA) molecule. To evaluate the mechanisms by which these substitutions enable human virus growth in CE, we studied the binding o...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1999.9732
更新日期:1999-06-05 00:00:00
abstract::Previous studies with monoclonal antibodies of the antigenic structure of bovine leukemia virus (BLV) envelope glycoprotein (gp51) have identified three epitopes (F, G, H) directly involved in the infectivity of BLV, F, G, and H lost their reactivity with the respective monoclonal antibodies after treatment with a red...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(89)90037-8
更新日期:1989-03-01 00:00:00
abstract::A chloroplast-localized papaya methionine sulfoxide reductase B1 (PaMsrB1) interacting with Papaya ringspot virus (PRSV) NIa-Pro was identified using a Sos recruitment two-hybrid system (SRS). SRS analysis of several deletion mutants of PRSV NIa-Pro and PaMsrB1 demonstrated that the C-terminal (residues 133-239) fragm...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.09.007
更新日期:2012-12-05 00:00:00
abstract::Monoclonal antibodies to the matrix or E1 glycoprotein of mouse hepatitis virus (MHV) were tested for their ability to protect mice from a normally lethal challenge of MHV-4. Four antibodies were tested, and two of these, J.1.3 and J.3.9, were protective. Protection did not correlate with virus neutralization in vitro...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(89)90415-7
更新日期:1989-01-01 00:00:00
abstract::Old world hantaviruses, causing hemorrhagic fever with renal syndrome (HFRS), still present a public health problem in Asia and Eastern Europe. The majority of cases has been recorded in China. The aim of our study was to generate human recombinant neutralizing antibodies to a hantavirus by phage display technology. T...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/s0042-6822(02)00094-6
更新日期:2003-03-30 00:00:00
abstract::The hemagglutinin of the 2009 pandemic H1N1 influenza virus is a derivative of and is antigenically related to classical swine but not to seasonal human H1N1 viruses. We compared the A/California/7/2009 (CA/7/09) virus recommended by the WHO as the reference virus for vaccine development, with two classical swine infl...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2010.09.009
更新日期:2010-12-05 00:00:00
abstract::Rotavirus infection was studied in adult nude mice (BALB/c background), alpha beta or gamma delta and alpha beta/gamma delta T cell receptor (TCR) knockout (-/-) mice (C57BL/6 and C57BL/6 x 129 backgrounds), and SCID mice (C57BL/6 background). The gamma delta TCR -/- mice cleared infection just like control mice. All ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1997.8843
更新日期:1997-11-24 00:00:00
abstract::The CC chemokine receptor (CCR) 7 ligands CCL21 and CCL19 were recently described as essential elements for establishing the microenvironment needed to initiate optimal immune responses in secondary lymphoid tissues. In the present study we have kinetically investigated the primary responses of naive DO11.10 TCR-trans...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/s0042-6822(03)00199-5
更新日期:2003-07-20 00:00:00
abstract::A novel human papillomavirus type (HPV) was cloned from an invasive cervical carcinoma. The viral clone showed no homology with other known prototypes of HPV (HPV-1 through HPV-57), except HPV-33 by Southern blot analysis under stringent conditions. It showed less than 20% homology to HPV-33 by reassociation kinetic a...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(90)90560-e
更新日期:1990-08-01 00:00:00
abstract::Rice dwarf virus (RDV) spreads, along actin-based filopodia, as one of the ways of its transport, from infected to non-infected cells of its vector insect via tubules that are composed of the viral nonstructural protein Pns10 and contain viral particles. An inhibitor that perturbs the endomembrane system, namely, bref...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2007.10.034
更新日期:2008-03-15 00:00:00
abstract::Genetic variation in dengue 2 isolates from various geographic areas was examined by oligonucleotide fingerprinting of the 40 S genome RNA. Oligonucleotide maps of geographically isolated and epidemiologically unrelated viruses were very distinct. Direct comparison of the oligonucleotide map of the dengue 2 prototype ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(83)90255-6
更新日期:1983-07-30 00:00:00
abstract::There is growing evidence that the receptor-binding characteristics of influenza viruses are affected by the host-dependent glycosylation of viral hemagglutinin (HA). To better understand these effects, we propagated two variants of the human influenza virus USSR/90/77 (which differed by the mutation Asn131 reversible...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1998.9224
更新日期:1998-08-01 00:00:00