当前位置： SCI文献检索 > VIROLOGY期刊下所有文献 > Arginine or lysine in position 333 of ERA and CVS glycoprotein is necessary for rabies virulence in adult mice.

Arginine or lysine in position 333 of ERA and CVS glycoprotein is necessary for rabies virulence in adult mice.

Abstract：

:Fixed rabies virus strains (ERA and CVS) produce a fatal paralytic disease in mice after intracerebral or intramuscular injection. Some antigenic mutants of both CVS and ERA viruses with a substitution in position 333 of the glycoprotein (arginine is replaced either by a glutamine, a glycine, or an isoleucine) are totally avirulent for adult mice whatever the dose and the route of inoculation. Here we report an exhaustive investigation of the effect of amino acid 333 on viral virulence. New antigenic mutants were isolated from either CVS, CVS derivatives, or SADBern having arginine in position 333 encoded by CGG, AGG, CGU, or AGA respectively. This study shows that when arginine is replaced by either a leucine, an isoleucine, a methionine, a cysteine, or a serine, the antigenic mutant is also totally avirulent. But when arginine is replaced by a lysine it is still pathogenic although the LD50 by the intracerebral route is higher. Furthermore 41 independent virulent revertants were isolated from four avirulent mutants (with a glycine, a glutamine, a methionine, or a serine in position 333 of the glycoprotein). Thirty-nine regained an arginine at position 333 and 2 had a lysine. From this analysis it appears that the presence of a positively charged amino acid (arginine or lysine) in position 333 of the glycoprotein is necessary for viral virulence.

journal_name

Virology

journal_title

Virology

authors

Tuffereau C,Leblois H,Bénéjean J,Coulon P,Lafay F,Flamand A

doi

10.1016/0042-6822(89)90122-0

subject

Has Abstract

pub_date

1989-09-01 00:00:00

pages

206-12

issue

1

eissn

0042-6822

issn

1096-0341

journal_volume

172

pub_type

杂志文章

相关文献

VIROLOGY文献大全
  • Genomic cartography of varicella-zoster virus: a complete genome-based analysis of strain variability with implications for attenuation and phenotypic differences.

    abstract：:In order to gain a better perspective on the true variability of varicella-zoster virus (VZV) and to catalogue the location and number of differences, 11 new complete genome sequences were compared with those previously in the public domain (18 complete genomes in total). Three of the newly sequenced genomes were deri...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2006.09.037

    authors： Tyler SD,Peters GA,Grose C,Severini A,Gray MJ,Upton C,Tipples GA

    更新日期：2007-03-15 00:00:00

  • In vivo complementation of infectious transcripts from mutant tobacco mosaic virus cDNAs in transgenic plants.

    abstract：:A full-length cDNA clone of the U1 (common) strain of tobacco mosaic virus (TMV) was constructed, and highly infectious transcripts were produced in vitro using bacteriophage T7 RNA polymerase. Frameshift mutations designed to cause premature termination of translation were introduced into either the 30-kDa movement p...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(91)90475-q

    authors： Holt CA,Beachy RN

    更新日期：1991-03-01 00:00:00

  • The complete genomic sequence of lytic bacteriophage gh-1 infecting Pseudomonas putida--evidence for close relationship to the T7 group.

    abstract：:The genome of the lytic Pseudomonas putida bacteriophage gh-1 is linear double-stranded DNA containing 37,359 bp with 216-bp direct terminal repeats. Like other members of the T7 group, the gh-1 genome contains regions of high homology to T7 interspersed with nonhomologous regions that contain small open reading frame...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/s0042-6822(03)00124-7

    authors： Kovalyova IV,Kropinski AM

    更新日期：2003-07-05 00:00:00

  • Selection and characterisation of acyclovir-resistant herpes simplex virus type 1 mutants inducing altered DNA polymerase activities.

    abstract：:A collection of TK+, ACV-resistant mutants of herpes simplex virus type 1 (HSV-1) has been derived using a selection system based on biochemically transformed cells. Evidence is presented suggesting that most of these mutants induce resistant DNA polymerase activities and are thus likely to express variant DNA polymer...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(85)90009-1

    authors： Larder BA,Darby G

    更新日期：1985-10-30 00:00:00

  • Simian Immunodeficiency Virus seroreactivity in inhabitants from rural Cameroon frequently in contact with non-human primates.

    abstract：:Central African tropical forests are home to several species of non-human primates (NHPs), infected by Simian Immunodeficiency Virus (SIV). It is well-known that HIV-1 epidemic is due to cross-transmission and adaptation of SIV to humans. The main goal of this work was to investigate if a NHP bite is a risk factor for...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2016.12.026

    authors： Filippone C,de Oliveira F,Betsem E,Schaeffer L,Fontanet A,Lemée V,Gessain A,Plantier JC

    更新日期：2017-03-01 00:00:00

  • Characterization of a 105-kDa plasma membrane associated glycoprotein that is involved in West Nile virus binding and infection.

    abstract：:This study attempts to isolate and characterize West Nile virus-binding molecules on the plasma membrane of Vero and murine neuroblastoma cells that is responsible for virus entry. Pretreatment of Vero cells with proteases, glycosidases (endoglycosidase H, alpha-mannosidase), and sodium periodate strongly inhibited We...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/s0042-6822(03)00261-7

    authors： Chu JJ,Ng ML

    更新日期：2003-08-01 00:00:00

  • Mutations increasing exposure of a receptor binding site epitope in the soluble and oligomeric forms of the caprine arthritis-encephalitis lentivirus envelope glycoprotein.

    abstract：:The caprine arthritis-encephalitis (CAEV) and ovine maedi-visna (MVV) viruses are resistant to antibody neutralization, a feature shared with all other lentiviruses. Whether the CAEV gp135 receptor binding site(s) (RBS) in the functional surface envelope glycoprotein (Env) is protected from antibody binding, allowing ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2005.05.028

    authors： Hötzel I,Cheevers WP

    更新日期：2005-09-01 00:00:00

  • Mutational analysis of the Sendai virus V protein: importance of the conserved residues for Zn binding, virus pathogenesis, and efficient RNA editing.

    abstract：:The V protein of Sendai virus (SeV) is nonessential for virus replication in cell culture but indispensable for viral pathogenicity in mice. At the C terminus of the V protein, there are amino acid residues conserved among the members of the Paramyxovinae subfamily that are clustered in three regions: region I, just d...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2002.1516

    authors： Fukuhara N,Huang C,Kiyotani K,Yoshida T,Sakaguchi T

    更新日期：2002-08-01 00:00:00

  • Population diversity in grapevine yellow speckle viroid-1 and the relationship to disease expression.

    abstract：:Vitis vinifera cultivars Zinfandel-1A and Mission were found to harbor different grapevine yellow speckle viroid-1 (GYSVd-1) variants and characterized to define the relationship to yellow speckle (YS) and vein-banding (VB) diseases. Products from the left terminal (T1), pathogenic (P), and a portion of the central (C...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1998.9292

    authors： Szychowski JA,Credi R,Reanwarakorn K,Semancik JS

    更新日期：1998-09-01 00:00:00

  • An infectious West Nile virus that expresses a GFP reporter gene.

    abstract：:West Nile virus is a mosquito-borne, neurotropic flavivirus that causes encephalitis in humans and animals. Since being introduced into the Western hemisphere in 1999, WNV has spread rapidly across North America, identifying this virus as an important emerging pathogen. In this study, we developed a DNA-launched infec...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2005.01.021

    authors： Pierson TC,Diamond MS,Ahmed AA,Valentine LE,Davis CW,Samuel MA,Hanna SL,Puffer BA,Doms RW

    更新日期：2005-03-30 00:00:00

  • Characterization of a nonhemagglutinating mutant of canine parvovirus.

    abstract：:A nonhemagglutinating mutant of a 1978 isolate of canine parvovirus (CPV) was derived after repeated passages in the NLFK feline kidney cell line. The mutant CPV was antigenically indistinguishable from wild-type virus when tested with 82 monoclonal antibodies, and it replicated in cat and dog cell lines in culture. S...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(88)90255-3

    authors： Parrish CR,Burtonboy G,Carmichael LE

    更新日期：1988-03-01 00:00:00

  • In vitro differentiation of monocytoid THP-1 cells affects their permissiveness for HIV strains: a model system for studying the cellular basis of HIV differential tropism.

    abstract：:The prototypic macrophage-tropic HIV-1 isolate, HIV-1BaL, cannot replicate in the monocytoid cell line THP-1. After induction of differentiation by a phorbol diester, a fraction of THP-1 cells became permissive to HIV-1BaL. In contrast, this treatment decreased permissiveness for the lymphotropic isolate HIV-1LAI. Vir...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1993.1121

    authors： Meylan PR,Spina CA,Richman DD,Kornbluth RS

    更新日期：1993-03-01 00:00:00

  • Raccoon poxvirus feline panleukopenia virus VP2 recombinant protects cats against FPV challenge.

    abstract：:An infectious raccoon poxvirus (RCNV) was used to express the feline panleukopenia virus (FPV) open reading frame VP2. The recombinant, RCNV/FPV, was constructed by homologous recombination with a chimeric plasmid for inserting the expression cassette into the thymidine kinase (TK) locus of RCNV. Expression of the VP2...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1996.0186

    authors： Hu L,Esposito JJ,Scott FW

    更新日期：1996-04-01 00:00:00

  • The satellite RNA of barley yellow dwarf virus-RPV is supported by beet western yellows virus in dicotyledonous protoplasts and plants.

    abstract：:The subgroup II luteovirus barley yellow dwarf virus-RPV (BYDV-RPV) acts as a helper virus for a satellite RNA (satRPV RNA). The subgroup II luteovirus beet western yellows virus (BWYV) and the ST9-associated RNA (ST9a RNA), a BWYV-associated RNA that encodes a polymerase similar to those of subgroup I luteoviruses, w...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1997.8532

    authors： Rasochová L,Passmore BK,Falk BW,Miller WA

    更新日期：1997-05-12 00:00:00

  • Overexpression of adenovirus E3-11.6K protein induces cell killing by both caspase-dependent and caspase-independent mechanisms.

    abstract：:Recent studies have shown enhanced antitumor efficacy with adenoviruses that either lack E1B-19K or overexpress E3-11.6K (also known as adenoviral death protein). E1B-19K is a well-characterized anti-apoptotic protein, and viruses with E1B-19K deletions show increased cytopathicity. However, the mechanism of cell kill...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2004.06.007

    authors： Zou A,Atencio I,Huang WM,Horn M,Ramachandra M

    更新日期：2004-09-01 00:00:00

  • Molecular basis for naturally occurring elevated readthrough transcription across the M-F junction of the paramyxovirus SV5.

    abstract：:Transcription of the paramyxovirus RNA genome is thought to involve a sequential stop-start mechanism whereby monocistronic mRNAs are produced by polyadenylation and termination of 3' upstream gene followed by reinitiation at the downstream start site. For a number of paramyxoviruses, transcription across the M-F gene...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1998.9266

    authors： Rassa JC,Parks GD

    更新日期：1998-08-01 00:00:00

  • Transcriptional repression of K-Rta by Kaposi's sarcoma-associated herpesvirus K-bZIP is not required for oriLyt-dependent DNA replication.

    abstract：:Kaposi's sarcoma-associated herpesvirus origin-dependent DNA replication requires the core replication proteins plus K-Rta and K-bZIP. To determine which K-bZIP protein domains contribute to oriLyt-dependent DNA replication and facilitate suppression of K-Rta-mediated transcriptional activation, we generated a series ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2007.08.019

    authors： Rossetto C,Gao Y,Yamboliev I,Papousková I,Pari G

    更新日期：2007-12-20 00:00:00

  • Analysis of a baculovirus lacking a functional viral fibroblast growth factor homolog.

    abstract：:Baculoviruses encode fibroblast growth factor (vfgf) homologs whose function during virus infection is unknown. We constructed a recombinant bacmid of Autographa californica M nucleopolyhedrovirus (AcMNPV) lacking a functional vfgf and characterized it in two insect cell lines. The kinetics of budded virus production ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2006.01.016

    authors： Detvisitsakun C,Hutfless EL,Berretta MF,Passarelli AL

    更新日期：2006-03-15 00:00:00

  • Role of dendritic cells infected with human herpesvirus 6 in virus transmission to CD4(+) T cells.

    abstract：:Human herpesvirus 6 (HHV-6) is a ubiquitous betaherpesvirus that predominantly infects and replicates in CD4(+) T lymphocytes. However, the mechanism of HHV-6 transmission to T cells from the peripheral mucosa is unknown. Here we found that dendritic cells (DCs) can transmit HHV-6 to T cells, resulting in productive i...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2008.11.049

    authors： Takemoto M,Imasawa T,Yamanishi K,Mori Y

    更新日期：2009-03-15 00:00:00

  • Measles virus persistence in an immortalized murine macrophage cell line.

    abstract：:Persistent infection with the Edmonston strain of measles virus (MV) has been established in IC-21 cells, an immortalized murine macrophage cell line. Persistence was established immediately without syncytia formation or cytopathic effects. MV was expressed in the majority of the cells as evidenced by immunofluorescen...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1995.1047

    authors： Goldman MB,Buckthal DJ,Picciotto S,O'Bryan TA,Goldman JN

    更新日期：1995-02-20 00:00:00

  • African swine fever virus EP153R open reading frame encodes a glycoprotein involved in the hemadsorption of infected cells.

    abstract：:The open reading frame EP153R, located within the EcoRI E' fragment of the African swine fever (ASF) virus genome, is predicted to encode a membrane protein of 153 amino acids that presents significant homology to the N-terminal region of several CD44 molecules. EP153R contains multiple putative sites for N-glycosylat...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1999.0080

    authors： Galindo I,Almazán F,Bustos MJ,Viñuela E,Carrascosa AL

    更新日期：2000-01-20 00:00:00

  • Murine leukemia virus recombinants that use phosphate transporters for cell entry induce similar spongiform encephalomyelopathies in newborn mice.

    abstract：:Amphotropic Moloney-murine leukemia virus recombinants (Mo-AmphoV) induce a severe spongiform encephalomyelopathy in newborn mice. We show here that a coisogenic recombinant with a 10A1-MuLV host range (Mo-10A1V) also induces a neurodegenerative disease, clinically characterized by mild tremor and ataxia. Spongiform l...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1998.9476

    authors： Münk C,Thomsen S,Stocking C,Löhler J

    更新日期：1998-12-20 00:00:00

  • The DNA of bacteriophage 643: isolation and properties of the DNA of a bacteriophage infecting lactic Streptococci.

    abstract：:The DNA extracted from bacteriophage 643, which infects group N strains of Streptococci, could be separated into four components by electrophoresis on agarose gels. Electron microscopy established the predominant form of the DNA to be a relaxed, circular molecule of molecular weight 14.9 X 10(6). The four species obse...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(84)90406-9

    authors： Lyttle DJ,Petersen GB

    更新日期：1984-03-01 00:00:00

  • Influenza virus is not restricted by tetherin whereas influenza VLP production is restricted by tetherin.

    abstract：:Tetherin (ST2/CD317) is a cellular protein that restricts the release from cells of some enveloped viruses including HIV-1. To examine if influenza virus is affected by tetherin, MDCK cells constitutively expressing human tetherin and control MDCK cells were infected with influenza virus. No difference was observed in...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2011.05.006

    authors： Watanabe R,Leser GP,Lamb RA

    更新日期：2011-08-15 00:00:00

  • Two domains distantly related to protein-tyrosine kinases in the vesicular stomatitis virus polymerase.

    abstract：:We have carried out an exhaustive search for amino acid sequence similarities between vesicular stomatitis virus (VSV) proteins and database entries. Unexpectedly, we found that the L polymerase protein contains two blocks of sequence (residues 725-1102 and 1291-1671) with distant but statistically significant similar...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(89)90148-7

    authors： McClure MA,Perrault J

    更新日期：1989-09-01 00:00:00

  • Comparative analysis of the roles of simian immunodeficiency and bovine leukemia virus matrix proteins in Gag assembly in insect cells.

    abstract：:The role of the matrix (MA) domain of simian immunodeficiency virus (SIV) and bovine leukaemia virus (BLV) Gag in the assembly of virus-like particles (VLP) in insect cells has been investigated. Wild-type SIV and BLV Gag assembled to form discrete VLP structures typical of many retroviruses analysed by similar system...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2002.1441

    authors： Kakker NK,Mikhailov MV,Jones IM,Roy P

    更新日期：2002-07-20 00:00:00

  • The Epstein-Barr virus latent membrane protein 2A PY motif recruits WW domain-containing ubiquitin-protein ligases.

    abstract：:Latent membrane protein 2A (LMP2A) is expressed in latent Epstein-Barr virus (EBV) infection. LMP2A functions to downregulate B-cell signal transduction and viral reactivation from latency in EBV-immortalized B cells in vitro, and acts to provide B cells with both a survival and developmental signal in vivo. Identific...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1999.0166

    authors： Ikeda M,Ikeda A,Longan LC,Longnecker R

    更新日期：2000-03-01 00:00:00

  • Hepatitis B virus polymerase suppresses translation of pregenomic RNA via a mechanism involving its interaction with 5' stem-loop structure.

    abstract：:The pregenomic RNA (pgRNA) of hepadnaviruses serves a dual role: as mRNA for the core (C) and polymerase (P) synthesis and as an RNA template for viral genome replication. A question arises as to how these two roles are regulated. We hypothesized that the P protein could suppress translation of the pgRNA via its inter...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2007.11.010

    authors： Ryu DK,Kim S,Ryu WS

    更新日期：2008-03-30 00:00:00

  • Characterization of the role of individual protein binding motifs within the hepatitis B virus enhancer I on X promoter activity using linker scanning mutagenesis.

    abstract：:A combination of linker scanning mutagenesis and deletional analyses has been used to determine the role of individual DNA-protein binding sites on expression from the hepatitis B virus (HBV) enhancer I-X promoter (map position (mp) 1042-1354, HBV adw2). Linker scanning mutation of the EF-C site caused a 67.5% drop in...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1993.1173

    authors： Gustin K,Shapiro M,Lee W,Burk RD

    更新日期：1993-04-01 00:00:00

  • Anti-HIV designer T cells progressively eradicate a latently infected cell line by sequentially inducing HIV reactivation then killing the newly gp120-positive cells.

    abstract：:The current antiretroviral therapy (ART) can effectively reduce plasma HIV loads to undetectable levels, but cannot eliminate latently infected resting memory CD4 T cells that persist for the lifetime of infected patients. Therefore, designing new therapeutic approaches to eliminate these latently infected cells or th...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2013.08.002

    authors： Sahu GK,Sango K,Selliah N,Ma Q,Skowron G,Junghans RP

    更新日期：2013-11-01 00:00:00