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Analysis of a baculovirus lacking a functional viral fibroblast growth factor homolog.

Abstract：

:Baculoviruses encode fibroblast growth factor (vfgf) homologs whose function during virus infection is unknown. We constructed a recombinant bacmid of Autographa californica M nucleopolyhedrovirus (AcMNPV) lacking a functional vfgf and characterized it in two insect cell lines. The kinetics of budded virus production were similar in the parental and vfgf-deficient viruses in both cell lines at both high and low multiplicities of infection. In addition, no obvious differences were observed between the mutant and parental viruses in protein or DNA synthesis. Finally, coinfection of vfgf-containing and -deficient viruses and passage for several generations did not reveal a consistent growth advantage for either virus.

journal_name

Virology

journal_title

Virology

authors

Detvisitsakun C,Hutfless EL,Berretta MF,Passarelli AL

doi

10.1016/j.virol.2006.01.016

subject

Has Abstract

pub_date

2006-03-15 00:00:00

pages

258-65

issue

2

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(06)00030-4

journal_volume

346

pub_type

杂志文章

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