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The neutralizing antibody response against West Nile virus in naturally infected horses.

Abstract：

:A major neutralizing epitope (here referred to as the T332 epitope) located on the lateral surface of domain III (DIII) of the West Nile virus (WNV) envelope protein has been identified based on the analysis of murine monoclonal antibodies. However, little is known about the humoral immune response against WNV in a natural host or whether DIII in general or the T332 epitope in particular are important targets of neutralizing antibodies in vivo. To characterize the types of antibodies produced during infection with WNV, we studied a group of naturally infected horses. Using immune adsorption assays coupled with the use of virus particles bearing mutations in the T332 epitope, we found that in some animals neutralizing activity against DIII and the T332 epitope was below the limit of detection. In contrast, some animals generated a significant fraction of neutralizing activity to DIII and the T332 epitope. Thus, while antibodies to the T332 epitope did not represent a significant fraction of the total antibody response in the infected animals studied, in some horses, they comprised a significant fraction of neutralizing activity, making this an important but far from dominant neutralizing epitope. Rather, the neutralizing response to WNV generated in infected horses is both variable and polyclonal in nature, with epitopes within and outside of DIII playing important roles.

journal_name

Virology

journal_title

Virology

authors

Sánchez MD,Pierson TC,Degrace MM,Mattei LM,Hanna SL,Del Piero F,Doms RW

doi

10.1016/j.virol.2006.08.047

subject

Has Abstract

pub_date

2007-03-15 00:00:00

pages

336-48

issue

2

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(06)00619-2

journal_volume

359

pub_type

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