Abstract:
:Chemokines play critical roles in HIV-1 infection, serving both to modulate viral replication and to recruit target cells to sites of infection. Interferon-gamma-inducible protein 10 (IP-10/CXCL10) is a C-X-C chemokine that acts specifically upon activated T cells and macrophages and attracts T cells into the cerebrospinal fluid (CSF) in HIV-associated neurological disease. We now demonstrate that IP-10 stimulates HIV-1 replication in monocyte-derived macrophages and peripheral blood lymphocytes. We further demonstrate that neutralization of endogenous IP-10 or blocking the function of its receptor, CXCR3, reduces HIV-1 replication in these same cells. Therefore, blocking the interaction between IP-10 and CXCR3 represents a possible new target for anti-retroviral therapy.
journal_name
Virologyjournal_title
Virologyauthors
Lane BR,King SR,Bock PJ,Strieter RM,Coffey MJ,Markovitz DMdoi
10.1016/s0042-6822(02)00045-4subject
Has Abstractpub_date
2003-03-01 00:00:00pages
122-34issue
1eissn
0042-6822issn
1096-0341pii
S0042682202000454journal_volume
307pub_type
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