Evolution of poliovirus type I during 5.5 years of prolonged enteral replication in an immunodeficient patient.

abstract：:Bacteriophage P2 integrase (Int) mediates site-specific recombination leading to integration or excision of the phage genome in or out of the bacterial chromosome. Int belongs to the large family of tyrosine recombinases that have two different DNA recognition motifs binding to the arm and core sites, respectively, wh...

journal_title：Virology

authors： Frumerie C,Sylwan L,Ahlgren-Berg A,Haggård-Ljungquist E

更新日期：2005-02-05 00:00:00

abstract：:Bovine papillomavirus type 4 (BPV-4) morphologically transforms primary bovine cells in vitro only in the presence of an activated ras gene. The transformed cells are capable of anchorage-independent growth, but are not immortal and are incapable of inducing tumors in nude mice, suggesting that other events are needed...

journal_title：Virology

authors： Pennie WD,Campo MS

更新日期：1992-10-01 00:00:00

abstract：:The quasispecies structure of nervous necrosis virus (NNV) was determined to investigate an outbreak of viral nervous necrosis disease at a barramundi (Lates calcarifer) hatchery. A traditional epidemiological investigation indicated horizontal transmission of infection between two cohorts of fish. However, variation ...

journal_title：Virology

authors： Hick P,Gore K,Whittington R

更新日期：2013-02-05 00:00:00

abstract：:Lactate dehydrogenase-elevating virus (LDV) is currently classified within the Togaviridae family. In an effort to obtain further information on the characteristics of this virus, we have begun to sequence the viral RNA genome and to map the virion structural protein genes. A sequence of 1064 nucleotides, which repres...

journal_title：Virology

authors： Godeny EK,Speicher DW,Brinton MA

更新日期：1990-08-01 00:00:00

abstract：:We have mapped the genome of lettuce necrotic yellows virus (LNYV), the type member of the genus cytorhabdovirus of the family Rhabdoviridae. We have cloned and sequenced all intergenic regions and the 3' leader and 5' trailer of the negative-sense, single-stranded RNA genome of LNYV. The LNYV genome appears to contai...

journal_title：Virology

authors： Wetzel T,Dietzgen RG,Dale JL

更新日期：1994-05-01 00:00:00

abstract：:We recently showed that E6 protein of human papillomavirus (HPV) 16, a mucosal high-risk α-PV type, can potentiate Wnt/β-catenin/TCF signaling. Here we investigated the transcriptional activities of E6 proteins of cutaneous HPV types from the β and α genera. Results from reporter-gene assays showed that similar to HPV...

journal_title：Virology

authors： Sominsky S,Shterzer N,Jackman A,Shapiro B,Yaniv A,Sherman L

更新日期：2017-09-01 00:00:00

abstract：:Adenovirus early region 1A (E1A) products are phosphorylated nuclear oncoproteins which appear to derive transforming activity largely through interactions with cellular proteins including the tumor suppressor p105/Rb-1 and cyclin A (p60cycA), a regulatory subunit associated with p34cdc2 and the related protein kinase...

journal_title：Virology

authors： Dumont DJ,Branton PE

更新日期：1992-07-01 00:00:00

abstract：:While several studies have shown a role for autophagy in the replication of dengue virus (DENV), these studies have been performed in directly infected cells. However, in severe cases of DENV infection the critical cell in the disease is believed to be monocytes which are poorly infected directly, but are highly susce...

journal_title：Virology

authors： Panyasrivanit M,Greenwood MP,Murphy D,Isidoro C,Auewarakul P,Smith DR

更新日期：2011-09-15 00:00:00

abstract：:We studied experimental canine oral papillomavirus (COPV) infection by in situ hybridization and immunohistochemistry of weekly biopsies. After 4 weeks, viral DNA in rete ridges suggested a keratinocyte stem cell target. Abundant viral DNA was seen in E4-positive cells only. E4 was predominantly cytoplasmic but also n...

journal_title：Virology

authors： Nicholls PK,Doorbar J,Moore RA,Peh W,Anderson DM,Stanley MA

更新日期：2001-05-25 00:00:00

abstract：:The genus Badnavirus is characterized by members that are genetically and serologically heterogeneous which presents challenges for their detection and characterization. The presence of integrated badnavirus-like sequences in some host species further complicates detection using PCR-based protocols. To address these c...

journal_title：Virology

authors： Sukal AC,Kidanemariam DB,Dale JL,Harding RM,James AP

更新日期：2019-03-01 00:00:00

abstract：:Edible vaccines that can be made widely available and easily administered could bring great benefit to the worldwide battle against pandemic viral infections. They can be used not only for the vaccination of humans and domesticated animals, but also for wild herds and live stock which are otherwise difficult to vaccin...

journal_title：Virology

authors： Lei H,Xu Y,Chen J,Wei X,Lam DM

更新日期：2010-11-25 00:00:00

abstract：:The majority of HIV-1 infections occur via sexual intercourse. Women are the most affected by the epidemic, particularly in developing countries, due to their socio-economic dependence on men and the fact that they are often victims of gender based sexual violence. Despite significant efforts that resulted in the redu...

journal_title：Virology

authors： Alexandre KB,Mufhandu HT,London GM,Chakauya E,Khati M

更新日期：2016-10-01 00:00:00

abstract：:Recently, the product of equine herpesvirus type 1 (EHV-1) ORF1, a homolog to HSV-1 pUL56, was shown to modulate MHC-I expression and innate immunity. Here, we investigated modulation of respiratory epithelial immunity by EHV-1 pUL56 and compared responses to those of PBMCs, which are important target cells that allow...

journal_title：Virology

authors： Soboll Hussey G,Ashton LV,Quintana AM,Van de Walle GR,Osterrieder N,Lunn DP

更新日期：2014-09-01 00:00:00

abstract：:Treatment of HeLa cells with human lymphoblastoid interferon (IFN-alpha) does not inhibit reovirus type 3 protein synthesis during virus infection. In contrast, reovirus translation is blocked by treatment of L cells with mouse IFN-alpha. The (2'-5')A synthetase activity is induced in HeLa cells by IFN-alpha treatment...

journal_title：Virology

authors： Feduchi E,Esteban M,Carrasco L

更新日期：1988-06-01 00:00:00

abstract：:The genome of the lytic Pseudomonas putida bacteriophage gh-1 is linear double-stranded DNA containing 37,359 bp with 216-bp direct terminal repeats. Like other members of the T7 group, the gh-1 genome contains regions of high homology to T7 interspersed with nonhomologous regions that contain small open reading frame...

journal_title：Virology

authors： Kovalyova IV,Kropinski AM

更新日期：2003-07-05 00:00:00

abstract：:A collection of TK+, ACV-resistant mutants of herpes simplex virus type 1 (HSV-1) has been derived using a selection system based on biochemically transformed cells. Evidence is presented suggesting that most of these mutants induce resistant DNA polymerase activities and are thus likely to express variant DNA polymer...

journal_title：Virology

authors： Larder BA,Darby G

更新日期：1985-10-30 00:00:00

abstract：:The transcription/replication activity of ribonucleoproteins derived from influenza A primary isolates of human (A/Paris/908/97) or avian origin (A/Mallard/Marquenterre/MZ237/83, A/Hong Kong/156/97) was compared upon reconstitution in mammalian or avian cells, using viral-like reporter RNAs synthesized under the contr...

journal_title：Virology

authors： Labadie K,Dos Santos Afonso E,Rameix-Welti MA,van der Werf S,Naffakh N

更新日期：2007-06-05 00:00:00

abstract：:Natural antibodies to gp41 inhibit HIV-1 replication through the recognition of two different regions, corresponding to the leucine zipper motif in the HR1 alpha-helix and to another motif within HR2 region, hosting 2F5 and 4E10 epitope. This study aimed at reproducing such protective responses through VLP vaccination...

journal_title：Virology

authors： Pastori C,Tudor D,Diomede L,Drillet AS,Jegerlehner A,Röhn TA,Bomsel M,Lopalco L

更新日期：2012-09-15 00:00:00

abstract：:Alphaherpesviruses comprise closely related viruses of man and animal, including herpes simplex virus, varicella-zoster virus and pseudorabies virus (PRV). Here, using methyl-beta-cyclodextrin and fluorescently tagged PRV, we directly show that depletion of cholesterol from the plasma membrane of host cells significan...

journal_title：Virology

authors： Desplanques AS,Nauwynck HJ,Vercauteren D,Geens T,Favoreel HW

更新日期：2008-07-05 00:00:00

abstract：:Ubiquitin C-terminal Hydrolase L1 (UCH-L1) has oncogenic properties and is highly expressed during malignancies. We recently documented that Epstein-Barr virus (EBV) infection induces uch-l1 expression. Here we show that Kaposi's Sarcoma-associated herpesvirus (KSHV) infection induced UCH-L1 expression, via cooperatio...

journal_title：Virology

authors： Bentz GL,Bheda-Malge A,Wang L,Shackelford J,Damania B,Pagano JS

更新日期：2014-01-05 00:00:00

abstract：:The surface of the mature dengue virus (DENV) particle consists of 90 envelope (E) protein dimers that mediate both receptor binding and fusion. The E protein ectodomain can be divided into three structural domains designated ED1, ED2, and ED3, of which ED3 contains the critical and dominant virus-specific neutralizat...

journal_title：Virology

authors： Gromowski GD,Barrett AD

更新日期：2007-09-30 00:00:00

abstract：:The synthesis and processing of the nucleocapsid protein (pp60) of the JHM strain of murine coronaviruses were examined. Pulse-chase experiments showed that pp60 was synthesized initially as a protein of approximately 57,000 in molecular weight (p57). Immunoprecipitation using mouse anti-JHMV antiserum indicated that ...

journal_title：Virology

authors： Stohlman SA,Fleming JO,Patton CD,Lai MM

更新日期：1983-10-30 00:00:00

abstract：:We have investigated the effect of a monoclonal antibody on influenza virus release and the cell surface expression of M2, comparing virus strains which were observed previously to be sensitive (A/Udorn) or resistant (A/WSN and A/Udorn variants) to growth inhibition by M2 antibody 14C2. Incubation of A/Udorn virus-inf...

journal_title：Virology

authors： Hughey PG,Roberts PC,Holsinger LJ,Zebedee SL,Lamb RA,Compans RW

更新日期：1995-10-01 00:00:00

abstract：:At high concentrations, several monoclonal antibodies to the G1 glycoprotein of La Crosse (LAC) virus aggregated the virus. To determine whether this accounted for the neutralization, the monoclonal antibodies were digested to make Fab fragments. With one exception, each monovalent antibody neutralized LAC virus to th...

journal_title：Virology

authors： Kingsford L,Boucquey KH,Cardoso TP

更新日期：1991-02-01 00:00:00

abstract：:The nucleotide sequence of the infectious laryngotracheitis virus (ILTV) gene encoding the 205K complex glycoprotein (gp205) was determined. The gene is contained within a 3-kb EcoRI restriction fragment mapping at approximately map coordinates 0.23 to 0.25 in the UL region of the ILTV genome and is transcribed from r...

journal_title：Virology

authors： Kongsuwan K,Prideaux CT,Johnson MA,Sheppard M,Fahey KJ

更新日期：1991-09-01 00:00:00

abstract：:The nucleotide sequence of gene 6 encoding the rotavirus major capsid protein VP6 of EDIM strain (EW) was determined and compared to that of 20 previously reported strains with known subgroup specificities. Multiple alignments of amino acid sequences exhibited a high level of sequence conservation (87 to 99.2%). Site-...

journal_title：Virology

authors： Tang B,Gilbert JM,Matsui SM,Greenberg HB

更新日期：1997-10-13 00:00:00

abstract：:Like their animal-infecting counterparts, plant bunyaviruses use capped RNA leaders cleaved from host cellular mRNAs to prime viral genome transcription in a process called cap-snatching, but in vivo systems to investigate the details of this process are lacking for them. Here, we report that Rice stripe tenuivirus (R...

journal_title：Virology

authors： Lin W,Wu R,Qiu P,Jing Jin,Yang Y,Wang J,Lin Z,Zhang J,Wu Z,Du Z

更新日期：2020-01-02 00:00:00

abstract：:The mutations in two DNA-negative ts mutants of herpes simplex virus type 1 (HSV-1), tsK13 and tsM19, have been previously mapped to a 2.0-kb fragment (coordinates 0.095-0.108) at the left end of the genome (S. Weller, D. Aschman, W. Sacks, D. Coen, and P. Schaffer, 1983, Virology 130, 290-305). Sequence analysis of t...

journal_title：Virology

authors： Zhu L,Weller SK

更新日期：1988-10-01 00:00:00

abstract：:An infectious and full-length molecular clone of genomic human spumaretrovirus (HSRV) DNA was constructed. The infectivity of the pHSRV13 clone was demonstrated after transfection into susceptible cells by passage of HSRV-specific cytopathic effects as a cell-free culture supernatant, by electron microscopy of HSRV pa...

journal_title：Virology

authors： Löchelt M,Zentgraf H,Flügel RM

更新日期：1991-09-01 00:00:00

abstract：:The vaccinia virus temperature-sensitive mutations Cts6 and Cts9 were mapped by marker rescue and DNA sequencing to the A28 gene. Cts6 and Cts9 contain an identical 2-bp deletion truncating the A28 protein and removing the fourth conserved cysteine near the C-terminus. Cts9 mutant virions produced at 40 degrees C were...

journal_title：Virology

authors： Turner PC,Dilling BP,Prins C,Cresawn SG,Moyer RW,Condit RC

更新日期：2007-09-15 00:00:00