Loss of HIV-specific memory B-cells as a potential mechanism for the dysfunction of the humoral immune response against HIV.

abstract：:Enterovirus 71 (EV71) is a major cause of hand-foot-and-mouth disease. EV71 infection occasionally associates with severe neurological sequelae such as brainstem encephalitis or poliovirus-like paralysis. We demonstrated that mouse-adapted strain increases infectivity, resulting in higher cytotoxicity of neuron cells ...

journal_title：Virology

authors： Huang SW,Wang YF,Yu CK,Su IJ,Wang JR

更新日期：2012-01-05 00:00:00

abstract：:The gene encoding the VP8* trypsin-cleavage product of the VP4 protein of porcine rotavirus strain A34 was sequenced, and the predicted amino acid (aa) sequence was compared to the homologous region of all known P genotypes. The aa sequence of the VP8* of strain A34 shared low identity, ranging from 39% (bovine strain...

journal_title：Virology

authors： Liprandi F,Gerder M,Bastidas Z,López JA,Pujol FH,Ludert JE,Joelsson DB,Ciarlet M

更新日期：2003-10-25 00:00:00

abstract：:The minimal 5' initiation of assembly sequence for papaya mosaic virus (PMV) has been determined by the generation of successive 3' deletion clones from a full-length cDNA copy of the PMV genome followed by in vitro assembly of RNA transcripts. Sequences closest to the 5' terminus were cloned into plasmid vectors with...

journal_title：Virology

authors： Sit TL,Leclerc D,AbouHaidar MG

更新日期：1994-02-15 00:00:00

abstract：:Unusual Plum pox virus (PPV) isolates (named Tat isolates) were discovered on sour cherry (Prunus cerasus) in Russia. They failed to be recognized by RT-PCR using commonly employed primers specific to the strains C or CR (the only ones that proved able to infect sour cherry) as well as to the strains M and W. Some of ...

journal_title：Virology

authors： Chirkov S,Ivanov P,Sheveleva A,Zakubanskiy A,Osipov G

更新日期：2017-02-01 00:00:00

abstract：:Information about the basic biological properties of human rhinovirus-C (HRV-C) viruses is lacking due to difficulties with culturing these viruses. Our objective was to develop a cell culture system to grow HRV-C. Epithelial cells from human sinuses (HSEC) were differentiated at air-liquid interface (ALI). Differenti...

journal_title：Virology

authors： Ashraf S,Brockman-Schneider R,Bochkov YA,Pasic TR,Gern JE

更新日期：2013-02-05 00:00:00

abstract：:Herpes simplex virus 1 glycoprotein B (gB) is one of 10 glycoproteins in the virion envelope and in the membranes of infected cells. It is required for infection of cells in culture and functions in penetration of the cell by fusing the virion envelope with the plasma membrane. In studies to map the functional domains...

journal_title：Virology

authors： Navarro D,Paz P,Pereira L

更新日期：1992-01-01 00:00:00

abstract：:The spike glycoprotein (G protein) of rabies virus (CVS strain) expressed in HeLa cells from cloned cDNA mediated membrane fusion after exposure to pHs of 6.1 or below. Chemical crosslinking showed that the rabies G protein, like the vesicular stomatitis virus (VSV) G protein, could be crosslinked to dimers and trimer...

journal_title：Virology

authors： Whitt MA,Buonocore L,Prehaud C,Rose JK

更新日期：1991-12-01 00:00:00

abstract：:RNA analysis by nondenaturing polyacrylamide gel electrophoresis and Northern blot hybridization of avocado chloroplasts purified from protoplasts of leaves infected by avocado sunblotch viroid (ASBVd) revealed the main ASBVd-specific bands found previously in preparations of total leaf RNA: the monomeric, dimeric and...

journal_title：Virology

authors： Navarro JA,Darós JA,Flores R

更新日期：1999-01-05 00:00:00

abstract：:Influenza antiviral drugs that use protein inhibitors can lose their efficacy as resistant strains emerge. As an alternative strategy, we investigated the use of small interfering RNA molecules (siRNAs) by characterizing three siRNAs (M747, M776 and M832) targeting the influenza matrix 2 gene and three (NS570, NS595 a...

journal_title：Virology

authors： McMillen CM,Beezhold DH,Blachere FM,Othumpangat S,Kashon ML,Noti JD

更新日期：2016-10-01 00:00:00

abstract：:The immunogenicity of capsomeres of human papillomavirus type 33 was evaluated in a dose-response analysis. Capsomeres were obtained free of capsids by expression of L1 carrying the single point mutation C427S. Neutralizing antibodies were detected using an in vitro pseudoinfection assay. Capsomeres induced type-speci...

journal_title：Virology

authors： Fligge C,Giroglou T,Streeck RE,Sapp M

更新日期：2001-05-10 00:00:00

abstract：:Of five globally important VP7 (G) serotypes (G1-4 and 9) of group A rotaviruses (the single most important etiologic agents of infantile diarrhea worldwide), G9 continues to attract considerable attention because of its unique natural history. Serotype G9 rotavirus was isolated from a child with diarrhea first in the...

journal_title：Virology

authors： Hoshino Y,Honma S,Jones RW,Ross J,Santos N,Gentsch JR,Kapikian AZ,Hesse RA

更新日期：2005-02-05 00:00:00

abstract：:The synthesis of linear duplex replicative structures (monomers, head-to-head, and tail-to-tail dimers) is an important hallmark of the productive phase of the adeno-associated virus (AAV) life cycle. These structures are generated by a strand-displacement replication mechanism and believed to be a reservoir for singl...

journal_title：Virology

authors： Musatov SA,Scully TA,Dudus L,Fisher KJ

更新日期：2000-09-30 00:00:00

abstract：:The human APOBEC3G protein exhibits broad antiretroviral activity against a variety of retroviruses. It is packaged into viral particles and executes its antiviral function in the target cell. The packaging of APOBEC3G into different viral particles requires a mechanism that confers this promiscuity. Here, APOBEC3G in...

journal_title：Virology

authors： Kremer M,Bittner A,Schnierle BS

更新日期：2005-06-20 00:00:00

abstract：:Nucleos(t)ide analogues that inhibit hepatitis B virus (HBV) DNA replication are typically used as monotherapy for chronically infected patients. Treatment with a nucleos(t)ide analogue eliminates most HBV DNA replication intermediates and produces a gradual decline in levels of covalently closed circular DNA (cccDNA)...

journal_title：Virology

authors： Reaiche-Miller GY,Thorpe M,Low HC,Qiao Q,Scougall CA,Mason WS,Litwin S,Jilbert AR

更新日期：2013-11-01 00:00:00

abstract：:To address the mechanisms of host-virus adaptation and pathogenesis of lentiviral infections, we compared the evolution of the same isolate of simian immunodeficiency virus (SIVsmm9) in two different situations: nonpathogenic infection of its natural host, the sooty mangabey, and AIDS-inducing infection of a new host,...

journal_title：Virology

authors： Courgnaud V,Saurin W,Villinger F,Sonigo P

更新日期：1998-07-20 00:00:00

abstract：:Encephalitis is a rare, but serious complication from vaccination against smallpox using replication competent strains of vaccinia virus. In this report we describe mutants of vaccinia virus, containing N-terminal deletions of the vaccinia virus interferon resistance gene, E3L, that are attenuated for neuropathogenesi...

journal_title：Virology

authors： Brandt T,Heck MC,Vijaysri S,Jentarra GM,Cameron JM,Jacobs BL

更新日期：2005-03-15 00:00:00

abstract：:The human apolipoprotein B mRNA editing enzyme catalytic peptide-like 3 (APOBEC3; A3) family of proteins (A3A-H) are known to restrict various retroviruses and retroelements, but the full complement of rhesus macaque A3 proteins remains unclear. We report the isolation and characterization of the hA3A homologue from r...

journal_title：Virology

authors： Schmitt K,Guo K,Algaier M,Ruiz A,Cheng F,Qiu J,Wissing S,Santiago ML,Stephens EB

更新日期：2011-10-10 00:00:00

abstract：:Since SARS-CoV-2 spreads rapidly around the world, data have been needed on the natural fluctuation of viral load and clinical indicators associated with it. We measured and compared viral loads of SARS-CoV-2 from pharyngeal swab, IgM anti-SARS-CoV-2, CRP and SAA from serum of 114 COVID-19 patients on admission. Posit...

journal_title：Virology

authors： Shi F,Wu T,Zhu X,Ge Y,Zeng X,Chi Y,Du X,Zhu L,Zhu F,Zhu B,Cui L,Wu B

更新日期：2020-07-01 00:00:00

abstract：:We have investigated a novel strategy for coexpressing two genes from a retroviral vector. The 5' nontranslated leader region of at least some picornavirus RNAs contains a sequence that can act as an internal ribosome entry site allowing initiation of translation at a downstream AUG codon in a 5' cap-independent manne...

journal_title：Virology

authors： Koo HM,Brown AM,Kaufman RJ,Prorock CM,Ron Y,Dougherty JP

更新日期：1992-02-01 00:00:00

abstract：:Bluetongue virus (BTV) VP1 protein, a component of the viral RNA-directed RNA polymerase, but not the VP4 or VP6 proteins, was specifically incorporated into baculovirus expressed BTV core-like particles (composed of VP3 and VP7) and BTV virus-like particles (composed of VP2, VP3, VP5, and VP7). The VP1 protein has be...

journal_title：Virology

authors： Loudon PT,Roy P

更新日期：1991-02-01 00:00:00

abstract：:Felis catus papillomavirus type 2 (FcaPV2) DNA is found in feline cutaneous squamous cell carcinomas (SCCs); however, its biological properties are still uncharacterized. In this study, we successfully expressed FcaPV2 E6 and E7 putative oncogenes in feline epithelial cells and demonstrated that FcaPV2 E6 binds to p53...

journal_title：Virology

authors： Altamura G,Corteggio A,Pacini L,Conte A,Pierantoni GM,Tommasino M,Accardi R,Borzacchiello G

更新日期：2016-09-01 00:00:00

abstract：:Autographa californica multiple nucleopolyhedrovirus (AcMNPV) ac142 is a baculovirus core gene and encodes a protein previously shown to associate with occlusion-derived virus (ODV). To determine its role in the baculovirus life cycle, we used the AcMNPV bacmid system to generate an ac142 deletion virus (AcBAC(ac142KO...

journal_title：Virology

authors： McCarthy CB,Dai X,Donly C,Theilmann DA

更新日期：2008-03-15 00:00:00

abstract：:Exosomes are membranous extracellular nanovesicles secreted by diverse cell types. Exosomes from healthy human semen have been shown to inhibit HIV-1 replication and to impair progeny virus infectivity. In this study, we examined the ability of healthy human semen exosomes to restrict HIV-1 and LP-BM5 murine AIDS viru...

journal_title：Virology

authors： Madison MN,Jones PH,Okeoma CM

更新日期：2015-08-01 00:00:00

abstract：:Within immunocompromised populations, the JC polyomavirus is the cause of the often-fatal disease Progressive Multifocal Leukoencephalopathy (PML). JC virus encodes a protein, termed T-antigen (T-ag), which is essential for its replication and pathogenicity. Previous studies of JCV T-ag have, in general, used antibodi...

journal_title：Virology

authors： Grubman SA,Shin J,Phelan PJ,Gong A,Can H,Dilworth R,Kini SK,Gagnon D,Archambault J,Meinke G,Bohm A,Jefferson DM,Bullock PA

更新日期：2016-10-01 00:00:00

abstract：:Insertion of nucleotide sequences encoding "tags" that can be expressed in specific viral proteins during an infection is a useful strategy for purifying viral proteins and their functional complexes from infected cells and/or for visualizing the dynamics of their subcellular location over time. To identify regions in...

journal_title：Virology

authors： Teterina NL,Lauber C,Jensen KS,Levenson EA,Gorbalenya AE,Ehrenfeld E

更新日期：2011-01-05 00:00:00

abstract：:Coinfection of tobacco plants with potato virus X (PVX) and any of several members of the potyvirus group causes a synergistic disease characterized by a dramatic increase in symptom severity correlated with a 3- to 10-fold increase in the accumulation of PVX in the first systemically infected leaves. We have recently...

journal_title：Virology

authors： Shi XM,Miller H,Verchot J,Carrington JC,Vance VB

更新日期：1997-04-28 00:00:00

abstract：:Infectious Bursal Disease Virus (IBDV) causes a highly relevant poultry disease that affects young chickens causing, among other effects, immunosuppression. IBDV is a bi-segmented double stranded RNA virus. The smaller ORF of larger RNA segment encodes VP5, a 17-kDa non-structural protein. Although it is an important ...

journal_title：Virology

authors： Carballeda JM,Maroniche G,Lucero MS,Richetta M,Gómez E,Chimeno Zoth S,Berinstein A

更新日期：2015-09-01 00:00:00

abstract：:The 5' end of the subgenomic RNA of rubella virus was determined by primer extension. The Maxam-Gilbert sequence ladder of the primer extension product contained a determinable sequence which was colinear with the complement of the sequence of the genomic RNA through nucleotide 3325 from the 3' end of the genomic RNA ...

journal_title：Virology

authors： Frey TK,Marr LD,Sanchez A,Simmons RB

更新日期：1989-01-01 00:00:00

abstract：:The location of the RNA start point of in vivo Q-activated late gene RNA of bacteriophage lambda has been determined to be identical to the start point of in vitro 6 S RNA. The 6 S RNA is made early in infection and is efficiently antiterminated by Q. Two RNase III cut sites are located within Q-dependent RNA sequence...

journal_title：Virology

authors： Daniels DL,Subbarao MN,Blattner FR,Lozeron HA

更新日期：1988-12-01 00:00:00

abstract：:The alphaherpesviruses establish latent infections in sensory neuronal cells, during which a number of latency-associated RNA transcripts (LATs) are produced. The reasons for the production of the LATs, however, and the mechanism by which the LAT region of the genome remains active during latency are unknown. Here we ...

journal_title：Virology

authors： Coffin RS,Howard MK,Latchman DS

更新日期：1995-06-01 00:00:00