Abstract:
:Equine infectious anemia virus (EIAV) is a lentivirus that causes persistent infections in horses. We hypothesized that high-avidity CTL specific for nonvariable epitopes might be associated with low viral load and minimal disease in EIAV-infected horses. To test this hypothesis, memory CTL (CTLm) responses were analyzed in two infected horses with high plasma viral loads and recurrent disease (progressors), and in two infected horses with low-to-undetectable viral loads and mild disease (nonprogressors). High-avidity CTLm in one progressor recognized an envelope gp90 epitope, and the data documented for the first time in EIAV that viral variation led to CTL escape. Each of the nonprogressors had high-to-moderate avidity CTLm directed against epitopes within Rev, including the nuclear export and nuclear localization domains. These results suggested that the epitope specificity of high- and moderate-avidity CTLm was an important determinant for disease outcome in the EIAV-infected horses examined.
journal_name
Virologyjournal_title
Virologyauthors
Mealey RH,Zhang B,Leib SR,Littke MH,McGuire TCdoi
10.1016/s0042-6822(03)00344-1subject
Has Abstractpub_date
2003-09-01 00:00:00pages
537-52issue
2eissn
0042-6822issn
1096-0341pii
S0042682203003441journal_volume
313pub_type
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