当前位置： SCI文献检索 > VIROLOGY期刊下所有文献 > Sequence comparison of JSRV with endogenous proviruses: envelope genotypes and a novel ORF with similarity to a G-protein-coupled receptor.

Sequence comparison of JSRV with endogenous proviruses: envelope genotypes and a novel ORF with similarity to a G-protein-coupled receptor.

Abstract：

:Ovine pulmonary carcinoma, a contagious lung cancer of sheep, is caused by the oncogenic jaagsiekte sheep retrovirus (JSRV) that is closely related to a family of endogenous sheep retroviral sequences (ESRVs). By using exogenous virus-specific U3 oligonucleotide primers, the entire JSRV proviral genome or its 3' part was amplified from tumor DNA. Analysis of these proviral sequences revealed a novel open reading frame (ORF) within the pol coding region, designated ORF X, which was well conserved in ESRV and JSRV sequences. Deduced amino acids of ORF X showed similarity to a portion of the mammalian adenosine receptor subtype 3, a member of the G-protein-coupled receptor family. Comparison of deduced env amino acids of six JSRV strains from three continents identified 15 residues that defined two distinct genotypes of JSRVs. Sequence analysis identified two highly variable regions between JSRV and ESRV in the transmembrane domain of env (TM) and the 3' unique sequence (U3) of the long terminal repeat, from which JSRV-specific DNA probes were derived. By using these DNA probes in Southern hybridization, for the first time we successfully identified JSRV proviral sequences in tumor genomic DNA in the presence of multiple ESRV loci, validating the use of exogenous virus-specific DNA probes in the analysis of oncogenic proviral integration sites and identification of integrated exogenous proviral sequences.

journal_name

Virology

journal_title

Virology

authors

Bai J,Bishop JV,Carlson JO,DeMartini JC

doi

10.1006/viro.1999.9728

subject

Has Abstract

pub_date

1999-06-05 00:00:00

pages

333-43

issue

2

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(99)99728-3

journal_volume

258

pub_type

杂志文章

相关文献

VIROLOGY文献大全
  • Genotype-specific synthesis and secretion of spliced hepatitis B virus genomes in hepatoma cells.

    abstract：:Hepatitis B virus-infected patients frequently have viral particles with DNA derived from differently spliced RNA. Which factors influence the synthesis of these splice variants is unclear. We analysed the type of splice variants produced from different genotypes and determined whether they are secreted as efficiently...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2000.0331

    authors： Sommer G,van Bömmel F,Will H

    更新日期：2000-06-05 00:00:00

  • Genomic diversity and interspecies host infection of alpha12 Macaca fascicularis papillomaviruses (MfPVs).

    abstract：:Alpha human papillomaviruses (HPVs) are among the most common sexually transmitted agents of which a subset causes cervical neoplasia and cancer in humans. Alpha-PVs have also been identified in non-human primates although few studies have systematically characterized such types. We cloned and characterized 10 distinc...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2009.07.012

    authors： Chen Z,van Doorslaer K,DeSalle R,Wood CE,Kaplan JR,Wagner JD,Burk RD

    更新日期：2009-10-25 00:00:00

  • Characterization of the hepatitis C virus RNA replication complex associated with lipid rafts.

    abstract：:The mechanism and machinery of hepatitis C virus (HCV) RNA replication are still poorly characterized. Our previous study has shown that HCV RNA synthesis occurs on a lipid raft membrane structure [J. Virol. 77 (2003) 77 4160]. In this study, we further characterized these replication complexes (RCs) in Huh-7 cells th...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2004.03.034

    authors： Aizaki H,Lee KJ,Sung VM,Ishiko H,Lai MM

    更新日期：2004-07-01 00:00:00

  • Geographic distribution and evolution of Ross River virus in Australia and the Pacific Islands.

    abstract：:We examined the molecular epidemiology and evolution of Ross River (RR) virus in Australia and the Pacific Islands. Nucleotide sequences of the E2 and E3 genes of five RR virus strains revealed remarkable conservation between 1959 and 1989 with a maximum divergence of only 3.3%. Sequence data from a 505-base pair frag...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1995.1449

    authors： Sammels LM,Coelen RJ,Lindsay MD,Mackenzie JS

    更新日期：1995-09-10 00:00:00

  • Subcellular distribution of the foot-and-mouth disease virus 3A protein in cells infected with viruses encoding wild-type and bovine-attenuated forms of 3A.

    abstract：:Picornavirus infection induces the proliferation and rearrangement of intracellular membranes in response to the synthesis of nonstructural proteins, including 3A. We have previously shown that changes in 3A are associated with the inability of a Taiwanese strain of foot-and-mouth disease virus (FMDV) (OTai) to grow i...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2001.1035

    authors： O'Donnell VK,Pacheco JM,Henry TM,Mason PW

    更新日期：2001-08-15 00:00:00

  • Induction of the SOS response by bacteriophage lytic development in Salmonella enterica.

    abstract：:Infection of Salmonella enterica with lytic mutants of either P22 or SE1 bacteriophages triggers the expression of its DNA damage-inducible SOS response through a lexA-dependent pathway. This induction of the SOS system strictly requires the presence of the bacteriophage kil gene. Accordingly, plasmid overexpression o...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2006.04.001

    authors： Campoy S,Hervàs A,Busquets N,Erill I,Teixidó L,Barbé J

    更新日期：2006-08-01 00:00:00

  • The V protein of human parainfluenza virus type 2 promotes RhoA-induced filamentous actin formation.

    abstract：:We previously demonstrated that human parainfluenza virus type 2 (hPIV-2) induces RhoA activation, which promotes its growth. RhoA controls the equilibrium between globular and filamentous actin (F-actin). We found that F-actin formation is induced by wild type (wt) hPIV-2 infection, and that inhibition of F-actin for...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2018.08.015

    authors： Ohta K,Matsumoto Y,Yumine N,Nishio M

    更新日期：2018-11-01 00:00:00

  • A major internal initiation site for the in vitro translation of the adenovirus DNA polymerase.

    abstract：:An open reading frame which encodes at least 90% of the adenovirus type 2 DNA polymerase gene was cloned behind the SP6 promoter and transcribed in vitro using the SP6 RNA polymerase. The resultant RNA was translated in a rabbit reticulocyte cell free system. In addition to the translation of a 120-kDa protein corresp...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(86)90181-9

    authors： Hassin D,Korn R,Horwitz MS

    更新日期：1986-11-01 00:00:00

  • Porcine sapelovirus enters PK-15 cells via caveolae-dependent endocytosis and requires Rab7 and Rab11.

    abstract：:To comprehensively understand the endocytosis of Sapelovirus A (PSV) entry into PK-15 cells, we studied PSV infection in the context of cell perturbations through drug inhibition, siRNA silencing and overexpression of dominant negative (DN) mutants. We showed here that PSV infection of PK-15 cells was unaffected by pr...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2019.01.009

    authors： Zhao T,Cui L,Yu X,Zhang Z,Shen X,Hua X

    更新日期：2019-03-01 00:00:00

  • Induction of circular episomes during rescue and replication of adeno-associated virus in experimental models of virus latency.

    abstract：:The synthesis of linear duplex replicative structures (monomers, head-to-head, and tail-to-tail dimers) is an important hallmark of the productive phase of the adeno-associated virus (AAV) life cycle. These structures are generated by a strand-displacement replication mechanism and believed to be a reservoir for singl...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2000.0504

    authors： Musatov SA,Scully TA,Dudus L,Fisher KJ

    更新日期：2000-09-30 00:00:00

  • Role of the Drosophila genome in Sigma virus multiplication. I. Role of the ret(2)P gene; selection of host-adapted mutants at the nonpermissive allele Pp.

    abstract：:The allele Pp of gene ref(2)P of Drosophila melanogaster is known to inhibit the multiplication of certain strains of Sigma virus. From a viral strain for which the allele PP of ref(2)P is nonpermissive, host adapted (haP) mutants were selected after mutagenesis in vivo. Mutagenized virus was extracted from infected f...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(81)90227-0

    authors： Contamine D

    更新日期：1981-10-31 00:00:00

  • Oxygen tension level and human viral infections.

    abstract：:The role of oxygen tension level is a well-known phenomenon that has been studied in oncology and radiotherapy since about 60 years. Oxygen tension may inhibit or stimulate propagation of viruses in vitro as well as in vivo. In turn modulating oxygen metabolism may constitute a novel approach to treat viral infections...

    journal_title：Virology

    pub_type： 杂志文章,评审

    doi：10.1016/j.virol.2013.06.018

    authors： Morinet F,Casetti L,François JH,Capron C,Pillet S

    更新日期：2013-09-01 00:00:00

  • Analysis of the autophosphorylation activity of transformation defective mutants of avian erythroblastosis virus.

    abstract：:The v-erb B protein of avian erythroblastosis virus (AEV) possesses an associated protein kinase activity in vitro. Analysis of temperature-sensitive mutants, and nonconditional host range mutants of AEV demonstrated that there was no simple correlation between this autophosphorylation activity and the transformation ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(86)90287-4

    authors： Hayman MJ,Kitchener G,Knight J,McMahon J,Watson R,Beug H

    更新日期：1986-04-15 00:00:00

  • Enhanced neutralization of La Crosse virus by the binding of specific pairs of monoclonal antibodies to the G1 glycoprotein.

    abstract：:Monoclonal antibodies specific for eight antigenic sites on the G1 glycoprotein of La Crosse virus were studied in a kinetics of neutralization assay. When examined at the same protein concentration, there were differences in the rates and degree of neutralization induced by these antibodies. The maximum amount of neu...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(84)90163-6

    authors： Kingsford L

    更新日期：1984-07-30 00:00:00

  • Modeling-based characterization of the elicitor function of amino acid 461 of Cucumber mosaic virus 1a protein in the hypersensitive response.

    abstract：:The Ns strain of Cucumber mosaic virus (CMV) induces hypersensitive response (HR) on Nicotiana tabacum cv. Xanthi-nc and on Nicotiana glutinosa. The genetic determinant of the HR induction was localized earlier to amino acid 461 of the 1a protein. The 3D structure of the 1a protein is still unknown and building a homo...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2006.08.014

    authors： Salánki K,Gellért A,Náray-Szabó G,Balázs E

    更新日期：2007-02-05 00:00:00

  • Analysis of the SH3-binding region of HIV-1 nef: partial functional defects introduced by mutations in the polyproline helix and the hydrophobic pocket.

    abstract：:An SH3-binding domain within the Nef protein of primate lentiviruses has been reported to be important to viral replication and infectivity and dispensable for CD4 downregulation, but its precise role remains unclear. This study investigates the effects of mutations in both the polyproline helix and in the hydrophobic...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1999.9897

    authors： Craig HM,Pandori MW,Riggs NL,Richman DD,Guatelli JC

    更新日期：1999-09-15 00:00:00

  • Integrin alpha2beta1 mediates the cell attachment of the rotavirus neuraminidase-resistant variant nar3.

    abstract：:It was previously reported that integrins alpha2beta1, alpha4beta1, and alphaXbeta2 are involved in rotavirus cell infection. In this work we studied the role of integrin subunits alpha2, alpha4, and beta2 on the attachment of rotaviruses RRV and nar3 to MA104 cells. Integrin alpha2beta1 was found to serve as the bind...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2000.0660

    authors： Zárate S,Espinosa R,Romero P,Guerrero CA,Arias CF,López S

    更新日期：2000-12-05 00:00:00

  • Essential role of the unordered VP2 n-terminal domain of the parvovirus MVM capsid in nuclear assembly and endosomal enlargement of the virion fivefold channel for cell entry.

    abstract：:The unordered N-termini of parvovirus capsid proteins (Nt) are translocated through a channel at the icosahedral five-fold axis to serve for virus traffick. Heterologous peptides were genetically inserted at the Nt of MVM to study their functional tolerance to manipulations. Insertion of a 5T4-single-chain antibody at...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2012.05.025

    authors： Sánchez-Martínez C,Grueso E,Carroll M,Rommelaere J,Almendral JM

    更新日期：2012-10-10 00:00:00

  • Chimeric constructs between two hepatitis B virus genomes confirm transcriptional impact of core promoter mutations and reveal multiple effects of core gene mutations.

    abstract：:Hepatitis B virus (HBV) clone 4B replicated much more efficiently than clone 2A of the same genotype. Introduction of its T1753C, A1762T, G1764A, and C1766T core promoter mutations into the 2A genome greatly enhanced genome replication and suppressed HBeAg expression. Here we show that these effects are mediated by tr...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2009.03.002

    authors： Tsai A,Kawai S,Kwei K,Gewaily D,Hutter A,Tong DR,Li J,Wands JR,Tong S

    更新日期：2009-05-10 00:00:00

  • Sequestration of human cytomegalovirus by human renal and mammary epithelial cells.

    abstract：:Urine and breast milk represent the main routes of human cytomegalovirus (HCMV) transmission but the contribution of renal and mammary epithelial cells to viral excretion remains unclear. We observed that kidney and mammary epithelial cells were permissive to HCMV infection and expressed immediate early, early and lat...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2014.04.032

    authors： Twite N,Andrei G,Kummert C,Donner C,Perez-Morga D,De Vos R,Snoeck R,Marchant A

    更新日期：2014-07-01 00:00:00

  • Effects of terminal deletion mutations on function of the movement protein of tobacco mosaic virus.

    abstract：:A series of carboxy- and amino-terminal deletion mutations in the movement protein (MP) gene of tobacco mosaic virus (TMV) were ligated into a cloned TMV cDNA deleted for the endogenous MP gene. RNA transcripts were produced in vitro from clones carrying the various mutated MP genes. The effect of the deletion mutatio...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(92)90452-u

    authors： Gafny R,Lapidot M,Berna A,Holt CA,Deom CM,Beachy RN

    更新日期：1992-04-01 00:00:00

  • Hepatitis B virus polymerase suppresses translation of pregenomic RNA via a mechanism involving its interaction with 5' stem-loop structure.

    abstract：:The pregenomic RNA (pgRNA) of hepadnaviruses serves a dual role: as mRNA for the core (C) and polymerase (P) synthesis and as an RNA template for viral genome replication. A question arises as to how these two roles are regulated. We hypothesized that the P protein could suppress translation of the pgRNA via its inter...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2007.11.010

    authors： Ryu DK,Kim S,Ryu WS

    更新日期：2008-03-30 00:00:00

  • Neutralizing monoclonal antibodies to human immunodeficiency virus type 1 do not inhibit viral transcytosis through mucosal epithelial cells.

    abstract：:HIV-1 transcytosis has been proposed as a potential mechanism allowing the virus to cross the epithelium during mucosal transmission. Epitopes of the HIV-1 envelope involved in this process have not been identified yet. Here, we assessed a large panel of HIV neutralizing antibodies recognizing well-characterized epito...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2007.09.006

    authors： Chomont N,Hocini H,Gody JC,Bouhlal H,Becquart P,Krief-Bouillet C,Kazatchkine M,Bélec L

    更新日期：2008-01-20 00:00:00

  • RNA segment 5 of broadhaven virus, a tick-borne orbivirus, shows sequence homology with segment 5 of bluetongue virus.

    abstract：:The sequence of Broadhaven (BRD) virus segment 5, the major genetic determinant of serotype, is 1658 nucleotides in length and contains a single open reading frame (ORF) having the coding capacity for a protein of Mr 52.5K. Comparison of the ORF of segment 5 of BRD virus with published sequences of bluetongue virus (B...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(90)90320-q

    authors： Moss SR,Fukusho A,Nuttall PA

    更新日期：1990-11-01 00:00:00

  • Lineage diversification of pigeon paramyxovirus effect re-emergence potential in chickens.

    abstract：:Genotype VI-paramyxovirus (GVI-PMV1) is a major cause of epidemic Newcastle-like disease in Columbiformes. This genotype of avian paramyxovirus type 1 has diversified rapidly since its introduction into the US in 1982 resulting in two extant lineages, which have different population growth properties. Although some GV...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2014.06.007

    authors： Chong YL,Kim O,Poss M

    更新日期：2014-08-01 00:00:00

  • Viruses and the autophagy pathway.

    abstract：:Studies of the cellular autophagy pathway have exploded over the past twenty years. Now appreciated as a constitutive degradative mechanism that promotes cellular homeostasis, autophagy is also required for a variety of developmental processes, cellular stress responses, and immune pathways. Autophagy certainly acts a...

    journal_title：Virology

    pub_type： 杂志文章,评审

    doi：10.1016/j.virol.2015.03.042

    authors： Jackson WT

    更新日期：2015-05-01 00:00:00

  • Upstream binding factor inhibits herpes simplex virus replication.

    abstract：:Herpes simplex virus 1 (HSV-1) infection induces changes to the host cell nucleus including relocalization of the cellular protein Upstream Binding Factor (UBF) from the nucleolus to viral replication compartments (VRCs). Herein, we tested the hypothesis that UBF is recruited to VRCs to promote viral DNA replication. ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2015.04.003

    authors： Ouellet Lavallée G,Pearson A

    更新日期：2015-09-01 00:00:00

  • Expression of authentic vaccinia virus-specific and inserted viral and cellular genes under control of an early vaccinia virus promoter is regulated post-transcriptionally in interferon-treated chick embryo fibroblasts.

    abstract：:The interferon sensitivity of the expression of an influenza-virus hemagglutinin (HA) gene cloned into the thymidine kinase (TK) gene of vaccinia virus was studied in chick embryo fibroblasts (CEF) and Madin-Darby bovine kidney (MDBK) cells. In CEF, the expression of the HA gene is inhibited by pretreatment of cells w...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(92)90740-g

    authors： Degen HJ,Blum D,Grün J,Jungwirth C

    更新日期：1992-05-01 00:00:00

  • Specificity of bipartite geminivirus movement proteins.

    abstract：:Pseudorecombinants produced by exchanging genome components (DNAs A and B) of the geminiviruses African cassava mosaic virus (ACMV) and Indian cassava mosaic virus (ICMV), ACMV, and tomato golden mosaic virus (TGMV), and TGMV and abutilon mosaic virus (AbMV) are not infectious in their common host Nicotiana benthamian...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1993.1523

    authors： Frischmuth T,Roberts S,von Arnim A,Stanley J

    更新日期：1993-10-01 00:00:00

  • A new and distinct species in the genus Caulimovirus exists as an endogenous plant pararetroviral sequence in its host, Dahlia variabilis.

    abstract：:Viruses in certain genera in family Caulimoviridae were shown to integrate their genomic sequences into their host genomes and exist as endogenous pararetroviral sequences (EPRV). However, members of the genus Caulimovirus remained to be the exception and are known to exist only as episomal elements in the infected ce...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2008.03.003

    authors： Pahalawatta V,Druffel K,Pappu H

    更新日期：2008-07-05 00:00:00