Abstract:
:Ovarian cancer is the third most common female cancer, with poor survival in later stages of metastatic spread. We test a chimeric virus consisting of genes from Lassa and vesicular stomatitis viruses, LASV-VSV; the native VSV glycoprotein is replaced by the Lassa glycoprotein, greatly reducing neurotropism. Human ovarian cancer cells in immunocompromised nude mice were lethal in controls. Chemotherapeutic paclitaxel and cisplatin showed modest cancer inhibition and survival extension. In contrast, a single intraperitoneal injection of LASV-VSV selectively infected and killed ovarian cancer cells, generating long-term survival. Mice with human ovarian cancer cells in brain showed rapid deterioration; LASV-VSV microinjection into brain blocked cancer growth, and generated long-term survival. Treatment of immunocompetent mice with infected mouse ovarian cancer cells blocked growth of non-infected ovarian cancer cells peritoneally and in brain. These results suggest LASV-VSV is a viable candidate for further study and may be of use in the treatment of ovarian cancer.
journal_name
Virologyjournal_title
Virologyauthors
van den Pol AN,Zhang X,Lima E,Pitruzzello M,Albayrak N,Alvero A,Davis JN,Mor Gdoi
10.1016/j.virol.2020.10.009subject
Has Abstractpub_date
2020-11-12 00:00:00pages
44-55eissn
0042-6822issn
1096-0341pii
S0042-6822(20)30211-7journal_volume
555pub_type
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