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The N-terminal portion of the 216-kDa polyprotein of Commelina yellow mottle badnavirus is required for virus movement but not for replication.

Abstract：

:Commelina yellow mottle virus (CoYMV) is the type member of the badnaviruses, a genus of plant pararetroviruses. The N-terminus of the polyprotein encoded by ORF III has limited similarity to known cell-to-cell movement proteins. To test the hypothesis that the N-terminus is required for viral movement, the phenotypes caused by mutations constructed in this region were determined. Similar to mutants affected in the reverse transcriptase, mutants affected in the putative movement protein were unable to cause a systemic infection. However, when the abilities of the mutated viral genomes to direct virion assembly and replication were tested using an in vitro stem-culture system, the mutants affected in the putative movement protein were found to assemble virions, whereas the reverse transcriptase mutants were unable to do so. Moreover, the putative movement protein mutants were shown to be replication competent by detection and mapping of one of the genomic discontinuities that are the hallmark of replication by reverse transcription. Thus the N-terminal region of ORF III is required for the systemic movement but not for the replication of CoYMV.

journal_name

Virology

journal_title

Virology

authors

Tzafrir I,Ayala-Navarrete L,Lockhart BE,Olszewski NE

doi

10.1006/viro.1997.8569

subject

Has Abstract

pub_date

1997-06-09 00:00:00

pages

359-68

issue

2

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(97)98569-X

journal_volume

232

pub_type

杂志文章

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