Abstract:
:We have examined the host range of AIDS-associated retroviruses (ARV) that are known to infect human T cells of the helper subset. We have observed that the virus cannot infect fibroblast and epithelial cell lines of many different animal species. It is infectious and replicates efficiently in peripheral mononuclear cells (PMC) of chimpanzee and at low levels in baboon and rhesus monkey PMC. Most importantly, it has been found to replicate in established lines of human B cells, monocytes, and promyelocytes. This ability to infect these other cell types appears to be associated, in most cases, with the presence of the Leu 3 T helper cell antigen on the cell surface. Other mechanisms for virus infection, however, may be involved. The results suggest that ARV will be found in other cells of AIDS patients, besides T cells, and that these cells could be the reservoir for continual virus spread in the host. Variations in the replicative ability of ARV isolates in human cells have also been noted; they could reflect potentially important pathogenic differences among these human retroviruses.
journal_name
Virologyjournal_title
Virologyauthors
Levy JA,Shimabukuro J,McHugh T,Casavant C,Stites D,Oshiro Ldoi
10.1016/0042-6822(85)90146-1subject
Has Abstractpub_date
1985-12-01 00:00:00pages
441-8issue
2eissn
0042-6822issn
1096-0341journal_volume
147pub_type
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