Abstract:
:Despite recent progress in the development of direct-acting antivirals against hepatitis C virus (HCV), chronic HCV infection remains an important health burden worldwide. MicroRNA122 (miR122), a liver-specific microRNA (miRNA), positively regulates HCV replication, and systemic application of antisense oligonucleotides against miR122 led to the long-lasting suppression of HCV viremia in human clinical trials. Here, we report that apigenin, a flavonoid and an inhibitor of maturation of a subset of miRNAs, inhibits HCV replication in vitro. Apigenin decreased the expression levels of mature miR122 without significantly affecting cell growth. Because supplementation of synthesized miR122 oligonucleotides or overexpression of constitutively active TRBP blocked these effects, the inhibitory effects of apigenin on HCV replication seemed to be dependent on the reduction of mature miR122 expression levels through inhibition of TRBP phosphorylation. Thus, apigenin intake, either through regular diet or supplements, may decrease HCV replication in chronically infected patients.
journal_name
Virologyjournal_title
Virologyauthors
Shibata C,Ohno M,Otsuka M,Kishikawa T,Goto K,Muroyama R,Kato N,Yoshikawa T,Takata A,Koike Kdoi
10.1016/j.virol.2014.05.024subject
Has Abstractpub_date
2014-08-01 00:00:00pages
42-8eissn
0042-6822issn
1096-0341pii
S0042-6822(14)00238-4journal_volume
462-463pub_type
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