The flavonoid apigenin inhibits hepatitis C virus replication by decreasing mature microRNA122 levels.

Abstract:

:Despite recent progress in the development of direct-acting antivirals against hepatitis C virus (HCV), chronic HCV infection remains an important health burden worldwide. MicroRNA122 (miR122), a liver-specific microRNA (miRNA), positively regulates HCV replication, and systemic application of antisense oligonucleotides against miR122 led to the long-lasting suppression of HCV viremia in human clinical trials. Here, we report that apigenin, a flavonoid and an inhibitor of maturation of a subset of miRNAs, inhibits HCV replication in vitro. Apigenin decreased the expression levels of mature miR122 without significantly affecting cell growth. Because supplementation of synthesized miR122 oligonucleotides or overexpression of constitutively active TRBP blocked these effects, the inhibitory effects of apigenin on HCV replication seemed to be dependent on the reduction of mature miR122 expression levels through inhibition of TRBP phosphorylation. Thus, apigenin intake, either through regular diet or supplements, may decrease HCV replication in chronically infected patients.

journal_name

Virology

journal_title

Virology

authors

Shibata C,Ohno M,Otsuka M,Kishikawa T,Goto K,Muroyama R,Kato N,Yoshikawa T,Takata A,Koike K

doi

10.1016/j.virol.2014.05.024

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

42-8

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(14)00238-4

journal_volume

462-463

pub_type

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