Abstract:
:Virus genomes are condensed and packaged inside stable proteinaceous capsids that serve to protect them during transit from one cell or host organism, to the next. During virus entry, capsid shells are primed and disassembled in a complex, tightly-regulated, multi-step process termed uncoating. Here we compare the uncoating-programs of DNA viruses of the pox-, herpes-, adeno-, polyoma-, and papillomavirus families. Highlighting the chemical and mechanical cues virus capsids respond to, we review the conformational changes that occur during stepwise disassembly of virus capsids and how these culminate in the release of viral genomes at the right time and cellular location to assure successful replication.
journal_name
Virologyjournal_title
Virologyauthors
Kilcher S,Mercer Jdoi
10.1016/j.virol.2015.01.024subject
Has Abstractpub_date
2015-05-01 00:00:00pages
578-90eissn
0042-6822issn
1096-0341pii
S0042-6822(15)00036-7journal_volume
479-480pub_type
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