Isolation of a Friend recombinant polytropic virus with a T-cell-restricted leukemogenicity.

Abstract:

:Hematopoietic malignant cells of various types were isolated from ICFW mice inoculated as newborn or adult with F-MuLV and grafted into recipient mice. After repeated in vivo cell transplants, several recombinant polytropic viruses (also termed MCF or dualtropic viruses) were isolated from tumors by limiting dilution. Two virus isolates designated RA1-17 and EA1-17 were recovered from the spleen and the omentum, respectively, of the same grafted animal. When inoculated into newborn mice, RA1-17 induced erythroblastosis similar to that induced by other Friend recombinant polytropic viruses. Remarkably, EA1-17 induced T-cell leukemia after a short latency. To our knowledge, this is the first description of a polytropic recombinant virus with a T-cell tropism isolated after inoculation of F-MuLV.

journal_name

Virology

journal_title

Virology

authors

Della-Valle V,Wendling F,Sitbon M,Varlet P,Mathieu-Mahul D,Larsen CJ

doi

10.1016/0042-6822(90)90360-4

subject

Has Abstract

pub_date

1990-10-01 00:00:00

pages

593-6

issue

2

eissn

0042-6822

issn

1096-0341

journal_volume

178

pub_type

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