The expressed VP4 protein of bluetongue virus binds GTP and is the candidate guanylyl transferase of the virus.

abstract：:Spherical virus particles were purified from larval striped jack (Pseudocaranx dentex) with nervous necrosis. The virus consists of nonenveloped particles, about 25 nm in diameter, and contains two single-stranded, positive-sense RNA molecules with molecular weights of 1.01 x 10(6)Da (RNA 1) and 0.49 x 10(6)Da (RNA 2)...

journal_title：Virology

authors： Mori K,Nakai T,Muroga K,Arimoto M,Mushiake K,Furusawa I

更新日期：1992-03-01 00:00:00

abstract：:We have previously adapted an experimental system which supports autonomous replication of human papillomavirus-11 (HPV-11) genomic DNA in a human squamous carcinoma cell line (SCC-4) following electroporation of linearized viral DNA. This system allows evaluation of HPV-11 transcription in the context of replicating ...

journal_title：Virology

authors： Renaud KJ,Cowsert LM

更新日期：1996-06-01 00:00:00

abstract：:The effect of rev (art/trs) gene on the level of HIV-1 envelope (env) expression using recombinant adenovirus was investigated. Recombinant adenoviruses expressing either the envelope or the rev gene of the human immunodeficiency virus type 1 (HIV-1) were constructed by inserting the gene into an expression cassette. ...

journal_title：Virology

authors： Chanda PK,Natuk RJ,Mason BB,Bhat BM,Greenberg L,Dheer SK,Molnar-Kimber KL,Mizutani S,Lubeck MD,Davis AR

更新日期：1990-04-01 00:00:00

abstract：:Cucumber mosaic virus (CMV) is a damaging pathogen of over 200 mono- and dicotyledonous crop species worldwide. It has the broadest known host range of any virus, but the timescale of its evolution is unknown. To investigate the evolutionary history of this virus, we obtained the genomic sequences of 40 CMV isolates f...

journal_title：Virology

authors： Ohshima K,Matsumoto K,Yasaka R,Nishiyama M,Soejima K,Korkmaz S,Ho SY,Gibbs AJ,Takeshita M

更新日期：2016-01-01 00:00:00

abstract：:GV1B is one of five viroids that have recently been purified from grapevines. GV1B has now been sequenced and its 363 nucleotide residues can potentially form the typical rod-like structure of viroids with 67% of nucleotides base-paired. GV1B has highest sequence similarity with grapevine yellow speckle viroid (GYSV; ...

journal_title：Virology

authors： Koltunow AM,Rezaian MA

更新日期：1989-06-01 00:00:00

abstract：:Aster yellows virus (AYV) was recovered from hemolymph, alimentary canal, salivary glands and ovaries, but not from Malpighian tubules, mycetomes, fat body, testes, or brain of viruliferous leafhoppers, Macrosteles fascifrons (Stål). The presence of virus in the tissues was determined by injecting their extracts into ...

journal_title：Virology

authors： Sinha RC,Chiykowski LN

更新日期：1967-12-01 00:00:00

abstract：:We determined the effect of the overproduction of viral nonstructural proteins on alphavirus plus-strand and minus-strand RNA synthesis. Because alphavirus minus-strand synthesis ceases normally at 3 to 4 hr postinfection and requires continuous protein synthesis [D. L. Sawicki and S. G. Sawicki, J. Virol. 34, 108-118...

journal_title：Virology

authors： Sawicki SG,Sawicki DL

更新日期：1986-07-30 00:00:00

abstract：:The ultrastructure of the mature and immature poxvirus Molluscum contagiosum has been examined by electron microscopy. With freeze-fracturing one fracture plane was observed in the viral envelope. During the conversion of immature into mature virus, particles inside the envelope become partly rearranged into parallel ...

journal_title：Virology

authors： Vreeswijk J,Kalsbeek GL,Nanninga N

更新日期：1977-11-01 00:00:00

abstract：:We have used field inversion gel electrophoresis to survey EBV strains for the size of the major internal repeat, IR-1, and estimate the number of 3.1-kb repeat units present. The B95-8 strain of EBV was estimated to contain 8.6 repeats. The repeat number varies considerably among naturally occurring isolates around a...

journal_title：Virology

authors： Allan GJ,Rowe DT

更新日期：1989-12-01 00:00:00

abstract：:The P150 and P90 replicase proteins of rubella virus (RUBV), a plus-strand RNA Togavirus, produce a unique cytoplasmic fiber network resembling microtubules. Pharmacological and mutagenic approaches were used to determine if these fibers functioned in virus replication. The pharmacological approach revealed that micro...

journal_title：Virology

authors： Matthews JD,Tzeng WP,Frey TK

更新日期：2010-10-25 00:00:00

abstract：:Experiments with monoclonal antibodies raised against two laboratory strains of Sindbis virus, SB and SIN, suggested the existence of a strain-specific neutralizing antigenic site (E2-b) on the E2 glycoprotein. A comparison of monoclonal antibody binding patterns and E2 glycoprotein gene sequences of six laboratory st...

journal_title：Virology

authors： Davis NL,Pence DF,Meyer WJ,Schmaljohn AL,Johnston RE

更新日期：1987-11-01 00:00:00

abstract：:The spread of HIV-1 to the nervous system occurs early during infection in a large number of asymptomatic virus carriers. In order to address the question whether the brain is targeted by a group of HIV-1 variants with increased neurotropic properties we have obtained 20 paired isolates from the blood and cerebrospina...

journal_title：Virology

authors： Keys B,Karis J,Fadeel B,Valentin A,Norkrans G,Hagberg L,Chiodi F

更新日期：1993-10-01 00:00:00

abstract：:The expression of cytokines may influence the development of lymphoma in retrovirally infected animals in at least two ways: (1) cytokines in the tumor environment may stimulate the proliferation of tumor cells and/or (2) cytokines in the tumor environment may diminish the cell-mediated antitumor immune response. To e...

journal_title：Virology

authors： Beaty RM,Rulli K,Bost KL,Pantginis J,Lenz J,Levy LS

更新日期：1999-09-01 00:00:00

abstract：:The Rice stripe virus (RSV) pc4 has been determined as the viral movement protein (MP). In this study, the pc4 gene was cloned into a movement-deficient Tobacco mosaic virus (TMV). The resulting hybrid TMV-pc4, in addition to spreading cell to cell in Nicotiana tabacum, moved systemically and induced foliar necrosis i...

journal_title：Virology

authors： Zhang C,Pei X,Wang Z,Jia S,Guo S,Zhang Y,Li W

更新日期：2012-04-10 00:00:00

abstract：:Replication of Tomato bushy stunt virus (TBSV) RNA takes place on the cytosolic membrane surface of peroxisomes in plants and in yeast, a model host. To identify the host proteins involved in assisting the peroxisomal localization of the tombusvirus p33 replication protein, we tested if p33 could bind directly to yeas...

journal_title：Virology

authors： Pathak KB,Sasvari Z,Nagy PD

更新日期：2008-09-30 00:00:00

abstract：:3H-labelled complementary DNA (cDNA) was reverse transcribed from the RNA of three biologically distinct isolates of bean yellow mosaic virus (BYMV-G, Q, and S) by the random primer method of Taylor et al. [Biochim. Biophys. Acta 442, 324-330 (1976)]. Excess virus RNA was hybridized with each of the cDNAs and percenta...

journal_title：Virology

authors： Abu-Samah N,Randles JW

更新日期：1981-04-30 00:00:00

abstract：:Human infection with H7N9 virus has provoked global public health concern due to the substantial morbidity and mortality. Neuraminidase inhibitors (NAIs) are used as first-line drugs to treat the infection. However, virus quasispecies can evolve rapidly under drug pressure, which may alter various biological character...

journal_title：Virology

authors： Ge Y,Chi Y,Min X,Zhao K,Wu B,Wu T,Zhu X,Shi Z,Zhu F,Cui L

更新日期：2019-10-01 00:00:00

abstract：:Human hepatitis B virus (HBV) envelopes contain three distinct glycoproteins called L, M, and S HBsAg. Each is posttranslationally modified to contain N-linked oligosaccharides. N-linked oligosaccharides, after attachment to a polypeptide backbone, are processed by enzymes within the endoplasmic reticulum (ER). There ...

journal_title：Virology

authors： Lu X,Mehta A,Dwek R,Butters T,Block T

更新日期：1995-11-10 00:00:00

abstract：:Proviral sequences encoding defective HIV-1 regulatory genes have been detected previously in infected individuals; however, the role of these defective genomes in pathogenesis is unclear. The hypothesis that such replication-defective genomes might induce downregulation of the cellular receptor for HIV-1 (CD4) was te...

journal_title：Virology

authors： Little SJ,Riggs NL,Chowers MY,Fitch NJ,Richman DD,Spina CA,Guatelli JC

更新日期：1994-12-01 00:00:00

abstract：:The binding of monoclonal antibodies to antigenic site 3 on the hemagglutinin-neuraminidase (HN) glycoprotein of Newcastle disease virus neutralizes viral infectivity and prevents syncytium formation by a mechanism other than the prevention of viral attachment. The virus can escape neutralization by these antibodies b...

journal_title：Virology

authors： Deng R,Wang Z,Glickman RL,Iorio RM

更新日期：1994-10-01 00:00:00

abstract：:Foot-and-mouth disease virus (FMDV) shows a remarkable antigenic variability. Like other RNA viruses, this virus has a high rate of mutation. It has been proposed that selection exerted by the host's antibodies could play a major role in the rapid evolution of FMDV. The present work reports the selection of FMDV antib...

journal_title：Virology

authors： Carrillo EC,Rojas ER,Cavallaro L,Schiappacassi M,Campos R

更新日期：1989-08-01 00:00:00

abstract：:Efforts to generate a vaccine to prevent infection by human immunodeficiency virus (HIV) have focused on inducing neutralizing antibodies. However, cytotoxic T-lymphocyte (CTL) responses are a major immune defense mechanism required for recovery from many different virus infections. Since CTL epitopes can be defined b...

journal_title：Virology

authors： Sastry KJ,Nehete PN,Venkatnarayanan S,Morkowski J,Platsoucas CD,Arlinghaus RB

更新日期：1992-06-01 00:00:00

abstract：:The molecular analysis of three ovine pestivirus strains revealed the existence of two distinct groups of sheep-derived pestiviruses, namely "true" border disease virus strains (BDV) and bovine viral diarrhea virus (BVDV)-like strains. As an extension of these studies RT-PCR and nucleotide sequencing of the autoprotea...

journal_title：Virology

authors： Becher P,König M,Paton DJ,Thiel HJ

更新日期：1995-05-10 00:00:00

abstract：:La Crosse (LAC) virions exposed to different pHs (7.3, 6.2, and 5.4) and temperatures (37 degrees, 20 degrees, and 4 degrees) were preserved in thin layers of vitreous ice and observed by electron cryomicroscopy. Our results indicate that, at lower pH, virus particles interact with each other to form aggregates. In so...

journal_title：Virology

authors： Wang GJ,Hewlett M,Chiu W

更新日期：1991-09-01 00:00:00

abstract：:Previously our laboratory constructed an HIV-1 which stably maintained a primer binding site (PBS) complementary to tRNA(His) by mutating the region of the provirus within U5 postulated to interact with the anticodon of tRNA(His) (J. Wakefield, S-M Kang, and C. D. Morrow, 1996, J. Virol, 70, 966-975). From the analysi...

journal_title：Virology

authors： Li Y,Zhang Z,Kang SM,Buescher JL,Morrow CD

更新日期：1997-11-24 00:00:00

abstract：:Plasmids containing the E1 region of Ad12 DNA can transform certain rodent cells into oncogenic cells. To study the role of the E1a subregion in the process of oncogenic transformation, Ad12 region E1 mutants carrying deletions in the E1a region were constructed. Deletion mutants pR7 and pR8 affect only the 13 S mRNA ...

journal_title：Virology

authors： Bos JL,Jochemsen AG,Bernards R,Schrier PI,van Ormondt H,van der Eb AJ

更新日期：1983-09-01 00:00:00

abstract：:This work investigated whether the Escherichia coli RNase III gene, rnc+, could complement vp1080, a mutant vaccinia virus that is deleted of its E3L gene. Like E3L, rnc+ codes for a dsRNA binding protein that contains an additional nucleolytic activity. Rnc genes were cloned into the eukaryotic expression vector pMTV...

journal_title：Virology

authors： Shors T,Jacobs BL

更新日期：1997-01-06 00:00:00

abstract：:Arabis mosaic virus is a subgroup A nepovirus. The RNA1-encoded polyprotein (P1) contains the domains for the NTP-binding protein (NTB), VPg, proteinase (Pro) and polymerase at its C-terminus. Putative cleavage sites delineating these domains have been proposed. However, the number and location of cleavage sites upstr...

journal_title：Virology

authors： Wetzel T,Chisholm J,Bassler A,Sanfaçon H

更新日期：2008-05-25 00:00:00

abstract：:Viral functions essential for the establishment of latent infection in murine sensory neurons in vivo were investigated by employing a herpes simplex virus type 1 (HSV-1) variant (KD6/B11) deleted for expression of the ICP4 gene and therefore unable to replicate. Since the viral DNA persisted in these cells, the laten...

journal_title：Virology

authors： Sedarati F,Margolis TP,Stevens JG

更新日期：1993-02-01 00:00:00

abstract：:Although dengue (DEN) virus is the etiologic agent of dengue fever, the most prevalent vector-borne viral disease in the world, precise information on the antigenic structure of the dengue virion is limited. We have prepared a set of murine monoclonal antibodies (MAbs) specific for the envelope (E) glycoprotein of DEN...

journal_title：Virology

authors： Roehrig JT,Bolin RA,Kelly RG

更新日期：1998-07-05 00:00:00