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Influenza virus polymerase confers independence of the cellular cap-binding factor eIF4E for viral mRNA translation.

Abstract：

:The influenza virus mRNAs are structurally similar to cellular mRNAs nevertheless; the virus promotes selective translation of viral mRNAs despite the inhibition of host cell protein synthesis. The infection proceeds normally upon functional impairment of eIF4E cap-binding protein, but requires functional eIF4A helicase and eIF4G factor. Here, we have studied whether the presence of cis elements in viral mRNAs or the action of viral proteins is responsible for this eIF4E-independence. The eIF4E protein is required for viral mRNA translation in vitro, indicating that cis-acting RNA sequences are not involved in this process. We also show that PB2 viral polymerase subunit interacts with the eIF4G protein. In addition, a chimeric mRNA containing viral UTR sequences transcribed by the viral polymerase out of the infection is successfully translated independently of an impaired eIF4E factor. These data support that the viral polymerase is responsible for the eIF4E independence of influenza virus mRNA translation.

journal_name

Virology

journal_title

Virology

authors

Yángüez E,Rodriguez P,Goodfellow I,Nieto A

doi

10.1016/j.virol.2011.10.028

subject

Has Abstract

pub_date

2012-01-20 00:00:00

pages

297-307

issue

2

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(11)00515-0

journal_volume

422

pub_type

杂志文章

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