abstract：:MS is a multifactorial disease in which a series of genetic and non-genetic, environmental factors plays a role in its etiology. In particular, HLA class II alleles, mainly HLADRB1*15:01 (HLA-DR15), increase the risk for this disease. Out of several environmental factors, and with regard to infections, EBV remains to ...

journal_title：European journal of immunology

authors： Olsson T

更新日期：2020-12-22 00:00:00

abstract：:Low concentrations of type-I interferon (IFN) in blood seem to be associated with more severe forms of Coronavirus disease 2019 (COVID-19). However, following the type-I interferon response (IR) in early stage disease is a major challenge. We evaluated detection of a molecular interferon signature on a FilmArray® syst...

journal_title：European journal of immunology

authors： Mommert M,Perret M,Hockin M,Viel S,Belot A,Richard JC,Mezidi M,Fassier JB,Javouhey E,ANTOINE Study Group.,COVID-SER Study Group.,COVID-HCL Study Group.,Hemmert A,Mallet F,Trouillet-Assant S,Brengel-Pesce K

更新日期：2020-12-12 00:00:00

abstract：:Human ILCs are classically categorized into five subsets; cytotoxic CD127- CD94+ NK cells and non-cytotoxic CD127+ CD94- , ILC1s, ILC2s, ILC3s, and LTi cells. Here, we identify a previously unrecognized subset within the CD127+ ILC population, characterized by the expression of the cytotoxic marker CD94. These CD94+ I...

journal_title：European journal of immunology

authors： Krabbendam L,Heesters BA,Kradolfer CMA,Spits H,Bernink JH

更新日期：2020-12-09 00:00:00

abstract：:Chronic macrophage inflammation is a hallmark of type 2 diabetes (T2D) and linked to the development of secondary diabetic complications. T2D is characterized by excess concentrations of saturated fatty acids (SFA) that activate innate immune inflammatory responses, however, mechanism(s) by which SFAs control inflamma...

journal_title：European journal of immunology

authors： Davis FM,denDekker A,Joshi AD,Wolf SJ,Audu C,Melvin WJ,Mangum K,Riordan MO,Kunkel SL,Gallagher KA

更新日期：2020-12-01 00:00:00

abstract：:IL-10, produced by a wide variety of cells, is a highly pleiotropic cytokine that plays a critical role in the control of immune responses. However, its regulatory activity in tumor immunity remains poorly understood. In this study, we report that IL-10 deficiency robustly suppressed the formation of malignant pleural...

journal_title：European journal of immunology

authors： Zhai K,Shi XY,Yi FS,Huang ZY,Wu XZ,Dong SF,Wang W,Wu MT,Shi HZ

更新日期：2020-11-01 00:00:00

abstract：:Diacylglycerol kinases (DGKs) play important roles in restraining diacylglycerol (DAG)-mediated signaling. Within the DGK family, the ζ isoform appears to be the most important isoform in T cells for controlling their development and function. DGKζ has been demonstrated to regulate T cell maturation, activation, anerg...

journal_title：European journal of immunology

authors： Xie D,Zhang S,Chen P,Deng W,Pan Y,Xie J,Wang J,Liao B,Sleasman JW,Zhong XP

更新日期：2020-11-01 00:00:00

abstract：:Pulmonary mucosal immune response is critical for preventing opportunistic Aspergillus fumigatus infections. Although fungus-specific CD4+ T cells in blood are described to reflect the actual host-pathogen interaction status, little is known about Aspergillus-specific pulmonary T-cell responses. Here, we exploit the d...

journal_title：European journal of immunology

authors： Schmidt S,Ebner F,Rosen K,Kniemeyer O,Brakhage AA,Löffler J,Seif M,Springer J,Schlosser J,Scharek-Tedin L,Scheffold A,Bacher P,Kühl AA,Rösler U,Hartmann S

更新日期：2020-11-01 00:00:00

abstract：:Using a specific antibody, we found that expression of the viral restriction factor IFITM3 differs across cell types within the immune compartment with higher expression in myeloid rather than lymphoid cells. IFITM3 expression was increased following IFN stimulation, mostly type I, in immune cells, with the exception ...

journal_title：European journal of immunology

authors： Wellington D,Yin Z,Abdel-Haq A,Zhang L,Forbester J,Kite K,Rajapaksa U,Laurenson-Schafer H,Makvandi-Nejad S,Jin B,Bowes E,Manoharan K,Maldonado-Perez D,Verrill C,Humphreys IR,Dong T

更新日期：2020-10-30 00:00:00

abstract：:Infection with parasitic worms (helminths) alters host immune responses and can inhibit pathogenic inflammation. Helminth infection promotes a strong Th2 and T regulatory response while suppressing Th1 and Th17 function. Th2 responses are largely dependent on transcriptional programs directed by Stat6-signaling. We ex...

journal_title：European journal of immunology

authors： Metwali A,Winckler S,Urban JF Jr,Kaplan MH,Ince MN,Elliott DE

更新日期：2020-10-16 00:00:00

abstract：:This evidence-based clinical guideline provides consensus-recommendations for the treatment and care of patients with primary antibody deficiencies (PADs). The guideline group comprised 20 clinical and scientific expert associations of the German, Swiss, and Austrian healthcare system and representatives of patients. ...

journal_title：European journal of immunology

authors： Hanitsch L,Baumann U,Boztug K,Burkhard-Meier U,Fasshauer M,Habermehl P,Hauck F,Klock G,Liese J,Meyer O,Müller R,Pachlopnik-Schmid J,Pfeiffer-Kascha D,Warnatz K,Wehr C,Wittke K,Niehues T,von Bernuth H

更新日期：2020-10-01 00:00:00

abstract：:Cellular metabolism is dynamically regulated in NK cells and strongly influences their responses. Metabolic dysfunction is linked to defective NK cell responses in diseases such as obesity and cancer. The transcription factors, sterol regulatory element binding protein (SREBP) and cMyc, are crucial for controlling NK ...

journal_title：European journal of immunology

authors： O'Brien KL,Assmann N,O'Connor E,Keane C,Walls J,Choi C,Oefner PJ,Gardiner CM,Dettmer K,Finlay DK

更新日期：2020-09-18 00:00:00

abstract：:Inflammatory bowel diseases (IBD) are chronic conditions that result from uncontrolled intestinal inflammation. Pathogenic Th17 cells, characterized by production of IL-17A in the absence of IL-10, are thought to contribute to this inflammation, but in humans, antibody-mediated blockade of IL-17A is an ineffective IBD...

journal_title：European journal of immunology

authors： Boardman DA,Garcia RV,Ivison SM,Bressler B,Dhar TM,Zhao Q,Levings MK

更新日期：2020-09-01 00:00:00

abstract：:Profiling antibodies to SARS-CoV-2 can help to assess potential immune response after COVID-19 disease. Luciferase IP system (LIPS) assay is a sensitive method for quantitative detection of antibodies to antigens in their native conformation. We here describe LIPS to detect antibody responses to SARS-CoV-2 spike (S) a...

journal_title：European journal of immunology

authors： Haljasmägi L,Remm A,Rumm AP,Krassohhina E,Sein H,Tamm A,Kisand K,Peterson P

更新日期：2020-08-01 00:00:00

abstract：:The IFN stimulated gene 15 (ISG15) encodes a 15-kDa ubiquitin-like protein, that is induced by type I IFNs and is conjugated to the bulk of newly synthesized polypeptides at the ribosome. ISG15 functions as an antiviral molecule possibly by being covalently conjugated to viral proteins and disturbing virus particle as...

journal_title：European journal of immunology

authors： Held T,Basler M,Knobeloch KP,Groettrup M

更新日期：2020-07-20 00:00:00

abstract：:Interleukin-31 (IL-31) is a Th2 cell-derived cytokine that has been closely linked to pruritic skin inflammation. More recently, enhanced IL-31 serum levels have also been observed in patients with allergic rhinitis and allergic asthma. Therefore, the main aim of this study was to unravel the contribution of IL-31 to ...

journal_title：European journal of immunology

authors： Neuper T,Neureiter D,Sarajlic M,Strandt H,Bauer R,Schwarz H,Suchanek P,Korotchenko E,Dillon SR,Hammerl P,Stoecklinger A,Weiss R,Horejs-Hoeck J

更新日期：2020-07-10 00:00:00

abstract：:Several drugs targeting members of the TNF superfamily or TNF receptor superfamily (TNFRSF) are widely used in medicine or are currently being tested in therapeutic trials. However, their mechanism of action remains poorly understood. Here, we explored the effects of TNFRSF co-stimulation on murine Foxp3+ regulatory T...

journal_title：European journal of immunology

authors： Lubrano di Ricco M,Ronin E,Collares D,Divoux J,Grégoire S,Wajant H,Gomes T,Grinberg-Bleyer Y,Baud V,Marodon G,Salomon BL

更新日期：2020-07-01 00:00:00

abstract：:AMPK (adenosine monophosphate-activated protein kinase) is phosphorylated (AMPK-P) in response to low energy through allosteric activation by Adenosine mono- or diphosphate (AMP/ADP). Folliculin (FLCN) and the FLCN-interacting proteins 1 and 2 (FNIP1, 2) modulate AMPK. FNIP1 deficiency patients have a AMPK-P gain of f...

journal_title：European journal of immunology

authors： Niehues T,Özgür TT,Bickes M,Waldmann R,Schöning J,Bräsen J,Hagel C,Ballmaier M,Klusmann JH,Niedermayer A,Pannicke U,Enders A,Dückers G,Siepermann K,Hempel J,Schwarz K,Viemann D

更新日期：2020-07-01 00:00:00

abstract：:The transcription factor Hhex (hematopoietically expressed homeobox gene) is critical for development of multiple lymphoid lineages beyond the common lymphoid progenitor. In addition, Hhex regulates hematopoietic stem cell (HSC) self-renewal, emergency hematopoiesis, and acute myeloid leukemia initiation and maintenan...

journal_title：European journal of immunology

authors： Jackson JT,O'Donnell K,Light A,Goh W,Huntington ND,Tarlinton DM,McCormack MP

更新日期：2020-07-01 00:00:00

abstract：:In the past 15 years, it became clear that the symbiotic microbiota has an important impact on the development and regulation of the immune system. Consequently, it is incorrect to interpret a phenotype solely as a direct result of the genotype, without considering the impact of the microbiota. In fact, ignorance of t...

journal_title：European journal of immunology

authors： Eberl G,Vieira P

更新日期：2020-06-01 00:00:00

abstract：:The immune system is tightly regulated by a subset of T cells defined as regulatory T cells (Tregs). Tregs maintain immune homeostasis by restraining unwarranted immune cell activation and effector function. Here, we discuss an important but underappreciated role of proteases in controlling Treg function. Proteases re...

journal_title：European journal of immunology

authors： Amarnath S,Brown ML

更新日期：2020-06-01 00:00:00

abstract：:In humans and mice, mucosal immune responses are dominated by IgA antibodies and the cytokine TGF-β, suppressing unwanted immune reactions but also targeting Ig class switching to IgA. It had been suggested that eosinophils promote the generation and maintenance of mucosal IgA-expressing plasma cells. Here, we demonst...

journal_title：European journal of immunology

authors： Beller A,Kruglov A,Durek P,von Goetze V,Werner K,Heinz GA,Ninnemann J,Lehmann K,Maier R,Hoffmann U,Riedel R,Heiking K,Zimmermann J,Siegmund B,Mashreghi MF,Radbruch A,Chang HD

更新日期：2020-06-01 00:00:00

abstract：:Terminal differentiation of B cells into antibody-secreting cells is the foundation of humoral immune response. B-1 cells, which are different from B-2 cells, preferentially differentiate into plasma cells. CMTM7 is a MARVEL-domain-containing membrane protein predominantly expressed in B cells that plays an important ...

journal_title：European journal of immunology

authors： Liu Z,Liu Y,Li T,Wang P,Mo X,Lv P,Ma D,Han W

更新日期：2020-06-01 00:00:00

abstract：:Maintenance of homeostasis at body barriers that are constantly challenged by microbes, toxins and potentially bioactive (macro)molecules requires complex, highly orchestrated mechanisms of protection. Recent discoveries in respiratory research have shed light on the unprecedented role of airway epithelial cells (AEC)...

journal_title：European journal of immunology

authors： Smole U,Kratzer B,Pickl WF

更新日期：2020-05-01 00:00:00

abstract：:CD5 is expressed on T cells and a subset of B cells (B1a). It can attenuate TCR signalling and impair CTL activation and is a therapeutic targetable tumour antigen expressed on leukemic T and B cells. However, the potential therapeutic effect of functionally blocking CD5 to increase T cell anti-tumour activity against...

journal_title：European journal of immunology

authors： Alotaibi F,Rytelewski M,Figueredo R,Zareardalan R,Zhang M,Ferguson PJ,Maleki Vareki S,Najajreh Y,El-Hajjar M,Zheng X,Min WP,Koropatnick J

更新日期：2020-05-01 00:00:00

abstract：:It is well established that therapeutic impairment of Foxp3+ Treg in mice and humans favors immune rejection of solid tumors. Less explored is the impact Foxp3 allelic variants may have on tumor incidence, progression and therapy. In this work, we tested and demonstrate that the Foxp3fgfp reporter allele, found previo...

journal_title：European journal of immunology

authors： Almeida-Santos J,Bergman ML,Amendoeira Cabral I,Correia V,Caramalho Í,Demengeot J

更新日期：2020-03-01 00:00:00

abstract：:The NLRP3 inflammasome is a molecular complex that translates signals from pathogens and tissue damage into inflammatory responses, and plays crucial roles in numerous neurological diseases. Activation of the NLRP3 inflammasome leads to caspase-1 dependent cleavage of pro-IL-1β to form mature IL-1β. By acting on the P...

journal_title：European journal of immunology

authors： Suzuki T,Kohyama K,Moriyama K,Ozaki M,Hasegawa S,Ueno T,Saitoe M,Morio T,Hayashi M,Sakuma H

更新日期：2020-02-01 00:00:00

abstract：:Recent years have seen a dramatic increase in the range of applications of virus-like nanoparticle (VNP)- and liposome-based antigen delivery systems for the treatment of allergies. These platforms rely on a growing number of inert virus-backbones or distinct lipid formulations and intend to engage the host's innate a...

journal_title：European journal of immunology

authors： Kratzer B,Hofer S,Zabel M,Pickl WF

更新日期：2020-01-01 00:00:00

abstract：:The semi-public T-cell response towards the gluten epitope DQ2.5-glia-α2 uses a prototypic TCR encoded by the germline segments TRAV26-1 and TRBV7-2. Through mutagenesis experiments, we show that a TRAV26-1encoded recognition motif contacts the MHC β-chain and the TCR CDR3β loop underpinning this conserved T-cell resp...

journal_title：European journal of immunology

authors： Frick R,Gunnarsen KS,Dahal-Koirala S,Risnes LF,Sollid LM,Sandlie I,Høydahl LS,Løset GÅ

更新日期：2020-01-01 00:00:00

abstract：:The role of redox regulation in immune-mediated arthritis has been previously described. However, the relationship between innate immune cells, including innate lymphoid cells (ILCs) and phagocyte-derived ROS, in this process remains unclear. Here, we characterize ILCs and measure the IL-1 family cytokines along with ...

journal_title：European journal of immunology

authors： Chan TY,Yen CL,Huang YF,Lo PC,Nigrovic PA,Cheng CY,Wang WZ,Wu SY,Shieh CC

更新日期：2019-11-01 00:00:00

abstract：:Changes in the epigenetic landscape of immune cells are a crucial component of gene activation during the induction of inflammatory responses, therefore it has been hypothesized that epigenetic modulation could be employed to restore homeostasis in inflammatory scenarios. Fungal pathogens cause a large burden of morbi...

journal_title：European journal of immunology

authors： Domínguez-Andrés J,Ferreira AV,Jansen T,Smithers N,Prinjha RK,Furze RC,Netea MG

更新日期：2019-11-01 00:00:00

abstract：:Nonhematopoietic stromal cells contribute to the organization and homeostasis of secondary lymphoid organs by producing cytokines and chemokines. The development and maintenance of these stromal cells are thought to be regulated by innate immune cells. Indeed, we recently showed that signal regulatory protein α (SIRPα...

journal_title：European journal of immunology

authors： Komori S,Saito Y,Respatika D,Nishimura T,Kotani T,Murata Y,Matozaki T

更新日期：2019-09-01 00:00:00

abstract：:Bone marrow (BM) stromal cells are important in the development and maintenance of cells of the immune system. Using single cell RNA sequencing, we here explore the functional and phenotypic heterogeneity of individual transcriptomes of 1167 murine BM mesenchymal stromal cells. These cells exhibit a tremendous heterog...

journal_title：European journal of immunology

authors： Addo RK,Heinrich F,Heinz GA,Schulz D,Sercan-Alp Ö,Lehmann K,Tran CL,Bardua M,Matz M,Löhning M,Hauser AE,Kruglov A,Chang HD,Durek P,Radbruch A,Mashreghi MF

更新日期：2019-09-01 00:00:00

abstract：:Activated allergen-specific Th2 and Th1 cells release cytokines that transform neutrophils into functional APCs characterized by the expression of HLA-DR and CD58 as well as enhanced survival and antigen uptake, irrespectively of the presence of IL-10, which reduces allergen uptake by neutrophils. ...

journal_title：European journal of immunology

authors： Samadi N,Polak D,Kitzmüller C,Steinberger P,Zlabinger GJ,Jahn-Schmid B,Bohle B

更新日期：2019-09-01 00:00:00

abstract：:The successful implementation of immunotherapies has provided new impetus in the fight against cancer. Antibody-mediated blockade of immune checkpoint molecules PD-1/PD-L1 and CTLA-4 has had a dramatic impact upon the treatment of previously intractable cancers such as malignant melanoma, while adoptive cell therapies...

journal_title：European journal of immunology

authors： Hope HC,Salmond RJ

更新日期：2019-08-01 00:00:00

abstract：:Cytokine-induced memory-like (CIML) NK cells are endowed with the capacity to mediate enhanced effector functions upon cytokine or activating receptor restimulation for several weeks following short-term preactivation with IL-12, IL-15, and IL-18. Promising results from a first-in-human clinical trial highlighted the ...

journal_title：European journal of immunology

authors： Ghofrani J,Lucar O,Dugan H,Reeves RK,Jost S

更新日期：2019-08-01 00:00:00

abstract：:Human herpes virus 6B (HHV-6B) is a widespread virus that infects most people early in infancy and establishes a chronic life-long infection with periodic reactivation. CD4 T cells have been implicated in control of HHV-6B, but antigenic targets and functional characteristics of the CD4 T-cell response are poorly unde...

journal_title：European journal of immunology

authors： Becerra-Artiles A,Cruz J,Leszyk JD,Sidney J,Sette A,Shaffer SA,Stern LJ

更新日期：2019-08-01 00:00:00

abstract：:NLRP3 inflammasome is a protein complex crucial to caspase-1 activation and IL-1β and IL-18 maturation. This receptor participates in innate immune responses to different pathogens, including the bacteria of genus Brucella. Our group recently demonstrated that Brucella abortus-induced IL-1β secretion involves NLRP3 in...

journal_title：European journal of immunology

authors： Campos PC,Gomes MTR,Marinho FAV,Guimarães ES,de Moura Lodi Cruz MGF,Oliveira SC

更新日期：2019-07-01 00:00:00

abstract：:The immune and endocrine systems ensure two vital functions in the body. The immune system protects us from lethal pathogens, whereas the endocrine system ensures proper metabolic function of peripheral organs by regulating systemic homeostasis. These two systems were long thought to operate independently. The immune ...

journal_title：European journal of immunology

authors： Wensveen FM,Šestan M,Turk Wensveen T,Polić B

更新日期：2019-07-01 00:00:00

abstract：:The BCR plays a central role in B cell development, survival, activation, and differentiation. We have identified the B cell novel protein 1 (BCNP1) as a new regulator of BCR signaling. BCNP1 contains a pleckstrin homology domain, three proline-rich motifs, and a potential SH2 binding site, and is predominantly expres...

journal_title：European journal of immunology

authors： Hong R,Lai N,Ouchida R,Xiong E,Zhou Y,Min Q,Liu J,Tang Y,Hikida M,Tsubata T,Wang Y,Wang JY

更新日期：2019-06-01 00:00:00

abstract：:Antioxidant systems maintain cellular redox homeostasis. The thioredoxin-1 (Trx1) and the glutathione (GSH)/glutaredoxin-1 (Grx1) systems are key players in preserving cytosolic redox balance. In fact, T lymphocytes critically rely on reducing equivalents from the Trx1 system for DNA biosynthesis during metabolic repr...

journal_title：European journal of immunology

authors： Muri J,Thut H,Heer S,Krueger CC,Bornkamm GW,Bachmann MF,Kopf M

更新日期：2019-05-01 00:00:00