听力与言语-语言病理学

行为科学

医学伦理学

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  • Epstein Barr virus infection and immune defense related to HLA-DR15: consequences for multiple sclerosis.

    abstract::MS is a multifactorial disease in which a series of genetic and non-genetic, environmental factors plays a role in its etiology. In particular, HLA class II alleles, mainly HLADRB1*15:01 (HLA-DR15), increase the risk for this disease. Out of several environmental factors, and with regard to infections, EBV remains to ...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.202049030

    authors: Olsson T

    更新日期:2020-12-22 00:00:00

  • Type-I Interferon assessment in 45 minutes using the FilmArray® PCR platform in SARS-CoV-2 and other viral infections.

    abstract::Low concentrations of type-I interferon (IFN) in blood seem to be associated with more severe forms of Coronavirus disease 2019 (COVID-19). However, following the type-I interferon response (IR) in early stage disease is a major challenge. We evaluated detection of a molecular interferon signature on a FilmArray® syst...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.202048978

    authors: Mommert M,Perret M,Hockin M,Viel S,Belot A,Richard JC,Mezidi M,Fassier JB,Javouhey E,ANTOINE Study Group.,COVID-SER Study Group.,COVID-HCL Study Group.,Hemmert A,Mallet F,Trouillet-Assant S,Brengel-Pesce K

    更新日期:2020-12-12 00:00:00

  • Identification of human cytotoxic ILC3s.

    abstract::Human ILCs are classically categorized into five subsets; cytotoxic CD127- CD94+ NK cells and non-cytotoxic CD127+ CD94- , ILC1s, ILC2s, ILC3s, and LTi cells. Here, we identify a previously unrecognized subset within the CD127+ ILC population, characterized by the expression of the cytotoxic marker CD94. These CD94+ I...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.202048696

    authors: Krabbendam L,Heesters BA,Kradolfer CMA,Spits H,Bernink JH

    更新日期:2020-12-09 00:00:00

  • Palmitate-TLR4 signaling regulates the histone demethylase, JMJD3, in macrophages and impairs diabetic wound healing.

    abstract::Chronic macrophage inflammation is a hallmark of type 2 diabetes (T2D) and linked to the development of secondary diabetic complications. T2D is characterized by excess concentrations of saturated fatty acids (SFA) that activate innate immune inflammatory responses, however, mechanism(s) by which SFAs control inflamma...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.202048651

    authors: Davis FM,denDekker A,Joshi AD,Wolf SJ,Audu C,Melvin WJ,Mangum K,Riordan MO,Kunkel SL,Gallagher KA

    更新日期:2020-12-01 00:00:00

  • IL-10 promotes malignant pleural effusion by regulating TH 1 response via an miR-7116-5p/GPR55/ERK pathway in mice.

    abstract::IL-10, produced by a wide variety of cells, is a highly pleiotropic cytokine that plays a critical role in the control of immune responses. However, its regulatory activity in tumor immunity remains poorly understood. In this study, we report that IL-10 deficiency robustly suppressed the formation of malignant pleural...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.202048574

    authors: Zhai K,Shi XY,Yi FS,Huang ZY,Wu XZ,Dong SF,Wang W,Wu MT,Shi HZ

    更新日期:2020-11-01 00:00:00

  • Negative control of diacylglycerol kinase ζ-mediated inhibition of T cell receptor signaling by nuclear sequestration in mice.

    abstract::Diacylglycerol kinases (DGKs) play important roles in restraining diacylglycerol (DAG)-mediated signaling. Within the DGK family, the ζ isoform appears to be the most important isoform in T cells for controlling their development and function. DGKζ has been demonstrated to regulate T cell maturation, activation, anerg...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.201948442

    authors: Xie D,Zhang S,Chen P,Deng W,Pan Y,Xie J,Wang J,Liao B,Sleasman JW,Zhong XP

    更新日期:2020-11-01 00:00:00

  • The domestic pig as human-relevant large animal model to study adaptive antifungal immune responses against airborne Aspergillus fumigatus.

    abstract::Pulmonary mucosal immune response is critical for preventing opportunistic Aspergillus fumigatus infections. Although fungus-specific CD4+ T cells in blood are described to reflect the actual host-pathogen interaction status, little is known about Aspergillus-specific pulmonary T-cell responses. Here, we exploit the d...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.201948524

    authors: Schmidt S,Ebner F,Rosen K,Kniemeyer O,Brakhage AA,Löffler J,Seif M,Springer J,Schlosser J,Scharek-Tedin L,Scheffold A,Bacher P,Kühl AA,Rösler U,Hartmann S

    更新日期:2020-11-01 00:00:00

  • IFITM3-specific antibody reveals IFN preferences and slow IFN induction of the antiviral factor IFITM3 in humans.

    abstract::Using a specific antibody, we found that expression of the viral restriction factor IFITM3 differs across cell types within the immune compartment with higher expression in myeloid rather than lymphoid cells. IFITM3 expression was increased following IFN stimulation, mostly type I, in immune cells, with the exception ...

    journal_title:European journal of immunology

    pub_type: 信件

    doi:10.1002/eji.202048706

    authors: Wellington D,Yin Z,Abdel-Haq A,Zhang L,Forbester J,Kite K,Rajapaksa U,Laurenson-Schafer H,Makvandi-Nejad S,Jin B,Bowes E,Manoharan K,Maldonado-Perez D,Verrill C,Humphreys IR,Dong T

    更新日期:2020-10-30 00:00:00

  • Helminth-induced regulation of T-cell transfer colitis requires intact and regulated T cell Stat6 signaling in mice.

    abstract::Infection with parasitic worms (helminths) alters host immune responses and can inhibit pathogenic inflammation. Helminth infection promotes a strong Th2 and T regulatory response while suppressing Th1 and Th17 function. Th2 responses are largely dependent on transcriptional programs directed by Stat6-signaling. We ex...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.201848072

    authors: Metwali A,Winckler S,Urban JF Jr,Kaplan MH,Ince MN,Elliott DE

    更新日期:2020-10-16 00:00:00

  • Treatment and management of primary antibody deficiency: German interdisciplinary evidence-based consensus guideline.

    abstract::This evidence-based clinical guideline provides consensus-recommendations for the treatment and care of patients with primary antibody deficiencies (PADs). The guideline group comprised 20 clinical and scientific expert associations of the German, Swiss, and Austrian healthcare system and representatives of patients. ...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.202048713

    authors: Hanitsch L,Baumann U,Boztug K,Burkhard-Meier U,Fasshauer M,Habermehl P,Hauck F,Klock G,Liese J,Meyer O,Müller R,Pachlopnik-Schmid J,Pfeiffer-Kascha D,Warnatz K,Wehr C,Wittke K,Niehues T,von Bernuth H

    更新日期:2020-10-01 00:00:00

  • De novo polyamine synthesis supports metabolic and functional responses in activated murine NK cells.

    abstract::Cellular metabolism is dynamically regulated in NK cells and strongly influences their responses. Metabolic dysfunction is linked to defective NK cell responses in diseases such as obesity and cancer. The transcription factors, sterol regulatory element binding protein (SREBP) and cMyc, are crucial for controlling NK ...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.202048784

    authors: O'Brien KL,Assmann N,O'Connor E,Keane C,Walls J,Choi C,Oefner PJ,Gardiner CM,Dettmer K,Finlay DK

    更新日期:2020-09-18 00:00:00

  • Pharmacological inhibition of RORC2 enhances human Th17-Treg stability and function.

    abstract::Inflammatory bowel diseases (IBD) are chronic conditions that result from uncontrolled intestinal inflammation. Pathogenic Th17 cells, characterized by production of IL-17A in the absence of IL-10, are thought to contribute to this inflammation, but in humans, antibody-mediated blockade of IL-17A is an ineffective IBD...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.201948435

    authors: Boardman DA,Garcia RV,Ivison SM,Bressler B,Dhar TM,Zhao Q,Levings MK

    更新日期:2020-09-01 00:00:00

  • LIPS method for the detection of SARS-CoV-2 antibodies to spike and nucleocapsid proteins.

    abstract::Profiling antibodies to SARS-CoV-2 can help to assess potential immune response after COVID-19 disease. Luciferase IP system (LIPS) assay is a sensitive method for quantitative detection of antibodies to antigens in their native conformation. We here describe LIPS to detect antibody responses to SARS-CoV-2 spike (S) a...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.202048715

    authors: Haljasmägi L,Remm A,Rumm AP,Krassohhina E,Sein H,Tamm A,Kisand K,Peterson P

    更新日期:2020-08-01 00:00:00

  • Evidence for an involvement of the ubiquitin-like modifier ISG15 in MHC class I antigen presentation.

    abstract::The IFN stimulated gene 15 (ISG15) encodes a 15-kDa ubiquitin-like protein, that is induced by type I IFNs and is conjugated to the bulk of newly synthesized polypeptides at the ribosome. ISG15 functions as an antiviral molecule possibly by being covalently conjugated to viral proteins and disturbing virus particle as...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.202048646

    authors: Held T,Basler M,Knobeloch KP,Groettrup M

    更新日期:2020-07-20 00:00:00

  • IL-31 transgenic mice show reduced allergen-induced lung inflammation.

    abstract::Interleukin-31 (IL-31) is a Th2 cell-derived cytokine that has been closely linked to pruritic skin inflammation. More recently, enhanced IL-31 serum levels have also been observed in patients with allergic rhinitis and allergic asthma. Therefore, the main aim of this study was to unravel the contribution of IL-31 to ...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.202048547

    authors: Neuper T,Neureiter D,Sarajlic M,Strandt H,Bauer R,Schwarz H,Suchanek P,Korotchenko E,Dillon SR,Hammerl P,Stoecklinger A,Weiss R,Horejs-Hoeck J

    更新日期:2020-07-10 00:00:00

  • Tumor necrosis factor receptor family costimulation increases regulatory T-cell activation and function via NF-κB.

    abstract::Several drugs targeting members of the TNF superfamily or TNF receptor superfamily (TNFRSF) are widely used in medicine or are currently being tested in therapeutic trials. However, their mechanism of action remains poorly understood. Here, we explored the effects of TNFRSF co-stimulation on murine Foxp3+ regulatory T...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.201948393

    authors: Lubrano di Ricco M,Ronin E,Collares D,Divoux J,Grégoire S,Wajant H,Gomes T,Grinberg-Bleyer Y,Baud V,Marodon G,Salomon BL

    更新日期:2020-07-01 00:00:00

  • Mutations of the gene FNIP1 associated with a syndromic autosomal recessive immunodeficiency with cardiomyopathy and pre-excitation syndrome.

    abstract::AMPK (adenosine monophosphate-activated protein kinase) is phosphorylated (AMPK-P) in response to low energy through allosteric activation by Adenosine mono- or diphosphate (AMP/ADP). Folliculin (FLCN) and the FLCN-interacting proteins 1 and 2 (FNIP1, 2) modulate AMPK. FNIP1 deficiency patients have a AMPK-P gain of f...

    journal_title:European journal of immunology

    pub_type: 信件

    doi:10.1002/eji.201948504

    authors: Niehues T,Özgür TT,Bickes M,Waldmann R,Schöning J,Bräsen J,Hagel C,Ballmaier M,Klusmann JH,Niedermayer A,Pannicke U,Enders A,Dückers G,Siepermann K,Hempel J,Schwarz K,Viemann D

    更新日期:2020-07-01 00:00:00

  • Hhex regulates murine lymphoid progenitor survival independently of Stat5 and Cdkn2a.

    abstract::The transcription factor Hhex (hematopoietically expressed homeobox gene) is critical for development of multiple lymphoid lineages beyond the common lymphoid progenitor. In addition, Hhex regulates hematopoietic stem cell (HSC) self-renewal, emergency hematopoiesis, and acute myeloid leukemia initiation and maintenan...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.201948371

    authors: Jackson JT,O'Donnell K,Light A,Goh W,Huntington ND,Tarlinton DM,McCormack MP

    更新日期:2020-07-01 00:00:00

  • Beware of whom you live with: Your intestinal IgA may depend on it.

    abstract::In the past 15 years, it became clear that the symbiotic microbiota has an important impact on the development and regulation of the immune system. Consequently, it is incorrect to interpret a phenotype solely as a direct result of the genotype, without considering the impact of the microbiota. In fact, ignorance of t...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.202048615

    authors: Eberl G,Vieira P

    更新日期:2020-06-01 00:00:00

  • Harnessing proteases for T regulatory cell immunotherapy.

    abstract::The immune system is tightly regulated by a subset of T cells defined as regulatory T cells (Tregs). Tregs maintain immune homeostasis by restraining unwarranted immune cell activation and effector function. Here, we discuss an important but underappreciated role of proteases in controlling Treg function. Proteases re...

    journal_title:European journal of immunology

    pub_type: 杂志文章,评审

    doi:10.1002/eji.201948270

    authors: Amarnath S,Brown ML

    更新日期:2020-06-01 00:00:00

  • Specific microbiota enhances intestinal IgA levels by inducing TGF-β in T follicular helper cells of Peyer's patches in mice.

    abstract::In humans and mice, mucosal immune responses are dominated by IgA antibodies and the cytokine TGF-β, suppressing unwanted immune reactions but also targeting Ig class switching to IgA. It had been suggested that eosinophils promote the generation and maintenance of mucosal IgA-expressing plasma cells. Here, we demonst...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.201948474

    authors: Beller A,Kruglov A,Durek P,von Goetze V,Werner K,Heinz GA,Ninnemann J,Lehmann K,Maier R,Hoffmann U,Riedel R,Heiking K,Zimmermann J,Siegmund B,Mashreghi MF,Radbruch A,Chang HD

    更新日期:2020-06-01 00:00:00

  • CMTM7 plays key roles in TLR-induced plasma cell differentiation and p38 activation in murine B-1 B cells.

    abstract::Terminal differentiation of B cells into antibody-secreting cells is the foundation of humoral immune response. B-1 cells, which are different from B-2 cells, preferentially differentiate into plasma cells. CMTM7 is a MARVEL-domain-containing membrane protein predominantly expressed in B cells that plays an important ...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.201948363

    authors: Liu Z,Liu Y,Li T,Wang P,Mo X,Lv P,Ma D,Han W

    更新日期:2020-06-01 00:00:00

  • Soluble pattern recognition molecules: Guardians and regulators of homeostasis at airway mucosal surfaces.

    abstract::Maintenance of homeostasis at body barriers that are constantly challenged by microbes, toxins and potentially bioactive (macro)molecules requires complex, highly orchestrated mechanisms of protection. Recent discoveries in respiratory research have shed light on the unprecedented role of airway epithelial cells (AEC)...

    journal_title:European journal of immunology

    pub_type: 杂志文章,评审

    doi:10.1002/eji.201847811

    authors: Smole U,Kratzer B,Pickl WF

    更新日期:2020-05-01 00:00:00

  • CD5 blockade enhances ex vivo CD8+ T cell activation and tumour cell cytotoxicity.

    abstract::CD5 is expressed on T cells and a subset of B cells (B1a). It can attenuate TCR signalling and impair CTL activation and is a therapeutic targetable tumour antigen expressed on leukemic T and B cells. However, the potential therapeutic effect of functionally blocking CD5 to increase T cell anti-tumour activity against...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.201948309

    authors: Alotaibi F,Rytelewski M,Figueredo R,Zareardalan R,Zhang M,Ferguson PJ,Maleki Vareki S,Najajreh Y,El-Hajjar M,Zheng X,Min WP,Koropatnick J

    更新日期:2020-05-01 00:00:00

  • The multifaceted Foxp3fgfp allele enhances spontaneous and therapeutic immune surveillance of cancer in mice.

    abstract::It is well established that therapeutic impairment of Foxp3+ Treg in mice and humans favors immune rejection of solid tumors. Less explored is the impact Foxp3 allelic variants may have on tumor incidence, progression and therapy. In this work, we tested and demonstrate that the Foxp3fgfp reporter allele, found previo...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.201948251

    authors: Almeida-Santos J,Bergman ML,Amendoeira Cabral I,Correia V,Caramalho Í,Demengeot J

    更新日期:2020-03-01 00:00:00

  • Extracellular ADP augments microglial inflammasome and NF-κB activation via the P2Y12 receptor.

    abstract::The NLRP3 inflammasome is a molecular complex that translates signals from pathogens and tissue damage into inflammatory responses, and plays crucial roles in numerous neurological diseases. Activation of the NLRP3 inflammasome leads to caspase-1 dependent cleavage of pro-IL-1β to form mature IL-1β. By acting on the P...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.201848013

    authors: Suzuki T,Kohyama K,Moriyama K,Ozaki M,Hasegawa S,Ueno T,Saitoe M,Morio T,Hayashi M,Sakuma H

    更新日期:2020-02-01 00:00:00

  • All the small things: How virus-like particles and liposomes modulate allergic immune responses.

    abstract::Recent years have seen a dramatic increase in the range of applications of virus-like nanoparticle (VNP)- and liposome-based antigen delivery systems for the treatment of allergies. These platforms rely on a growing number of inert virus-backbones or distinct lipid formulations and intend to engage the host's innate a...

    journal_title:European journal of immunology

    pub_type: 杂志文章,评审

    doi:10.1002/eji.201847810

    authors: Kratzer B,Hofer S,Zabel M,Pickl WF

    更新日期:2020-01-01 00:00:00

  • A TRAV26-1-encoded recognition motif focuses the biased T cell response in celiac disease.

    abstract::The semi-public T-cell response towards the gluten epitope DQ2.5-glia-α2 uses a prototypic TCR encoded by the germline segments TRAV26-1 and TRBV7-2. Through mutagenesis experiments, we show that a TRAV26-1encoded recognition motif contacts the MHC β-chain and the TCR CDR3β loop underpinning this conserved T-cell resp...

    journal_title:European journal of immunology

    pub_type: 信件

    doi:10.1002/eji.201948235

    authors: Frick R,Gunnarsen KS,Dahal-Koirala S,Risnes LF,Sollid LM,Sandlie I,Høydahl LS,Løset GÅ

    更新日期:2020-01-01 00:00:00

  • Increased ILC3s associated with higher levels of IL-1β aggravates inflammatory arthritis in mice lacking phagocytic NADPH oxidase.

    abstract::The role of redox regulation in immune-mediated arthritis has been previously described. However, the relationship between innate immune cells, including innate lymphoid cells (ILCs) and phagocyte-derived ROS, in this process remains unclear. Here, we characterize ILCs and measure the IL-1 family cytokines along with ...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.201948141

    authors: Chan TY,Yen CL,Huang YF,Lo PC,Nigrovic PA,Cheng CY,Wang WZ,Wu SY,Shieh CC

    更新日期:2019-11-01 00:00:00

  • Bromodomain inhibitor I-BET151 suppresses immune responses during fungal-immune interaction.

    abstract::Changes in the epigenetic landscape of immune cells are a crucial component of gene activation during the induction of inflammatory responses, therefore it has been hypothesized that epigenetic modulation could be employed to restore homeostasis in inflammatory scenarios. Fungal pathogens cause a large burden of morbi...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.201848081

    authors: Domínguez-Andrés J,Ferreira AV,Jansen T,Smithers N,Prinjha RK,Furze RC,Netea MG

    更新日期:2019-11-01 00:00:00

  • SIRPα+ dendritic cells promote the development of fibroblastic reticular cells in murine peripheral lymph nodes.

    abstract::Nonhematopoietic stromal cells contribute to the organization and homeostasis of secondary lymphoid organs by producing cytokines and chemokines. The development and maintenance of these stromal cells are thought to be regulated by innate immune cells. Indeed, we recently showed that signal regulatory protein α (SIRPα...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.201948103

    authors: Komori S,Saito Y,Respatika D,Nishimura T,Kotani T,Murata Y,Matozaki T

    更新日期:2019-09-01 00:00:00

  • Single-cell transcriptomes of murine bone marrow stromal cells reveal niche-associated heterogeneity.

    abstract::Bone marrow (BM) stromal cells are important in the development and maintenance of cells of the immune system. Using single cell RNA sequencing, we here explore the functional and phenotypic heterogeneity of individual transcriptomes of 1167 murine BM mesenchymal stromal cells. These cells exhibit a tremendous heterog...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.201848053

    authors: Addo RK,Heinrich F,Heinz GA,Schulz D,Sercan-Alp Ö,Lehmann K,Tran CL,Bardua M,Matz M,Löhning M,Hauser AE,Kruglov A,Chang HD,Durek P,Radbruch A,Mashreghi MF

    更新日期:2019-09-01 00:00:00

  • T-cell-derived cytokines enhance the antigen-presenting capacity of human neutrophils.

    abstract::Activated allergen-specific Th2 and Th1 cells release cytokines that transform neutrophils into functional APCs characterized by the expression of HLA-DR and CD58 as well as enhanced survival and antigen uptake, irrespectively of the presence of IL-10, which reduces allergen uptake by neutrophils. ...

    journal_title:European journal of immunology

    pub_type: 信件

    doi:10.1002/eji.201848057

    authors: Samadi N,Polak D,Kitzmüller C,Steinberger P,Zlabinger GJ,Jahn-Schmid B,Bohle B

    更新日期:2019-09-01 00:00:00

  • Targeting the tumor microenvironment and T cell metabolism for effective cancer immunotherapy.

    abstract::The successful implementation of immunotherapies has provided new impetus in the fight against cancer. Antibody-mediated blockade of immune checkpoint molecules PD-1/PD-L1 and CTLA-4 has had a dramatic impact upon the treatment of previously intractable cancers such as malignant melanoma, while adoptive cell therapies...

    journal_title:European journal of immunology

    pub_type: 杂志文章,评审

    doi:10.1002/eji.201848058

    authors: Hope HC,Salmond RJ

    更新日期:2019-08-01 00:00:00

  • Semaphorin 7A modulates cytokine-induced memory-like responses by human natural killer cells.

    abstract::Cytokine-induced memory-like (CIML) NK cells are endowed with the capacity to mediate enhanced effector functions upon cytokine or activating receptor restimulation for several weeks following short-term preactivation with IL-12, IL-15, and IL-18. Promising results from a first-in-human clinical trial highlighted the ...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.201847931

    authors: Ghofrani J,Lucar O,Dugan H,Reeves RK,Jost S

    更新日期:2019-08-01 00:00:00

  • Naturally processed HLA-DR3-restricted HHV-6B peptides are recognized broadly with polyfunctional and cytotoxic CD4 T-cell responses.

    abstract::Human herpes virus 6B (HHV-6B) is a widespread virus that infects most people early in infancy and establishes a chronic life-long infection with periodic reactivation. CD4 T cells have been implicated in control of HHV-6B, but antigenic targets and functional characteristics of the CD4 T-cell response are poorly unde...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.201948126

    authors: Becerra-Artiles A,Cruz J,Leszyk JD,Sidney J,Sette A,Shaffer SA,Stern LJ

    更新日期:2019-08-01 00:00:00

  • Brucella abortus nitric oxide metabolite regulates inflammasome activation and IL-1β secretion in murine macrophages.

    abstract::NLRP3 inflammasome is a protein complex crucial to caspase-1 activation and IL-1β and IL-18 maturation. This receptor participates in innate immune responses to different pathogens, including the bacteria of genus Brucella. Our group recently demonstrated that Brucella abortus-induced IL-1β secretion involves NLRP3 in...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.201848016

    authors: Campos PC,Gomes MTR,Marinho FAV,Guimarães ES,de Moura Lodi Cruz MGF,Oliveira SC

    更新日期:2019-07-01 00:00:00

  • 'Beauty and the beast' in infection: How immune-endocrine interactions regulate systemic metabolism in the context of infection.

    abstract::The immune and endocrine systems ensure two vital functions in the body. The immune system protects us from lethal pathogens, whereas the endocrine system ensures proper metabolic function of peripheral organs by regulating systemic homeostasis. These two systems were long thought to operate independently. The immune ...

    journal_title:European journal of immunology

    pub_type: 杂志文章,评审

    doi:10.1002/eji.201847895

    authors: Wensveen FM,Šestan M,Turk Wensveen T,Polić B

    更新日期:2019-07-01 00:00:00

  • The B cell novel protein 1 (BCNP1) regulates BCR signaling and B cell apoptosis.

    abstract::The BCR plays a central role in B cell development, survival, activation, and differentiation. We have identified the B cell novel protein 1 (BCNP1) as a new regulator of BCR signaling. BCNP1 contains a pleckstrin homology domain, three proline-rich motifs, and a potential SH2 binding site, and is predominantly expres...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.201847985

    authors: Hong R,Lai N,Ouchida R,Xiong E,Zhou Y,Min Q,Liu J,Tang Y,Hikida M,Tsubata T,Wang Y,Wang JY

    更新日期:2019-06-01 00:00:00

  • The thioredoxin-1 and glutathione/glutaredoxin-1 systems redundantly fuel murine B-cell development and responses.

    abstract::Antioxidant systems maintain cellular redox homeostasis. The thioredoxin-1 (Trx1) and the glutathione (GSH)/glutaredoxin-1 (Grx1) systems are key players in preserving cytosolic redox balance. In fact, T lymphocytes critically rely on reducing equivalents from the Trx1 system for DNA biosynthesis during metabolic repr...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.201848044

    authors: Muri J,Thut H,Heer S,Krueger CC,Bornkamm GW,Bachmann MF,Kopf M

    更新日期:2019-05-01 00:00:00

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