解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:OBJECTIVES:The objective of this study was to evaluate racial differences in cancer treatment and survival in gastroenteropancreatic neuroendocrine tumor (GEP-NET) patients. METHODS:Using the Surveillance, Epidemiology, and End Results Registry, we identified patients with GEP-NETs of the stomach, small intestine (SI)...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001707
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:We conducted this study to ascertain whether chronic inflammation secondary to chronic pancreatitis (CP) has any association with myocardial infarction(MI). METHODS:Data were collected from a commercial database (Explorys, Inc, IBM Watson, Ohio). Adults with the diagnosis of "chronic pancreatitis," based on ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001721
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVES:Acute pancreatitis (AP) guidelines for adult patients do not recommend routine prophylactic use of antibiotics because of no clinical merit on mortality, infectious complications, or length of stay. Although the mortality of pediatric AP is low, no studies have explored the rationale for antibiotic use in pe...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001682
更新日期:2020-11-01 00:00:00
abstract::Pancreatic cystic insulinoma is an uncommon tumor. Perioperative localization remained challenging if the tumor is atypical with cystic feature or in small size. Near-infrared (NIR) imaging is a technique by injecting fluorescent dye intravenously, which accumulates to the target lesion and creating signal by laser so...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001678
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVES:The use of thermal ablative therapies in the pancreatic tumors is limited because of the risk of the vessel injury and potential pancreatitis or fistula formation. Electrochemotherapy (ECT) is an ablative therapy with an established role in the treatment of cutaneous and liver tumors. This study was designed...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001642
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVES:Neoadjuvant chemotherapy (NAC) has improved overall survival in patients with pancreatic ductal adenocarcinoma (PDAC), but its effects on immune gene signatures are unknown. Here, we examined the immune transcriptome after NAC for PDAC. METHODS:Resected tumor specimens were obtained from 140 patients with P...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001665
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVES:To determine if RNA collected from pancreatic tissue, without the use of RNAlater, is useful for RNA sequencing (RNA-seq) despite degradation, and if so, then, via RNA-seq analysis, how does gene expression vary between pancreatitis etiologies. METHODS:Data were assessed in 2 dimensions, based on RNA-seq si...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001607
更新日期:2020-09-01 00:00:00
abstract::The surgical treatment of pancreatic cancer (PDAC) has seen sweeping changes during the past 5 decades. Up to the middle of the 20th century resection rates were below 5%, but the numbers of curative resections for PDAC are now continuously increasing due to improved neoadjuvant treatment concepts as well as progress ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001634
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVES:Single-institution studies have shown improved outcomes among patients with a pathologic complete response (pCR) following neoadjuvant therapy. We sought to evaluate the impact of pCR and near-complete response (nCR) on overall survival (OS) using a large national database. METHODS:The National Cancer Datab...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001590
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis involves persistent serum amylase levels of 3 times or more the standard upper limit. However, these criteria were mostly based on retrospective studies and not necessarily supported by diagnostic imaging. Our prospective study aimed to i...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001606
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVES:This analysis investigated nomogram use to evaluate metastatic pancreatic cancer prognosis. METHODS:Thirty-four baseline factors were examined in the Metastatic Pancreatic Adenocarcinoma Clinical Trial (MPACT) (nab-paclitaxel plus gemcitabine vs gemcitabine) data set. Factors significantly (P < 0.1) associa...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001563
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVES:Existing reference ranges for stool fat and energy absorption were developed using subjects in controlled environments on precise diets. This study measured energy and fat absorption in healthy, community-dwelling adults eating a moderate-to-high fat American diet via stool- and serum-based methods. METHODS...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001587
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVES:Tumor necrosis is often found in pancreatic ductal adenocarcinoma (PDAC). Objective histological assessment and adequate radiological detection of necrosis could be used as biomarkers for therapeutic decision. However, standardized clinical utility of necrosis remains unknown. Here, we aimed to determine the...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001539
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVES:Previously, we showed that diazoxide (DZ), an effective ischemic preconditioning agent, protected rodent pancreas against ischemia-reperfusion injury. Here, we further investigate whether DZ supplementation to University of Wisconsin (UW) solution during pancreas procurement and islet isolation has similar c...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001557
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVES:We aimed to determine the difference in endoscopic ultrasonography (EUS) images between portal vein (PV) and arterial invasion of pancreatic cancer and to develop criteria for arterial involvement. METHODS:We reviewed EUS data of consecutive patients who underwent distal pancreatectomy from December 2010 to...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001523
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVES:We evaluated carcinoid syndrome (CS) symptoms and the real-world effectiveness of telotristat ethyl (TE) among patients with ≤3 bowel movements (BM) per day. METHODS:Patients with CS initiating TE between March and November 2017 could participate in a nurse support program collecting demographic and CS symp...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001496
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVES:Hypertriglyceridemia-induced pancreatitis is an important cause of acute pancreatitis (AP) in children, which lacks established guidelines. The aim of this study was to review management approaches at a single pediatric center. METHODS:This retrospective study included all inpatients younger than 21 years w...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001505
更新日期:2020-03-01 00:00:00
abstract::The 3 International Conference for Cancer Metabolism and Therapy was successfully held at the South Hospital Conference Center of Shanghai First People's Hospital, nearly 200 international experts from the field of cancer metabolism and therapy and about two thousand local scientists attended the conference. The confe...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001482
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:Given the lack of consensus on surveillance guidelines after pancreatic neuroendocrine tumor (PanNET) resection, we assessed outcomes in a large cohort of patients with nonmetastatic, surgically resected PanNETs. METHODS:Data of patients with PanNETs resected between 1990 and 2017 were retrospectively collec...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001477
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVES:The aim was to determine whether serum levels of carbohydrate antigen (CA) 19-9, interleukin 6 (IL-6), and YKL-40 could identify advanced disease and poor prognosis in pancreatic cancer (PC) patients intraoperatively diagnosed with locally advanced or metastatic disease. METHODS:Two hundred ninety patients ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001466
更新日期:2020-01-01 00:00:00
abstract::Metastatic pancreatic cancer (PC) is an aggressive malignancy, with most patients deriving benefit only from first-line chemotherapy. Increasingly, the recommended treatment for those with a germline mutation in a gene involved in homologous recombination repair is with a platinum drug followed by a poly (ADP-ribose) ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001461
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:We evaluated how well phase II trials in locally advanced and metastatic pancreatic cancer (LAMPC) meet current recommendations for trial design. METHODS:We conducted a systematic review of phase II first-line treatment trial for LAMPC. We assessed baseline characteristics, type of comparison, and primary e...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001429
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to report the prevalence and predictors of abdominal pain and disability 1 year after an acute pancreatitis (AP) attack. METHODS:Patients were prospectively enrolled between December 2012 and April 2016. Enrolled subjects were contacted at a median of 13 months after enrollment. Mult...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001434
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVE:Pancreatic ductal adenocarcinoma (PDAC) is the third most common cause of cancer death in the United States. Improved characterized models of PDAC are needed for drug screening. METHODS:We grew 4 established pancreatic cancer cell lines in hanging drop cultures to produce spheroids. We also grew organoids fr...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001390
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVES:A selective therapy for pancreatitis is total pancreatectomy and islet autotransplantation. Outcomes and geographical variability of patients who had total pancreatectomy (TP) alone or total pancreatectomy with islet autotransplantation (TPIAT) were assessed. METHODS:Data were obtained from the Healthcare C...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001405
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVES:In patients with acute recurrent pancreatitis (ARP), pancreas divisum, and no other etiologic factors, endoscopic retrograde cholangiopancreatography (ERCP) with minor papilla endoscopic sphincterotomy (miES) is often performed to enlarge the minor papillary orifice, based on limited data. The aims of this s...
journal_title:Pancreas
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/MPA.0000000000001370
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:In a continuation of previous work, Reg3γ protein was further evaluated as a biomarker of pancreatic injury using immunohistochemistry in an additional species. METHODS:Mice and rats were treated with intraperitoneal cerulein injections, creating acute pancreatic injury. Mice received 2, 4, or 6 doses, and r...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001382
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:Ethnic disparities in pancreatic cancer (PanCan) incidence exist, but little is known about incidence trends in heterogeneous Asian Americans. We examined PanCan incidence and temporal patterns among detailed ethnic populations, including Asian American subgroups. METHODS:A total of 71,099 invasive exocrine ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001337
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVES:Understanding the effect of lymph node metastasis (LNM) on prognosis in pancreatic neuroendocrine neoplasm is helpful for surgery and follow-up. In this study, we investigated the significance of LNM in well-differentiated pancreatic neuroendocrine tumors (PanNETs) according to the World Health Organization ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001355
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVES:We compared the clinical profiles and organ manifestations of the commonly encountered immunoglobulin G4-related diseases (IgG4-RDs) on either side of the diaphragm: head and neck (HN) versus pancreatobiliary (PB) in IgG4-RD. METHODS:From the Mayo Clinic, Rochester, database, we identified 53 HN and 88 PB I...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001332
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVES:Mammalian targets of rapamycin inhibitors (mTORi) are considered second-line immunosuppression agents because of associated increases in rejection and impaired wound healing. Recent reports indicate mTORi have been linked to improved survival, decreased inflammatory response in pancreatitis, and antiprolifer...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001322
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:Chronic pancreatitis is the consequence of multiple episodes of recurrent acute pancreatitis (RAP). We hypothesized that apigenin can minimize the sequelae of RAP by limiting acinar cells' proinflammatory signaling pathways. METHODS:AR42J acinar cells were treated in vitro with transforming growth factor β (...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001310
更新日期:2019-05-01 00:00:00
abstract::This review critically analyzes how machine learning is being used to support clinical decision-making in the management of potentially resectable pancreatic cancer. Following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) guidelines, electronic searches of MEDLINE, Embase, PubMed, and Coc...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001312
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVES:Chronic asymptomatic pancreatic hyperenzymemia (CAPH) was described as a benign disease. However, we already described clinically relevant findings requiring surgery or follow-up in half of the subjects. The aim of this study was to evaluate the long-term outcome of CAPH in terms of symptoms and evolution to...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001272
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVES:Acute pancreatitis (AP) is a leading cause of hospitalization for a gastrointestinal illness in the United States. We hypothesized that enhanced recovery approaches may lead to earlier time to refeeding in patients with AP. METHODS:We performed a double-blind, randomized controlled trial of patients admitte...
journal_title:Pancreas
pub_type: 杂志文章,随机对照试验
doi:10.1097/MPA.0000000000001225
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVES:Angiogenesis plays a major role in tumor progression and metastasis; however, its role in pancreatic cancer (PC) remains unclear. The aim of the study was to explore the cumulative evidence concerning the impact of microvessel density (MVD), an estimator of angiogenesis, on resected PC patients. METHODS:A s...
journal_title:Pancreas
pub_type: 杂志文章,meta分析
doi:10.1097/MPA.0000000000001237
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess the relationship between the computed tomography (CT) pancreatic parenchyma attenuation value and clinically relevant postoperative pancreatic fistula (POPF). METHODS:The medical records of 115 patients who underwent pancreaticoduodenectomy and preoperative dynamic CT were...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001229
更新日期:2019-02-01 00:00:00
abstract::The last 5 years have seen a dramatic increased interest in the field of exosome biology. Although much is unknown about the role of exosomes in human health and disease, disparate scientific disciplines are recognizing the highly conserved role that exosomes play in fundamental biological processes. Recently, there h...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/MPA.0000000000001203
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:Many patients with recurrent acute and chronic pancreatitis who are candidates for total pancreatectomy and islet cell autotransplantation (TPIAT) undergo endoscopic retrograde cholangiopancreatography (ERCP). However, little is known on the impact of ERCP on TPIAT outcomes. We aimed to explore the effect of...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001188
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:Rare cases of pancreatic neuroendocrine tumors (PNETs) that produce only proinsulin (PI) and manifest with hypoglycemia have been reported. Proinsulin expression in PNET has not been systematically studied, and the clinicopathologic features of such tumors remain unknown. METHODS:We studied expression of PI...
journal_title:Pancreas
pub_type: 杂志文章,多中心研究
doi:10.1097/MPA.0000000000001196
更新日期:2019-01-01 00:00:00