Abstract:
OBJECTIVE:We conducted this study to ascertain whether chronic inflammation secondary to chronic pancreatitis (CP) has any association with myocardial infarction(MI). METHODS:Data were collected from a commercial database (Explorys, Inc, IBM Watson, Ohio). Adults with the diagnosis of "chronic pancreatitis," based on Systematized Nomenclature of Medicine-Clinical Terms, were included in the CP group, and the rest of the patients were included in the non-CP group. The prevalence of MI was compared in both groups, and statistical multivariate model was performed. RESULTS:A total of 28,842,210 patients were included in the study. The overall prevalence of MI was 14.22% in the CP group as compared with 3.23% in the non-CP group (P < 0.0001). In the multivariate analysis, the odds ratio (OR) for MI in CP group was 1.453 (95% confidence interval, 1.418-1.488, P < 0.0001). Hypertension was a strong predictor for MI in the CP group with an OR of 3.2 (95% confidence interval, 3.0-3.5), followed by chronic kidney disease, older than 65 years, dyslipidemia, diabetes mellitus, obesity, alcohol abuse, smoking, White race, and male sex. CONCLUSIONS:This study showed that CP is associated with comorbidities, which can increase the prevalence and OR of MI.
journal_name
Pancreasjournal_title
Pancreasauthors
Khan D,Abureesh M,Alkhayyat M,Sadiq W,Alshami M,Munir AB,Karam B,Deeb L,Lafferty Jdoi
10.1097/MPA.0000000000001721subject
Has Abstractpub_date
2021-01-01 00:00:00pages
99-103issue
1eissn
0885-3177issn
1536-4828pii
00006676-202101000-00015journal_volume
50pub_type
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