Abstract:
OBJECTIVES:Recent observations demonstrated the expression of the insulin receptor (InsR) and its functional interaction with the transient receptor potential vanilloid type 1 receptor (TRPV1) in sensory ganglion neurons. Because sensory nerves are implicated in pancreatic inflammatory processes, we studied the colocalization of the InsR with TRPV1 and proinflammatory neuropeptides in spinal and vagal pancreatic afferent neurons. METHODS:Immunohistochemistry and quantitative morphometry were used to analyze the expression of TRPV1, InsR, substance P (SP), and calcitonin gene-related peptide (CGRP) in retrogradely labeled pancreatic dorsal root ganglion (DRG) and nodose ganglion (NG) neurons. RESULTS:The proportions of retrogradely labeled pancreatic TRPV1-, InsR-, SP-, and CGRP-immunoreactive neurons amounted to 68%, 48%, 33%, and 54% in DRGs and 64%, 49%, 40%, and 25% in the NGs. Of the labeled DRG and NG neurons, 23% and 35% showed both TRPV1 and InsR immunoreactivity. Colocalization of the InsR with SP or CGRP was demonstrated in 14% and 28% of pancreatic DRG and 24% and 8% of pancreatic NG neurons. CONCLUSIONS:The present findings provide morphological basis for possible functional interactions among the nociceptive ion channel TRPV1, the InsR, and the proinflammatory neuropeptides SP and CGRP expressed by pancreatic DRG and NG neurons.
journal_name
Pancreasjournal_title
Pancreasauthors
Lázár BA,Jancsó G,Oszlács O,Nagy I,Sántha Pdoi
10.1097/MPA.0000000000000959subject
Has Abstractpub_date
2018-01-01 00:00:00pages
110-115issue
1eissn
0885-3177issn
1536-4828journal_volume
47pub_type
杂志文章相关文献
PANCREAS文献大全abstract:OBJECTIVES:Pancreatic anastomotic leakage remains a major troublesome complication after pancreaticoduodenectomy. Thus, various technical modifications regarding the pancreatic anastomosis after pancreaticoduodenectomy have been attempted to minimize anastomotic leakage. We have performed duct-to-mucosa pancreaticojeju...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3180676dc2
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVES:Despite decades of effort, the 5-year overall survival rate of pancreatic cancer (PC) remains at only approximately 5%. Until now, no detailed knowledge regarding the worldwide research architecture of PC has yet been established. METHODS:Hence, we conducted this scientometric analysis to quantify the globa...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000693
更新日期:2016-11-01 00:00:00
abstract::Genistein is a plant isoflavonoid bearing potent tumor growth-regulating characteristics. This effect of genistein has been attributed partially to its tyrosine kinase-regulating properties, resulting in cell-cycle arrest and limited angiogenesis. Genistein has been used in chemotherapy-resistant cases of advanced leu...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200101000-00001
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVES:Rare cases of pancreatic neuroendocrine tumors (PNETs) that produce only proinsulin (PI) and manifest with hypoglycemia have been reported. Proinsulin expression in PNET has not been systematically studied, and the clinicopathologic features of such tumors remain unknown. METHODS:We studied expression of PI...
journal_title:Pancreas
pub_type: 杂志文章,多中心研究
doi:10.1097/MPA.0000000000001196
更新日期:2019-01-01 00:00:00
abstract:UNLABELLED:Serum adiponectin (ADP) levels are reported inversely related to the risk in breast, endometrial cancer, and gastric cancer. Serum ADP as a potential marker compared with CA-19-9 in pancreatic carcinoma (PC) and chronic pancreatitis (CP) was studied. Adiponectin and CA-19-9 levels were examined at the time o...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3180547709
更新日期:2007-07-01 00:00:00
abstract::We demonstrated dynamic aspects of granulocyte activation in rat severe acute pancreatitis, which was induced by cerulein and aggravated following lipopolysaccharide (LPS) injection. Pancreatitis induced by cerulein increased intracellular elastase activity of granulocytes in the blood. However, significant systemic c...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200308000-00004
更新日期:2003-08-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess the relationship between the computed tomography (CT) pancreatic parenchyma attenuation value and clinically relevant postoperative pancreatic fistula (POPF). METHODS:The medical records of 115 patients who underwent pancreaticoduodenectomy and preoperative dynamic CT were...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001229
更新日期:2019-02-01 00:00:00
abstract::Islet amyloid polypeptide (IAPP) has been recently identified as the principal constituent of amyloid deposits in pancreatic islets of patients with type 2 (non-insulin-dependent) diabetes mellitus and causes insulin resistance in some target cells. In addition, glucose-induced insulin secretion is inhibited by IAPP. ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199207000-00009
更新日期:1992-01-01 00:00:00
abstract::Solid pseudopapillary tumor of the pancreas is a rare neoplasm with low malignant potential, which affects predominantly young females. Only approximately 10% to 15% cases of solid pseudopapillary tumors (SPTs) are malignant. We present the case of a 57-year-old woman who developed malignant SPT of the pancreas. Meanw...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/MPA.0b013e31824d52c7
更新日期:2012-11-01 00:00:00
abstract::A case of relapsing pancreatitis in a young man is presented. Stenosis of the main duct and cystic lesions of the tail of the pancreas were shown by ultrasonography, CT scan, and endoscopic retrograde cholangiopancreatography (ERCP). After a wrong diagnosis of cancer, the pathological examination demonstrated an eosin...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199001000-00016
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVE:Members of the transient receptor potential (TRP) channels are involved in mediating the electrical excitability and stimulus-secretion coupling in the pancreatic β-cells. The expression and the relative abundance of different TRP channels in the human β-cells are unknown. The objective of this study was to e...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000685
更新日期:2017-01-01 00:00:00
abstract::The clinical, diagnostic, and therapeutic aspects of 27 patients with pancreatopleural fistula (PPF) reported in the literature, and two additional patients managed by the authors, form the basis of this report. The diagnosis of PPF is based on the triad of massive pleural effusions, elevated pleural fluid amylase, an...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198605000-00013
更新日期:1986-01-01 00:00:00
abstract:INTRODUCTION:Hypercytokinemia is known to occur in severe acute pancreatitis, suggesting that the production, deposition, and degradation of the extracellular matrix (ECM) occur actively as a result of the actions of the complicated cytokine network. AIMS AND METHODOLOGY:To examine the influence of cytokines and growt...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200303000-00008
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVES:Clinical trials are a prerequisite for evidence-based medicine. Trial representativity by internal and external validities is an assumption for a transfer into the real world. METHODS:A questionnaire addressing several forms of bias was established. Randomized controlled trials for adjuvant treatment of pan...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31819d7370
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVES:Porcine islets are the most suitable for xeno-islet transplantation. However, it is necessary to establish an effective preservation method against its fragility. Recently, we developed a new cooling and preservation (Keep and Fresh [KFC]; FUJIYA Co, Tokushima, Japan) system, which can maintain viability of ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181dab19a
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVES:Endoscopic ultrasound (EUS) quality benchmarks for pancreatic disease previously focused on maintaining thresholds of diagnostic accuracy for fine-needle aspiration and measuring complications. We aimed to evaluate quality indicators when performing EUS specifically for the diagnosis of chronic pancreatitis ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3182a85e1e
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:Acute pancreatitis is associated with compromised pancreatic microcirculation. Galanin is a vasoactive neuropeptide, but its role in the regulation of pancreatic vascular perfusion (PVP) is unclear. METHODS:Localization of galanin immunoreactivity was investigated by immunohistochemistry, and the effects of...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31815ac561
更新日期:2008-04-01 00:00:00
abstract::The human exocrine pancreas consists of 2 main cell types: acinar and ductal cells. These exocrine cells interact closely to contribute to the secretion of pancreatic juice. The most important ion in terms of the pancreatic ductal secretion is HCO3. In fact, duct cells produce an alkaline fluid that may contain up to ...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/MPA.0000000000000421
更新日期:2015-11-01 00:00:00
abstract::Platelet-activating factor (PAF) may play a critical and primary role in the pathogenesis of acute pancreatitis and pancreatitis-associated distant organ injury. The present study evaluated the effect of a PAF antagonist, lexipafant (an (S)-4-methyl-2[methyl-imidazo[4,5-c]pyridin-1-ylmethyl)-benzene sulphonyl]-amino]p...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199808000-00001
更新日期:1998-08-01 00:00:00
abstract:OBJECTIVE:The transcription factor Stat1 is a member of the family of signal transducers and transcription activators and responds to interferon-γ stimulation. p21 is a p53-responsive gene for cell cycle regulation and mediates Stat1 antitumor activity. The aim of this study was to analyze their expression for predicti...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000074
更新日期:2014-05-01 00:00:00
abstract::The influence of the neuropeptide galanin, present in intrapancreatic nerve endings, on the endocrine pancreas is well known. The most potent effect of galanin is inhibition of insulin release. Little is known of its effect on the exocrine pancreas. Whether galanin plays a role in the regulation of exocrine pancreatic...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199211000-00001
更新日期:1992-01-01 00:00:00
abstract::Pretreatment of rat pancreatic acini with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) for 5 or 10 min reduced cytosolic free calcium and amylase secretion stimulated by submaximal concentration (10(-6) M) of carbachol in a dose-dependent manner. 10(-7) M TPA inhibited initial amylase secretion and had no effect on sus...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199101000-00015
更新日期:1991-01-01 00:00:00
abstract::Although previous reports suggest interactions between the endocrine and the exocrine pancreas, insulin's effect on pancreatic exocrine function remains unclear. Chronic pancreatic fistulae were created in five dogs; these animals were studied using the euglycemic, hyperinsulinemic clamp technique. After a 30-min unst...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199605000-00004
更新日期:1996-05-01 00:00:00
abstract::With a nitrosamine induced hamster pancreatic cancer cell line (HaP-T1), survival time and metastatic rates were compared between orthotopic cell implantation (OCI; n = 5) and orthotopic tissue implantation (OTI; n = 5) models. All the tumors were palpable (100% tumor take) after 1 week in both groups. Hamsters in the...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200003000-00007
更新日期:2000-03-01 00:00:00
abstract::Clinical and translational research is critical for the development of improvement in care of pancreatic diseases. Major concerns are the lack of dedicated trainees in pancreatic research and the difficulty for the remaining trainees to develop independent research careers to be included into the pancreas research com...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181c63422
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:Multiple organ failure because of systemic inflammatory response in the early phase and sepsis in the late phase is the main contributor to high mortality in severe acute pancreatitis (SAP). High-mobility group box chromosomal protein 1 (HMGB1) was recently identified as a potent proinflammatory mediator and ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000236741.15477.8b
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVES:Sex-determining region Y (SRY) box 9 (SOX9) is an important transcription factor required for development and has been implicated in several types of cancer. Sex-determining region Y box 9 has never been linked to pancreatic ductal adenocarcinoma (PDAC) and intraductal papillary mucinous neoplasm (IPMN) of t...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318269d281
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to assess the association of hemodynamic factors with 90-day mortality in critically ill patients with severe acute pancreatitis (SAP). METHODS:One hundred fifty-nine consecutive patients with SAP admitted to the intensive care units between January 2005 and December 2008 were incl...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318264c9f7
更新日期:2013-03-01 00:00:00
abstract::A 66-year-old patient had been admitted four times for recurrent episodes of acute pancreatitis. At each time, elevated serum calcium levels, between 13.5-14.5 mg/dl, were found. Surgical drainage of necrotic pancreatic tissue had to be done on one occasion. Extensive investigations failed to disclose any conventional...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198906000-00017
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVE:All forms of commonly practiced enteral feeding techniques stimulate pancreatic secretion, and only intravenous feeding avoids it. In this study, we explored the possibility of more distal enteral infusions of tube feeds to see whether activation of the ileal brake mechanism can result in enteral feeding with...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000183374.11919.e5
更新日期:2005-11-01 00:00:00